Afferent connections of the dorsal, perigenual, and subgenual anterior cingulate cortices of the monkey: Amygdalar inputs and intrinsic connections

Kim, Yuri; Sakata, Honami; Nejime, Masafumi; Konoike, Naho; Miyachi, Shigehiro; Nakamura, Katsuki

doi:10.1016/j.neulet.2018.05.028

Cited by 14 publications

(24 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, neuroanatomical studies have shown that the ACC receives strong cortical and subcortical inputs from the anterior temporal lobe (Moran et al, 1987; Vogt and Pandya, 1987; Amaral et al, 1992; Carmichael and Price, 1995; Barbas et al, 1999; Ghashghaei and Barbas, 2002; Saleem et al, 2008; Morecraft et al, 2012; Joyce and Barbas, 2018). Previously, we analyzed the organization of afferent inputs from the amygdala (Kim et al, 2018) to the pgACC, sgACC, and dACC and found that the sgACC received rich inputs from the accessory basal and lateral nuclei, in which neuronal responses selective for face and those selective for negative stimuli were recorded (Leonard et al, 1985; Nishijo et al, 1988; Boll et al, 2011). Besides the amygdala, the temporal cortex, especially its anterior and medial regions, is also crucial for the recognition of faces and other complex visual stimuli (Perrett et al, 1982; Kobatake and Tanaka, 1994; Nakamura et al, 1994; Browning et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…In the present study, we used the same animals that were used in our previous work (Kim et al, 2018) to compare the neuronal inputs to the three ACC regions from the anterior temporal cortex, including the hippocampus. In addition to the distribution pattern of the labeled neurons, the laminar distribution in each area was also examined to determine the hierarchical organization of these areas and the direction of the flow of information.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Laminar Pattern of Projections Indicates the Hierarchical Organization of the Anterior Cingulate-Temporal Lobe Emotion System

et al. 2019

Self Cite

View full text Add to dashboard Cite

The anterior cingulate cortex (ACC), surrounding the genu of the corpus callosum, plays important roles in emotional processing and is functionally divided into the dorsal, perigenual, and subgenual subregions (dACC, pgACC, and sgACC, respectively). Previous studies have suggested that the pgACC and sgACC have distinctive roles in the regulation of emotion. In order to elicit appropriate emotional responses, these ACC regions require sensory information from the environment. Anatomically, the ACC has rich connections with the temporal lobe, where the higher-order processing of sensory information takes place. To clarify the organization of sensory inputs into the ACC subregions, we injected neuronal tracers into the pgACC, sgACC, and dACC and compared the afferent connections. Previously, we analyzed the afferent projections from the amygdala and found a distinct pattern for the sgACC. In the present study, the patterns of the afferent projections were analyzed in the temporal cortex, especially the temporal pole (TP) and medial temporal areas. After tracers were injected into the sgACC, we observed labeled neurons in the TP and the subiculum of the hippocampal formation. The majority of the labeled cell bodies were found in the superficial layers of the TP (“feedforward” type projections). The pgACC received afferent projections from the TP, the entorhinal cortex (EC), and the parahippocampal cortex (PHC), but not from the hippocampus. In each area, the labeled cells were mainly found in the deep layers (“feedback” type projection). The pattern for the dACC was similar to that for the pgACC. Previous studies suggested that the pgACC, but not the sgACC receive projections from the dorsolateral prefrontal cortex (DLPFC). These data suggest that the sgACC plays crucial roles for emotional responses based on sensory and mnemonic inputs from the anterior temporal lobe, whereas the pgACC is more related to the cognitive control of emotion.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Laminar Pattern of Projections Indicates the Hierarchical Organization of the Anterior Cingulate-Temporal Lobe Emotion System

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the ACC receives no direct input from the primary visual cortex (Vogt and Pandya, 1987 ). These responses may be induced by subcortical visual input including pulvinar or amygdala (Romanski et al, 1997 ; Pessoa and Adolphs, 2010 ; Kim et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, the amygdala is thought to be involved in the processing of emotional signals (Murray, 2007 ; Pessoa and Adolphs, 2010 ). Also, neuronal tracing in macaques has revealed that the ACC has rich neuronal connections with other limbic structures, including the amygdala (Amaral and Price, 1984 ; Barbas and De Olmos, 1990 ; Kunishio and Haber, 1994 ; Carmichael and Price, 1995 , 1996 ; Ghashghaei and Barbas, 2002 ; Kim et al, 2018 ). These results suggest that the ACC receives emotional information from other limbic regions and functions in a regulatory role concerning the amygdala.…”

