Aerosil‐Supported Ionic‐Liquid‐Phase (ASILP) Mediated Synthesis of 2‐Substituted Benzimidazole Derivatives as AChE Inhibitors

Sonawane, Babasaheb D; Rashinkar, Gajanan; Sonawane, Kailas D.; Dhanavade, Maruti J.; Sonawane, Vikas D.; Patil, S. V.

doi:10.1002/slct.201702969

Cited by 9 publications

(3 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2018, a team of researchers led by Sonawane [53] made a significant contribution to the field of organic chemistry by developing a novel method for synthesizing pyrano[2,3‐ d ] pyrimidinediones, a class of organic compounds denoted as 18 in their study. The method they developed is characterized by its use of zirconocene dichloride (Cp 2 ZrCl 2 ) as a catalyst.…”

Section: Synthetic Techniques For the Preparation Of Pyrano[23‐d]pyri...mentioning

confidence: 99%

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

Rezaeifard,

Bakherad,

Navidpour

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

Due to their extensive applications in pharmaceuticals and natural substances, organic synthesis and heterocyclic compounds have been at the forefront of research for many years. Pyrimidine is one of the heterocyclic compounds that have various derivatives with promising biological and pharmacological properties. This review article covers the synthesis and biological effects of pyrimidine derivatives, such as pyrano[2,3‐d]pyrimidines, pyrido[2,3‐d]pyrimidines, and furo[2,3‐d]pyrimidines. The compounds discussed in this review have a wide range of biological activities. Recent advances in green chemistry have led to the development of eco‐friendly synthetic methods for producing these bioactive heterocycles. This review aims to present various synthetic methods and biological effects of these compounds and provide new opportunities for organic chemists to develop potent nitrogen‐ and oxygen‐containing heterocycles for future applications. The review highlights examples of successful syntheses and applications of pyrimidine derivatives in the fields of antibacterial, antifungal, anticancer, enzyme inhibition, and antiviral research.

show abstract

Section: Synthetic Techniques For the Preparation Of Pyrano[23‐d]pyri...mentioning

confidence: 99%

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

Rezaeifard,

Bakherad,

Navidpour

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…The imidazolium liquids are among the most popular ionic liquids applied in the SILP systems, and this brings about continuous improvement in the systems in which they are employed. An example is a new system with the use of [BMIM]PF 6 and pyrogenic amorphous Aerosil silica, which was applied as a catalyst for the synthesis of benzimidazole-the compound that has fungicidal properties [76].…”

Section: Supported Ionic Liquid Phase Catalysts (Silpcs)mentioning

confidence: 99%

Heterogeneous Catalysis with the Participation of Ionic Liquids

et al. 2020

View full text Add to dashboard Cite

This mini-review briefly describes the recent progress in the design and development of catalysts based on the presence of ionic liquids. In particular, the focus was on heterogeneous systems (supported ionic liquid (IL) phase catalysts (SILPC), solid catalysts with ILs (SCILL), porous liquids), which due to the low amounts of ionic liquids needed for their production, eliminate basic problems observed in the case of the employment of ionic liquids in homogeneous systems, such as high price, high viscosity, and efficient isolation from post-reaction mixtures.

show abstract

“…Also, the prepared benzimidazoles revealed good antifungal activity against Candida albicans (NCIM-3466) and Aspergiillus niger (NCIM-3495). Additionally, molecular docking studies of synthesized benzimidazoles revealed hydrogen bonding interactions with receptor enzyme of acetylcholinesterase (AChE) and so prepared benzimidazoles act as inhibitors for AChE [39].…”

Section: Scheme-14: Reaction For the Synthesis Of 2-phenyl-1h-benzimimentioning

confidence: 99%

Graphene Oxide: An Efficient and Recyclable Nano Catalyst for the Synthesis of 2-Substituted Benzimidazoles from Aldehydes and Diamines at Ambient Temperature

Moniri¹,

Behbahani²

2019

SIJCMS

View full text Add to dashboard Cite

The benzimidazoles skeleton, a category of heterocyclic compounds have important biological and pharmaceutical properties such as antihelminthic, antiulcer, diuretic, anticonvulsant, analgesic, antiulcer, antihypertensive, anticoagulant, anticancer, anti-inflammatory, antimicrobial, antiviral, antiparasitic and antioxidant. On the other hand, graphene oxide due to their operational simplicity, easy work up and inherent non-toxic, and possessing a wide variety of functional groups, such as epoxy, hydroxyl, and carboxyl, pays an important role in organic synthesis. Therefore, in this chapter graphene oxide was investigated as an efficient catalytic system for the preparation of benzimidazole compounds via the condensation reaction of o-phenylenediamines with aromatic aldehydes in very good yields at ambient temperature. The results in this method were compared with previously reported in literature respectively. Also graphene oxide was recovered and reused without decreasing in its efficacy for 3 th runs.

show abstract

Aerosil‐Supported Ionic‐Liquid‐Phase (ASILP) Mediated Synthesis of 2‐Substituted Benzimidazole Derivatives as AChE Inhibitors

Cited by 9 publications

References 56 publications

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

Heterogeneous Catalysis with the Participation of Ionic Liquids

Graphene Oxide: An Efficient and Recyclable Nano Catalyst for the Synthesis of 2-Substituted Benzimidazoles from Aldehydes and Diamines at Ambient Temperature

Contact Info

Product

Resources

About