Aerobic Training Efficacy in Inflammation, Neurotrophins, and Function in Chronic Stroke Persons: A Randomized Controlled Trial Protocol

Oliveira, Daniela Matos Garcia; Aguiar, Larissa Tavares; Limones, Marcus Vinícius de Oliveira; Gomes, Aline Gonçalves; Silva, Luana Cristina da; Faria, Christina Danielli Coelho de Morais; Scalzo, Paula Luciana

doi:10.1016/j.jstrokecerebrovasdis.2018.10.016

Cited by 15 publications

(8 citation statements)

References 44 publications

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“…Moreover, patients with better nutritional status had a lower thrombosis incidence which is recognized as a risk of cerebrovascular disease [ 67 ], e.g., stroke caused by COVID-19 infection [ 68 ]. Equally important to a healthy diet, physical activity has the potential to improve inflammatory status and mobility in chronic stroke patients [ 69 ]. Inflammation is common in several chronic diseases [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Physical Activity and Diet Quality Modify the Association between Comorbidity and Disability among Stroke Patients

Nguyen

Binh

et al. 2021

Nutrients

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Background: Comorbidity is common and causes poor stroke outcomes. We aimed to examine the modifying impacts of physical activity (PA) and diet quality on the association between comorbidity and disability in stroke patients. Methods: A cross-sectional study was conducted on 951 stable stroke patients in Vietnam from December 2019 to December 2020. The survey questionnaires were administered to assess patients’ characteristics, clinical parameters (e.g., Charlson Comorbidity Index items), health-related behaviors (e.g., PA using the International Physical Activity Questionnaire- short version), health literacy, diet quality (using the Dietary Approaches to Stop Hypertension Quality (DASH-Q) questionnaire), and disability (using the World Health Organization Disability Assessment Schedule II (WHODAS II)). Linear regression models were used to analyze the associations and interactions. Results: The proportion of comorbidity was 49.9% (475/951). The scores of DASH-Q and WHODAS II were 29.2 ± 11.8, 32.3 ± 13.5, respectively. Patients with comorbidity had a higher score of disability (regression coefficient, B, 8.24; 95% confidence interval, 95%CI, 6.66, 9.83; p < 0.001) as compared with those without comorbidity. Patients with comorbidity and higher tertiles of PA (B, −4.65 to −5.48; p < 0.05), and a higher DASH-Q score (B, −0.32; p < 0.001) had a lower disability score, as compared with those without comorbidity and the lowest tertile of PA, and the lowest score of DASH-Q, respectively. Conclusions: Physical activity and diet quality significantly modified the negative impact of comorbidity on disability in stroke patients. Strategic approaches are required to promote physical activity and healthy diet which further improve stroke rehabilitation outcomes.

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Section: Discussionmentioning

confidence: 99%

Physical Activity and Diet Quality Modify the Association between Comorbidity and Disability among Stroke Patients

Nguyen

Binh

et al. 2021

Nutrients

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“…In the PPI system analysis, STAT3, APP, EDN1, TNF, AGTR1, VEGFA, IL6, F2, MMP9, and HTR2C were considered to be crucial targets. TNF, a cytokine related to a severe stage of systemic inflammation, is substantially raised in patients with ischemic and hemorrhagic stroke [ 28 ]. Besides, VEGFA is a member of the VEGF family of proteins [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio‐Cerebral Vascular Diseases

Wang

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. This study is aimed to analyze the active ingredients, drug targets, and related pathways in the combination of Salvia miltiorrhiza (SM) and Radix puerariae (RP) in the treatment of cardio-cerebral vascular diseases (CCVDs). Method. The ingredients and targets of SM and RP were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the disease targets were obtained from Therapeutic Target Database (TTD), National Center for Biotechnology Information (NCBI), and Online Mendelian Inheritance in Man (OMIM) Database. The synergistic mechanisms of the SM and RP were evaluated by gene ontology (GO) enrichment analyses and Kyoto encyclopedia of genes and genomes (KEGG) path enrichment analyses. Result. A total of 61 active ingredients and 58 common targets were identified in this study. KEGG pathway enrichment analysis results showed that SM- and RP-regulated pathways were mainly inflammatory processes, immunosuppression, and cardiovascular systems. The component-target-pathway network indicated that SM and RP exert a synergistic mechanism for CCVDs through PTGS2 target in PI3k-Akt, TNF, and Jak-STAT signaling pathways. Conclusion. In summary, this study clarified the synergistic mechanisms of SM and RP, which can provide a better understanding of effect in the treatment of CCVDs.