Section: Discussionmentioning

confidence: 99%

“…Although the cingulate cortex is one of the major components of the primate limbic system, the responsiveness of cingulate cortex neurons to conspecifics’ faces is still unclear. Neuronal tracing studies in macaque monkeys revealed that the ACC has rich neuronal connections with other limbic structures including the amygdala (Amaral and Price, 1984 ; Barbas and De Olmos, 1990 ; Kunishio and Haber, 1994 ; Carmichael and Price, 1995 , 1996 ; Ghashghaei and Barbas, 2002 ; Kim et al, 2018 ), as well as other prefrontal regions (Saleem et al, 2008 ). Several neuroimaging studies have reported that perception of negative facial expressions modulates the neuronal activity in the ACC (Blair et al, 1999 ) and amygdala (Blair et al, 1999 ) in humans.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potent and Quick Responses to Conspecific Faces and Snakes in the Anterior Cingulate Cortex of Monkeys

Konoike

Iwaoki

Nakamura

2020

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

Appropriate processing of others’ facial emotions is a fundamental ability of primates in social situations. Several moods and anxiety disorders such as depression cause a negative bias in the perception of facial emotions. Depressive patients show abnormalities of activity and gray matter volume in the perigenual portion of the anterior cingulate cortex (ACC) and an increase of activation in the amygdala. However, it is not known whether neurons in the ACC have a function in the processing of facial emotions. Furthermore, detecting predators quickly and taking avoidance behavior are important functions in a matter of life and death for wild monkeys. the existence of predators in their vicinity is life-and-death information for monkeys. In the present study, we recorded the activity of single neurons from the monkey ACC and examined the responsiveness of the ACC neurons to various visual stimuli including monkey faces, snakes, foods, and artificial objects. About one-fourth of the recorded neurons showed a significant change in activity in response to the stimuli. The ACC neurons exhibited high selectivity to certain stimuli, and more neurons exhibited the maximal response to monkey faces and snakes than to foods and objects. The responses to monkey faces and snakes were faster and stronger compared to those to foods and objects. Almost all of the neurons that responded to video stimuli responded strongly to negative facial stimuli, threats, and scream. Most of the responsive neurons were located in the cingulate gyrus or the ventral bank of the cingulate sulcus just above or anterior to the genu of the corpus callosum, that is, the perigenual portion of the ACC, which has a strong mutual connection with the amygdala. These results suggest that the perigenual portion of the ACC in addition to the amygdala processes emotional information, especially negative life-and-death information such as conspecifics’ faces and snakes.

show abstract

Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex

Calderazzo

Busch

Moore

et al. 2020

J of Comparative Neurology

View full text Add to dashboard Cite

The anterior cingulate cortex (ACC) is important for decision-making as it integrates motor plans with affective and contextual limbic information. Disruptions in these networks have been observed in depression, bipolar disorder, and post-traumatic stress disorder. Yet, overlap of limbic and motor connections within subdivisions of the ACC is not well understood. Hence, we administered a combination of retrograde and anterograde tracers into structures important for contextual memories (entorhinal cortex), affective processing (amygdala), and motor planning (dorsal premotor cortex) to assess overlap of labeled projection neurons from (outputs) and axon terminals to (inputs) the ACC of adult rhesus monkeys (Macaca mulatta). Our data show that entorhinal and dorsal premotor cortical (dPMC) connections are segregated across ventral (A25, A24a) and dorsal (A24b,c) subregions of the ACC, while amygdalar connections are more evenly distributed across subregions. Among all areas, the rostral ACC (A32) had the lowest relative density of connections with all three regions. In the ventral ACC, entorhinal and amygdalar connections strongly overlap across all layers, especially in A25. In the dorsal ACC, outputs to dPMC and the amygdala strongly overlap in deep layers. However, dPMC input to the dorsal ACC was densest in deep layers, while amygdalar inputs predominantly localized in upper layers. These connection patterns are consistent with diverse roles of the dorsal ACC in motor evaluation and the ventral ACC in affective and contextual memory. Further, distinct laminar circuits suggest unique interactions within specific ACC compartments that are likely important for the temporal integration of motor and limbic information during flexible goal-directed behavior.

show abstract

Afferent connections of the dorsal, perigenual, and subgenual anterior cingulate cortices of the monkey: Amygdalar inputs and intrinsic connections

Cited by 14 publications

References 29 publications

Laminar Pattern of Projections Indicates the Hierarchical Organization of the Anterior Cingulate-Temporal Lobe Emotion System

Laminar Pattern of Projections Indicates the Hierarchical Organization of the Anterior Cingulate-Temporal Lobe Emotion System

Potent and Quick Responses to Conspecific Faces and Snakes in the Anterior Cingulate Cortex of Monkeys

Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex

Contact Info

Product

Resources

About