Adverse Outcome Pathway on binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain

Approaches, limitations and challenges in development of biomarker-based strategy for impact assessment of neuroactive compounds in the aquatic environment

“…The suggested AOs are increased/decreased depression and increased agitation for serotonin receptors, epileptic seizures for GABA receptors (AOP10; [75,76]) and impairment of learning and memory for glutamate receptors (AOP12; AOP13; AOP48; [74,77,78]). There are also available AOPs related to activation of cholinergic receptors [79], while dopamine receptors are completely neglected in AOP framework.…”