Aerobic exercise training alleviates renal injury in db/db mice through inhibiting Nox4-mediated NLRP3 inflammasome activation

Zhou, Zhongyuan; Ying, Changjiang; Zhou, Xiaoyan; Shi, Yuanyuan; Xu, Jian; Zhu, Yandong; Wang, Meng; Li, Yan; Li, Xiaofei; Xiang, Jie

doi:10.1016/j.exger.2022.111934

Cited by 10 publications

(7 citation statements)

References 52 publications

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“…Aerobic exercise training decreased the levels of Nox4, ROS, TNF-α, MCP-1, IL-6, and the expression of NLRP3, ASC, caspase-1 p20, and IL-1β and IL-18. These results demonstrate that aerobic exercise exerts a renoprotective effect by inhibition of the Nox4/ROS/NF-κB/NLRP3 axis ( 102 ).…”

Section: Exercise On Improving Diabetic Complications By Targeting Py...mentioning

confidence: 73%

Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications

Li,

Zhang,

Wang

et al. 2023

Front. Endocrinol.

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Diabetes mellitus (DM) and its complications are important, worldwide public health issues, exerting detrimental effects on human health and diminishing both quality of life and lifespan. Pyroptosis, as a new form of programmed cell death, plays a critical role in DM and its complications. Exercise has been shown to be an effective treatment for improving insulin sensitivity or preventing DM. However, the molecular mechanisms underlying the effects of exercise on pyroptosis-related diseases remain elusive. In this review, we provided a comprehensive elucidation of the molecular mechanisms underlying pyroptosis and the potential mechanism of exercise in the treatment of DM and its complications through the modulation of anti-pyroptosis-associated inflammasome pathways. Based on the existing evidence, further investigation into the mechanisms by which exercise inhibits pyroptosis through the regulation of inflammasome pathways holds promising potential for expanding preventive and therapeutic strategies for DM and facilitating the development of novel therapeutic interventions.

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Section: Exercise On Improving Diabetic Complications By Targeting Py...mentioning

confidence: 73%

Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications

Li,

Zhang,

Wang

et al. 2023

Front. Endocrinol.

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“…From molecular mechanisms in the cell, the key factors in exercise-mediated improvement of CVD through the NLRP3 inflammasome may be related to the regulation of the NF-κB signaling pathway. Some studies have focused on the NF-κB pathway as a critical node to explore the molecular mechanisms among exercise and NLRP3 inflammasome (Wang et al, 2019;Zhou et al, 2022). For example, research has demonstrated that aerobic exercise is capable of reducing the expression of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4), ROS, TNF-α, IL-18, NF-κB p65, and the NLRP3 inflammasome (Zhou et al, 2022).…”

Section: Mechanisms By Which Exercise Regulates Nlrp3 Inflammasome Ac...mentioning

confidence: 99%

“…Some studies have focused on the NF-κB pathway as a critical node to explore the molecular mechanisms among exercise and NLRP3 inflammasome (Wang et al, 2019;Zhou et al, 2022). For example, research has demonstrated that aerobic exercise is capable of reducing the expression of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4), ROS, TNF-α, IL-18, NF-κB p65, and the NLRP3 inflammasome (Zhou et al, 2022). These findings suggest that exercise may ameliorate the pathological alterations in diabetes mellitus through the modulation of the NOX4/ROS/NF-κB/NLRP3 inflammasome signaling cascade (Zhou et al, 2022).…”

Section: Mechanisms By Which Exercise Regulates Nlrp3 Inflammasome Ac...mentioning

confidence: 99%

“…For example, research has demonstrated that aerobic exercise is capable of reducing the expression of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4), ROS, TNF-α, IL-18, NF-κB p65, and the NLRP3 inflammasome (Zhou et al, 2022). These findings suggest that exercise may ameliorate the pathological alterations in diabetes mellitus through the modulation of the NOX4/ROS/NF-κB/NLRP3 inflammasome signaling cascade (Zhou et al, 2022). In a separate study, Wang et al, 2019 observed that aerobic exercise suppresses the acetylation of forkhead box transcription factor O1 (FOXO1) in the brain tissue of diabetic rats, which in turn promotes the phosphorylation of FOXO1, thus inhibiting expression of NF-κB and NLRP3 inflammasome protein.…”

Section: Mechanisms By Which Exercise Regulates Nlrp3 Inflammasome Ac...mentioning

confidence: 99%

“…This downregulation contributes to the inhibition of inflammatory responses, indicating that exercise may exert anti-inflammatory effects via the FOXO1/NF-κB/ NLRP3 inflammasome pathway (Wang et al, 2019). Although studies have shown that exercise improves CVD through the NLRP3 inflammasome Zhou et al, 2022), further research is needed to elucidate the detailed molecular mechanisms by which exercise regulates the NLRP3 inflammasome.…”

Section: Mechanisms By Which Exercise Regulates Nlrp3 Inflammasome Ac...mentioning

confidence: 99%

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NLRP3 inflammasome and pyroptosis in cardiovascular diseases and exercise intervention

Ding,

Song,

Yang

et al. 2024

Front. Pharmacol.

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NOD-like receptor protein 3 (NLRP3) inflammasome is an intracellular sensing protein complex that possesses NACHT, leucine-rich repeat, and pyrin domain, playing a crucial role in innate immunity. Activation of the NLRP3 inflammasome leads to the production of pro-inflammatory cellular contents, such as interleukin (IL)-1β and IL-18, and induction of inflammatory cell death known as pyroptosis, thereby amplifying or sustaining inflammation. While a balanced inflammatory response is beneficial for resolving damage and promoting tissue healing, excessive activation of the NLRP3 inflammasome and pyroptosis can have harmful effects. The involvement of the NLRP3 inflammasome has been observed in various cardiovascular diseases (CVD). Indeed, the NLRP3 inflammasome and its associated pyroptosis are closely linked to key cardiovascular risk factors including hyperlipidemia, diabetes, hypertension, obesity, and hyperhomocysteinemia. Exercise compared with medicine is a highly effective measure for both preventing and treating CVD. Interestingly, emerging evidence suggests that exercise improves CVD and inhibits the activity of NLRP3 inflammasome and pyroptosis. In this review, the activation mechanisms of the NLRP3 inflammasome and its pathogenic role in CVD are critically discussed. Importantly, the purpose is to emphasize the crucial role of exercise in managing CVD by suppressing NLRP3 inflammasome activity and proposes it as the foundation for developing novel treatment strategies.

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Nox4 is involved in acute kidney injury associated to intravascular hemolysis

García-Caballero,

Guerrero-Hue,

Vallejo-Mudarra

et al. 2024

Free Radical Biology and Medicine

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Aerobic exercise training alleviates renal injury in db/db mice through inhibiting Nox4-mediated NLRP3 inflammasome activation

Cited by 10 publications

References 52 publications

Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications

Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications

NLRP3 inflammasome and pyroptosis in cardiovascular diseases and exercise intervention

Nox4 is involved in acute kidney injury associated to intravascular hemolysis

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