Adverse transfusion reactions and what we can do

Wang, Yajie; Rao, Quan; Li, Xiaofei

doi:10.1080/17474086.2022.2112564

Cited by 3 publications

(2 citation statements)

References 187 publications

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“…Differentiating between intravascular hemolysis caused by a major ABO mismatch transfusion and extravascular hemolysis induced by clinically significant alloantibody reactions is crucial. Notably, intravascular hemolysis presents with severe symptoms [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Pre-Transfusion Crossmatch Test Using Microscanner C3

Park,

Jang,

Lim

et al. 2024

Diagnostics

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A pre-transfusion crossmatch test is crucial for ensuring safe blood transfusions by identifying the compatibility between donor and recipient blood samples. Conventional tube methods for crossmatching have limitations, including subjectivity in result interpretation and the potential for human error. In this study, we evaluated the diagnostic performance of a new crossmatch test using Microscanner C3, which can overcome these shortcomings. The crossmatch test results using the method were obtained in 323 clinical samples. The sensitivity, specificity, positive predictive value, negative predictive value, and concordance rate of the crossmatch test using Microscanner C3 were 98.20%, 100.00%, 100.00%, 98.11%, and 99.07%, respectively. The diagnostic performance of the new system offers a promising alternative to conventional tube methods for pre-transfusion crossmatch testing. Microscanner C3 could also increase the automation, standardization, and accuracy of crossmatch tests. The crossmatch test using Microscanner C3 is thought to increase the efficiency and reliability in identifying blood samples suitable for transfusion, thereby improving patient safety and optimizing the use of blood products in clinical settings.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Pre-Transfusion Crossmatch Test Using Microscanner C3

Park,

Jang,

Lim

et al. 2024

Diagnostics

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“…Transfusion reactions could cause the adverse events in patients as well as a heavy financial burden on the healthcare system ( 6 ). Common transfusion reactions include allergic transfusion reaction, acute hemolytic transfusion reaction, delayed hemolytic transfusion reaction, delayed serological transfusion reaction, febrile non-hemolytic transfusion reaction (FNHTR), hypotensive transfusion reaction, sepsis transfusion reaction, transfusion-related circulatory overload, and transfusion-related acute lung injury ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Research progress on febrile non-hemolytic transfusion reaction: a narrative review

Wang¹,

Ren²,

Sun³

et al. 2022

Ann Transl Med

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Background and Objective: About 1% of patients who receive blood transfusions will develop transfusion reactions. Febrile non-hemolytic transfusion reaction (FNHTR) is the most common type of transfusion reaction. It not only leads to misdiagnosis and delayed treatment, but also incurs a huge economic burden. This article reviews FNHTR systematically, aiming to make clinicians have a more comprehensive understanding of FNHTR and reduce the occurrence of this side effect.Methods: A comprehensive search of the PubMed, Embase, and Cochrane Library databases was performed. Medical Subject Headings (MeSH) included Blood Transfusion, Transfusion Reaction, and Febrile Non-Hemolytic Transfusion Reaction. The searches and literature screening were performed by 2 researchers; any differences of opinion or results were resolved through negotiation.

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Nonlinear relationship between Hemoglobin-to-Age Ratio and all-cause mortality in patients with septic shock: A retrospective cohort study in the MIMIC-IV database

Yang,

Xue,

You

et al. 2024

PLoS ONE

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Background Previous studies have shown that both age and hemoglobin are closely associated with the prognosis of septic shock. A recent study found that hemoglobin may change with age. Hemoglobin-to-Age Ratio (HAR) takes both age and hemoglobin into consideration as essential factors. So far, the effect of HAR on the prognosis of septic shock is still unclear. This research aimed to investigate the association between the HAR and the prognosis of patients with septic shock. Methods Cox proportional hazards regression analysis, restricted cubic spline, Kaplan-Meier survivor analysis and stratified interaction analysis were used to elucidate the relationship between the HAR and prognosis of patients with septic shock. Results There is a nonlinear association between the HAR and mortality within 28 days after intensive care unit admission. When the HAR was lower than 0.13, mortality within 28 days after ICU admission decreased significantly as the HAR increased. When the HAR was higher than 0.13, the HAR was not a protective factor for mortality within 28 days after ICU admission. In patients with septic shock, the HAR was more effective in reducing the risk of death in patients with atrial fibrillation than in patients without atrial fibrillation. Conclusion There is a nonlinear association between the HAR and mortality within 28 days after intensive care unit admission. When the HAR was at a low level, mortality within 28 days after ICU admission decreased significantly as the HAR increased. When the HAR was at high levels, the HAR might not be a protective factor for mortality within 28 days after ICU admission. In patients with septic shock, the HAR was more effective in reducing the risk of death in patients with atrial fibrillation than in patients without atrial fibrillation.

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Adverse transfusion reactions and what we can do

Cited by 3 publications

References 187 publications

Evaluation of Pre-Transfusion Crossmatch Test Using Microscanner C3

Evaluation of Pre-Transfusion Crossmatch Test Using Microscanner C3

Research progress on febrile non-hemolytic transfusion reaction: a narrative review

Nonlinear relationship between Hemoglobin-to-Age Ratio and all-cause mortality in patients with septic shock: A retrospective cohort study in the MIMIC-IV database

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