Aerosol flow reactor method for synthesis of drug nanoparticles

Investigations on the Humidity-Induced Transformations of Salbutamol Sulphate Particles Coated with l-Leucine

“…Particle preparation in the aerosol flow reactor (25,26) consists of the generation of droplets, drying of particles, and coating of dry solid particles via the physical vapour deposition (PVD) of L-leucine. Solute droplets from the precursor solutions were formed using an ultrasonic nebulizer (RBI Pyrosol 7901, France) equipped with an internal water circulator to keep the temperature of the solutions constant at 20 (±1)°C.…”

Surface modification of acetaminophen particles by atomic layer deposition

“…They did not report the film thickness on particles due to an inability to perform thickness estimation, resulting from the non-uniform nature of the particle surfaces (Singh et al, 2002). A modified spray drying method, which can be used both for drug particle synthesis and particle coating by physical vapour deposition, has been developed and studied for synthesizing drug particles (Eerikäinen et al, 2003), for coating salbutamol sulfate particles with L-leucine (Raula et al, 2008), for encapsulating indomethacin nanocrystals in mannitol microparticles with an L-leucine coating , and for combining budesonide and salbutamol in microparticles coated with L-leucine (Raula et al, 2013;Vartiainen et al, 2016). In this method, APIs, binders and coating material are dissolved in water to form a precursor solution which is used in an aerosol process.…”

What is a Suitable Dissolution Method for Drug Nanoparticles?

“…micronization or nano-sizing) are crucial for realizing better bioavailability of drugs with poor dissolution (9). Current strategies for engineering drug nanoparticles include the use of supercritical fluids (10), aerosols (11), highgravity reactive/antisolvent precipitation (12), microemulsification (13), and confined impinging jets (14).…”