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“…HIF1A can up-regulate the gene expression of proteins related to the vascular system and promote the angiogenesis of VEGF and its receptors to increase blood ow and reduce ischemic injury [33]. TNF is a typical cytokine involved in the acute phase of systemic in ammation and is closely related to the severity of cerebral ischemia [34]. IL-10 is a potent anti-in ammatory mediator, and, if overexpressed, can suppress neuronal degeneration [35].…”

Section: Discussionmentioning

confidence: 99%

Study on the Mechanism of Buyang Huanwu Decoction for the treatment of Ischemic Stroke Based on Network Pharmacology

Wang¹,

Lü²,

Cao³

et al. 2020

Preprint

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Background: Buyang Huanwu Decoction (BYHWD) is one of the representative prescriptions for tonifying qi and promoting blood circulation. This formula has been widely used in Chinese clinical practice for treatment and prevention of ischemic cerebral vascular diseases. However, the mechanism and active compounds of BYHWD used in clinical practice for ischemic stroke are not well understood. The purpose of this study was to understand the potential active components of BYHWD and further explore its mechanism of improving ischemic stroke. Methods: This study was based on network pharmacology and bioinformatics analysis. The compounds of BYHWD were obtained from public databases. Oral bioavailability as well as drug-likeness were screened by using absorption, distribution, metabolism, and excretion (ADME) criteria. Then, components of BYHWD, candidate targets of each component and known therapeutic targets of ischemic cerebral were collected. A network of compound-target genes and compound-ischemic cerebral was established by means of network pharmacology data sources. The enrichment of key targets and pathways was analyzed by using string database and DAVID database. In addition, we verified three key targets predicted by western blot analysis (IL6, VEGFA and HIF1A). Results: Network pharmacology analysis results of BYHWD identified 7 herbs, 42 compounds and 79 target genes associated to cerebral ischemia. The 10 key compounds were baicalein, beta-carotene, Baicalin, kaempferol, luteolin, quercetin, hydroxysafflor yellow A, isorhamnetin, Bifendate, formononetin,Calycosin, AstragalosideIV, Stigmasterol, sitosterol, Z-ligustilide, Dihydrocapsaicin. Core genes in this network were IL6, TNF, VEGFA, HIF1A, MAPK1, MAPK3, JUN, STAT3, IL1B and IL10. And pathways TNF, IL-17, Apoptosis, PI3K-Akt, Toll-like receptor, MAPK, NF-kappa B and HIF-1 signaling pathway, etc. related to ischemic stroke were identified. In vitro experiments, The results showed that compared with the control group (no treatment), BYHWD could significantly inhibit the expression of IL6 and increased the expression of HIF1A and VEGFA. Conclusions: Network pharmacology analysis can reveal close interactions between multi-components and multi-targets, and enhance our understanding of the potential effects of BYHWD in cerebral ischemia.

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Aerobic Training Efficacy in Inflammation, Neurotrophins, and Function in Chronic Stroke Persons: A Randomized Controlled Trial Protocol

Cited by 15 publications

References 44 publications

Physical Activity and Diet Quality Modify the Association between Comorbidity and Disability among Stroke Patients

Physical Activity and Diet Quality Modify the Association between Comorbidity and Disability among Stroke Patients

A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio‐Cerebral Vascular Diseases

Study on the Mechanism of Buyang Huanwu Decoction for the treatment of Ischemic Stroke Based on Network Pharmacology

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