2023
DOI: 10.1038/s41418-023-01172-7
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AF9 targets acetyl-modified STAT6 to diminish purine metabolism and accelerate cell apoptosis during metastasis

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“…Approximately 50–90% of human proteins, including various tumor proteins and tumor suppressors, undergo PTM (Ray et al 2015 ). For instance, STAT6 acetylation can inhibit the migration and invasion of KIRC cells and contribute to the survival of KIRC patients (Shao et al 2023 ). S-palmitoylation, a reversible form of PTM, can modify protein secretion, transport, and interaction, and membrane trafficking and stability (Wu et al 2021a , b ).…”
Section: Introductionmentioning
confidence: 99%
“…Approximately 50–90% of human proteins, including various tumor proteins and tumor suppressors, undergo PTM (Ray et al 2015 ). For instance, STAT6 acetylation can inhibit the migration and invasion of KIRC cells and contribute to the survival of KIRC patients (Shao et al 2023 ). S-palmitoylation, a reversible form of PTM, can modify protein secretion, transport, and interaction, and membrane trafficking and stability (Wu et al 2021a , b ).…”
Section: Introductionmentioning
confidence: 99%