Adverse Physiological and Biochemical Effects of Synthetic Human Insulin in Diabetic Type-2 Patients, A Comparative Clinical Study

Abstract

Background: The use of Synthetic human insulin in diabetic individuals may develop number of serious medical complications in population like Hypoglycemia, Weight gain, Little Skin Depression and Dementia. Aims and Objectives: The aims and objects of current study were to provide awareness about the recent Biochemical and Physiological side effects of Artificial Insulin Therapy for Type 2 Diabetes Mellitus to the people. Study Design: A comparative clinical study. Place and Duration: Present study was conducted in Lahore Medical & Dental College Lahore, The university of Lahore, Lahore, Suleman Roshan medical college Tando Adam Sindh and Allama Iqbal Medical College Lahore Pakistan from March 2021 June 2022. Methodology: Total 450 diabetic type- 2 patients of age 40-60 years were selected for present study and they were divided into three different groups regarding injected units of synthetic insulin. In Group-A 100 male and 50 female were taking 20 units twice a day, whereas 100 male and 50 female individuals with diabetes type-2 of Group-B were injected 30 units twice a day while 80 male and 40 female of Group-C were taking 45 units twice a day respectively. Fasting and Random glucose levels, Body mass index (BMI), levels of Dementia and Skin Depression parameters of each individual were measured and compared group wise. Results: A remarkable significant changes (P≤0.05) in Fasting glucose levels, Random glucose levels after 2 hour of meal, Random glucose levels after 3 hour of meal, Random glucose levels after 4 hour of meal, Body mass index, body mass index after 6 month, body mass index after 12 month, Incidence of severe hypoglycemia of male and female were concluded in group-B and group-C as compared with group-A, because 20 units of insulin created less hypoglycemic effects as compared with 30 and 45 units which were injected in Group-B and Group-C comparatively. Practical implication: Awareness about side effects of artificial Insulin therapy for Type 2 Diabetes Mellitus to the people is so important and helpful for quality of life and safety. Conclusion: The findings of present study were indicated that long term insulin therapy develop hypoglycemia and significant changes (P≤0.05) in BMI in patients with diabetes type-2. It was concluded that a significant (P≤0.05) weight gain in regular user of synthetic insulin diabetic type-2 patients was very common. Keywords: Hypoglycemia, Synthetic insulin, Body mass index, Diabetes Mellitus