Aedes albopictus (Skuse, 1894) infected with the American-Asian genotype of dengue type 2 virus in Medellín suggests its possible role as vector of dengue fever in Colombia

Gómez-Palacio, Andrés; Suaza-Vasco, Juan; Castaño, Sandra; Triana, Omar; Uribe, Sandra

doi:10.7705/biomedica.v37i0.3474

Cited by 16 publications

(12 citation statements)

References 31 publications

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“…Natural infection of Ae. albopictus with dengue and Zika viruses has already been reported [ 9 , 42 , 44 ]; however, its role as an arbovirus vector in the country should be further clarified, especially considering the results in our study. The low amount of Ae.…”

Section: Discussionmentioning

confidence: 64%

Entomovirological Surveillance in Schools: Are They a Source for Arboviral Diseases Transmission?

Pérez-Pérez

Peña-García

Calle-Tobón

et al. 2021

IJERPH

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Surveillance and control activities for virus-transmitting mosquitoes have primarily focused on dwellings. There is little information about viral circulation in heavily trafficked places such as schools. We collected and analyzed data to assess the presence and prevalence of dengue, chikungunya, and Zika viruses in mosquitoes, and measured Aedes indices in schools in Medellín (Colombia) between 2016–2018. In 43.27% of 2632 visits we collected Aedes adults, creating 883 pools analyzed by RT-PCR. 14.27% of pools yielded positive for dengue or Zika (infection rates of 1.75–296.29 for Aedes aegypti). Ae. aegypti was more abundant and had a higher infection rate for all studied diseases. Aedes indices varied over time. There was no association between Aedes abundance and mosquito infection rates, but the latter did correlate with cases of arboviral disease and climate. Results suggest schools are important sources of arbovirus and health agencies should include these sites in surveillance programs; it is essential to know the source for arboviral diseases transmission and the identification of the most population groups exposed to these diseases to research and developing new strategies.

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Section: Discussionmentioning

confidence: 64%

Entomovirological Surveillance in Schools: Are They a Source for Arboviral Diseases Transmission?

Pérez-Pérez

Peña-García

Calle-Tobón

et al. 2021

IJERPH

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“…aegypti and Ae. albopictus are infected with DENV and ZIKV [9][10][11]. Since 2000, the number of dengue cases in Medellín has increased continuously, with periodic outbreaks, and nearly 20,000 dengue cases have been reported in each of the last major outbreaks occurring in 2010 and 2016 [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…aegypti, but Ae. albopictus may potentially be a secondary vector as it can be naturally infected with DENV2 [10,32] and ZIKV [11,33]. Both Medellín and its adjacent city, Bello, sustain arboviruses at consistent rates.…”

Section: Introductionmentioning

confidence: 99%

Local-scale virome depiction supports significant differences between Aedes aegypti and Aedes albopictus

Calle-Tobón

Pérez-Pérez

Forero-Pineda

et al. 2022

Preprint

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Aedes spp. comprise the primary group of mosquitoes that transmit arboviruses such as dengue, Zika, and chikungunya viruses to humans, and thus these insects pose a significant burden on public health worldwide. Advancements in next-generation sequencing and metagenomics have expanded our knowledge on the richness of RNA viruses harbored by arthropods such as Ae. aegypti and Ae. albopictus ; increasing evidence suggests that vectorial competence can be modified by the microbiome (comprising both bacteriome and virome) of mosquitoes present in endemic zones. Using an RNA-seq-based metataxonomic approach, this study determined the virome structure of field-caught Ae. aegypti and Ae. albopictus mosquitoes in Medellín, Colombia, a municipality with a high incidence of mosquito-transmitted arboviruses. The two species are sympatric, but their core viromes differed considerably in richness, diversity, and abundance; the viromes were dominated by a few viruses. BLAST searches of assembled contigs suggested that at least 17 virus species (16 of which are insect-specific viruses [ISVs]) infect the Ae. aegypti population. Dengue virus 3 was detected in one sample. In Ae. albopictus , up to 11 ISVs and one plant virus were detected. Therefore, the virome composition was species-specific. The bacterial endosymbiont Wolbachia was identified in all Ae. albopictus samples and in some Ae. aegypti samples collected after 2017. The presence of Wolbachi a sp. in Ae. aegypti was not related to significant changes in the richness, diversity, or abundance of this mosquito’s virome, although it was related to an increase in the abundance of Aedes aegypti To virus 2 (unclassified). The mitochondrial diversity of these mosquitoes suggested that the Ae. aegypti population underwent a change that started in the second half of 2017, which coincides with the release of Wolbachia -infected mosquitoes in Medellín, indicating that the population of w Mel-infected mosquitoes has expanded. However, additional studies are required on the dispersal speed and intergenerational stability of w Mel in Medellín and nearby areas as well as on the introgression of genetic variants in the native mosquito population.

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“…aegypti as the primary vector in almost 80% of the Colombian territory, and Ae. albopictus as secondary vector in places where these species have been recently introduced [ 11 , 12 ]. Colombia is classified as hyperendemic for dengue transmission since all four serotypes are circulating throughout the country and are even within the same endemic foci [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Laboratory Findings in Patients with Probable Dengue Diagnosis from an Endemic Area in Colombia in 2018

Cardenas

Giraldo-Parra²,

González

et al. 2021

Viruses

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As demonstrated with the novel coronavirus pandemic, rapid and accurate diagnosis is key to determine the clinical characteristic of a disease and to improve vaccine development. Once the infected person is identified, hematological findings may be used to predict disease outcome and offer the correct treatment. Rapid and accurate diagnosis and clinical parameters are pivotal to track infections during clinical trials and set protection status. This is also applicable for re-emerging diseases like dengue fever, which causes outbreaks in Asia and Latin America every 4 to 5 years. Some areas in the US are also endemic for the transmission of dengue virus (DENV), the causal agent of dengue fever. However, significant number of DENV infections in rural areas are diagnosed solely by clinical and hematological findings because of the lack of availability of ELISA or PCR-based tests or the infrastructure to implement them in the near future. Rapid diagnostic tests (RDT) are a less sensitive, yet they represent a timely way of detecting DENV infections. The purpose of this study was to determine whether there is an association between hematological findings and the probability for an NS1-based DENV RDT to detect the DENV NS1 antigen. We also aimed to describe the hematological parameters that are associated with the diagnosis through each test.

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Aedes albopictus (Skuse, 1894) infected with the American-Asian genotype of dengue type 2 virus in Medellín suggests its possible role as vector of dengue fever in Colombia

Cited by 16 publications

References 31 publications

Entomovirological Surveillance in Schools: Are They a Source for Arboviral Diseases Transmission?

Entomovirological Surveillance in Schools: Are They a Source for Arboviral Diseases Transmission?

Local-scale virome depiction supports significant differences between Aedes aegypti and Aedes albopictus

Laboratory Findings in Patients with Probable Dengue Diagnosis from an Endemic Area in Colombia in 2018

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