Aerobic Endurance Training Program Improves Exercise Performance in Lung Transplant Recipients

Stiebellehner, Leopold; Quittan, Michael; End, Adelheid; Wieselthaler, Georg; Klepetko, Walter; Haber, Paul; Burghuber, Otto Chris

doi:10.1378/chest.113.4.906

Cited by 62 publications

(44 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To our knowledge, only a few studies 25,26 have examined the effects of a rehabilitation program on recipients of lung transplants. One study 25 of 11 heartlung transplant recipients used an in-hospital exercise training program lasting 20 to 70 days and consisting of supervised incremental treadmill walking, inspiratory muscle training, abdominal muscle training and upperand lower-extremity weight training.…”

Section: Discussionmentioning

confidence: 99%

Limiting Factors of Exercise Performance 1 Year After Lung Transplantation

Reinsma

Hacken

Grevink

et al. 2006

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

Background: After lung transplantation (LTx) exercise capacity frequently remains limited, despite significantly improved pulmonary function. The aim of this study was to evaluate maximal exercise capacity and peripheral muscle force before and 1 year after LTx, and to determine whether peripheral muscle force and lactate threshold (LT) limit exercise capacity 1 year after LTx. Methods:Twenty-five subjects (mean age 43 years, 8 women and 17 men, 4 single-lung transplantations) were included in the study. Measurements included maximal exercise capacity, lactate threshold (symptom-limited bicycle ergometer test) and muscle force test (hand-held dynamometer) were performed before and 1 year after LTx. Results:Before LTx, all patients showed severe exercise intolerance (mean Ϯ SD): work capacity (W peak ), 11.6 Ϯ 18 W; peak oxygen uptake (VO 2 ), 8.6 Ϯ 3.6 ml/min/kg. After LTx, exercise capacity improved significantly: W peak , 69 Ϯ 27 W (p Ͻ 0.001); peak VO 2 , 15.7 Ϯ 4.3 ml/min/kg (p Ͻ 0.001). Ventilatory factors did not appear to limit exercise capacity. Quadriceps muscle force pre-vs post-LTx was: 248 Ϯ 73 N vs 281 Ϯ 68 N (p Ͻ 0.05). Post-LTx, a significant correlation was found between LT and exercise capacity (r ϭ 0.76, p Ͻ 0.001), between muscle force and exercise capacity (r ϭ 0.41, p Ͻ 0.05) and between the LT and muscle force (r ϭ 0.53, p Ͻ 0.01). Conclusions:The occurrence of an early and pathologic LT and peripheral muscle weakness contributes to the limitation of exercise capacity and reflects a peripheral deficit post-LTx.

show abstract

Section: Discussionmentioning

confidence: 99%

Limiting Factors of Exercise Performance 1 Year After Lung Transplantation

Reinsma

Hacken

Grevink

et al. 2006

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

show abstract

“…Hence, one could anticipate that adaptation to training at the level of skeletal muscle should be possible following transplantation with resultant improvements in exercise capacity. Few studies have examined the effects of exercise training following LT. Aerobic exercise training has been shown to result in modest improvements in peak exercise performance in LT [89] and HLT recipients [90], although the subjects remained with significant aerobic impairment post-training. The implications for impaired exercise performance following LT remain unclear, since recipients unquestionably experience substantial improvements in functional capacity and QoL [3].…”

Section: Exercise Performancementioning

confidence: 99%

Lung transplant outcomes: a review of survival, graft function, physiology, health-related quality of life and cost-effectiveness

Studer¹

2004

Eur Respir J

163

View full text Add to dashboard Cite

The success of lung transplantation has improved over time as evidenced by better long-term survival and functional outcomes. Despite the success of this procedure, there are numerous problems and complications that may develop over the life of a lung transplant recipient. With proper monitoring and treatment, the frequency and severity of these problems can be decreased. However, significant improvement for the overall outcomes of lung transplantation will only occur when better methods exist to prevent or effectively treat chronic rejection. Eur Respir J 2004; 24: 674-685.

show abstract

“…Nevertheless, the role of NPPV in pulmonary rehabilitation, if any, is still to be defined. In fact, the recent development of new therapeutic approaches like lung transplantation and lung volume reduction surgery make patients with severe COPD, even with chronic respiratory failure, candidates to rehabilitation programmes [59,60].…”

Section: Nppv and Pulmonary Rehabilitationmentioning

confidence: 99%

New strategies to improve exercise tolerance in chronic obstructive pulmonary disease

Ambrosino¹,

Strambi²

2004

Eur Respir J

137

106

View full text Add to dashboard Cite

Breathlessness is the most common symptom limiting exercise in patients with chronic obstructive pulmonary disease (COPD). Exercise training can improve both exercise tolerance and health status in these patients, intensity being of key importance. Nevertheless, in these patients extreme breathlessness and/or peripheral muscle fatigue may prevent patients from higher levels of intensity. In this review article the literature concerning the different ways to optimise exercise tolerance in patients with COPD, with the objective of enhancing the tolerance to higher exercise training intensity, is summarised.Continuous positive airway pressure and different modalities of noninvasive positive pressure ventilation (NPPV) may reduce breathlessness and increase exercise tolerance in these patients. Respiratory muscle unloading and reduction in intrinsic positive end-expiratory pressure have been considered among mechanisms underlying these effects. Nevertheless, the role of NPPV in pulmonary rehabilitation, if any, is still controversial. The addition of nocturnal domiciliary NPPV during a daily exercise programme in patients with severe COPD resulted in an improvement in exercise tolerance and quality of life.In patients with severe COPD application of electrical stimulation combined with active limb mobilisation significantly improved muscle strength, and interval training has been shown capable of inducing physiological training effects.Oxygen supplementation in patients who do not desaturate during exercise seems to be the most promising treatment, since it allows for higher exercise intensities and, therefore, superior training efficacy.In conclusion, further studies are needed to define the appropriate patients in order to generalise such interventions. The modalities discussed should be used as adjuncts to a well designed comprehensive respiratory rehabilitation programme.

show abstract

Aerobic Endurance Training Program Improves Exercise Performance in Lung Transplant Recipients

Cited by 62 publications

References 24 publications

Limiting Factors of Exercise Performance 1 Year After Lung Transplantation

Limiting Factors of Exercise Performance 1 Year After Lung Transplantation

Lung transplant outcomes: a review of survival, graft function, physiology, health-related quality of life and cost-effectiveness

New strategies to improve exercise tolerance in chronic obstructive pulmonary disease

Contact Info

Product

Resources

About