AFG, an important maillard reaction product in red ginseng, alleviates D-galactose-induced brain aging in mice via correcting mitochondrial dysfunction induced by ROS accumulation

Zhang, Jun-jie; Chen, Ke-cheng; Yin, Ji-ying; Zheng, Yi-nan; Chen, Ri-xin; Liu, Wei; Tang, Shan; Zhang, Jing; Zhang, Ming; Wang, Zi; Liu, Shuang; Li, Wei

doi:10.1016/j.ejphar.2023.175824

Cited by 8 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, without the supplementation of exogenous antioxidants, the excessive ROS may result in neurological decline or cognitive dysfunction in the brain, such as Alzheimer’s disease, neurodegenerative disease, etc. [ 40 ]. Particularly, the damage to the CA1, CA2, CA3, and DG regions in the brain will directly affect the transition of information from short-term to long-term memory.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway

Wang,

Zhao

et al. 2024

Molecules

View full text Add to dashboard Cite

Que Zui tea (QT) is an important herbal tea in the diet of the ‘Yi’ people, an ethnic group in China, and it has shown significant antioxidant, anti-inflammatory, and hepatoprotective effects in vitro. This study aims to explore the protective effects of the aqueous-ethanol extract (QE) taken from QT against ᴅ-galactose (ᴅ-gal)-induced oxidative stress damage in mice and its potential mechanisms. QE was identified as UHPLC-HRMS/MS for its chemical composition and possible bioactive substances. Thus, QE is rich in phenolic and flavonoid compounds. Twelve compounds were identified, the main components of which were chlorogenic acid, quinic acid, and 6′-O-caffeoylarbutin. Histopathological and biochemical analysis revealed that QE significantly alleviated brain, liver, and kidney damage in ᴅ-gal-treated mice. Moreover, QE remarkably attenuated oxidative stress by activating the Nrf2/HO-1 pathway to increase the expression of antioxidant indexes, including GSH, GSH-Px, CAT, SOD, and T-AOC. In addition, QE administration could inhibit the IL-1β and IL-6 levels, which suppress the inflammatory response. QE could noticeably alleviate apoptosis by inhibiting the expressions of Caspase-3 and Bax proteins in the brains, livers, and kidneys of mice. The anti-apoptosis mechanism may be related to the upregulation of the SIRT1 protein and the downregulation of the p53 protein induced by QE in the brain, liver, and kidney tissues of mice. Molecular docking analysis demonstrated that the main components of QE, 6′-O-caffeoylarbutin, chlorogenic acid, quinic acid, and robustaside A, had good binding ability with Nrf2 and SIRT1 proteins. The present study indicated that QE could alleviate ᴅ-gal-induced brain, liver and kidney damage in mice by inhibiting the oxidative stress and cell apoptosis; additionally, the potential mechanism may be associated with the SIRT1/Nrf2 signaling pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway

Wang,

Zhao

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

The Comparative Effects Between Long‐Term and Short‐Term Treatment of Finasteride on Anxiety‐Like and Depression‐Like Behaviors in Early Senescent Male Rats

Pintana,

Apaijai,

Chunchai

et al. 2024

J of Neuroscience Research

View full text Add to dashboard Cite

This study aims to compare the efficacy of 5‐alpha‐reductase inhibitors (5ARIs) on anxiety and depression between long‐term and short‐term treatment followed by withdrawal in d‐galactose (Dgal)–induced senescent male rats. Thirty‐two, 8‐week‐old, male Wistar rats were divided into two groups: control rats and Dgal‐treated rats (150 mg/kg/day; subcutaneously) for 18 weeks. At week 13, Dgal‐treated rats were subdivided into three subgroups: (1) vehicle (DgV), (2) long‐term treatment with 5ARIs, Finasteride 5 mg/kg/day, per oral for 6 weeks (DgF), (3) short‐term treatment with 5ARIs, Finasteride 5 mg/kg/day, per oral for 2 weeks followed by a 4‐week withdrawal period (DgW). Anxiety and depression were assessed using the elevated‐plus maze (EPM) and splash test (ST). Blood was collected for biochemical analysis. After euthanasia, the brains were removed to examine brain inflammation, oxidative stress, neuroactive steroids, brain metabolites, and brain senescent markers. We found that DgV rats exhibited metabolic disturbance with a reduced preference index of the EPM, and grooming duration in ST. Increased brain neurotoxic metabolites, along with increased brain inflammation/oxidative stress, and reduced microglia complexity were observed in the DgV rats. Both therapeutic approaches improved metabolic parameters and preference index in the open arm of EPM in Dgal‐treated rats, while grooming duration and microglia complexity were increased only in DgF rats. Our results indicate that Fin reduces depression‐like and anxiety‐like behaviors by reducing brain inflammation, oxidative stress, and brain senescent. In conclusion, long‐term treatment with 5ARIs is more effective in alleviating depression than short‐term treatment followed by withdrawal in Dgal‐induced early senescent male rats.

show abstract

Recent trends in ginseng research

Ito,

Ito

2024

J Nat Med

View full text Add to dashboard Cite

AFG, an important maillard reaction product in red ginseng, alleviates D-galactose-induced brain aging in mice via correcting mitochondrial dysfunction induced by ROS accumulation

Cited by 8 publications

References 35 publications

Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway

Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway

The Comparative Effects Between Long‐Term and Short‐Term Treatment of Finasteride on Anxiety‐Like and Depression‐Like Behaviors in Early Senescent Male Rats

Recent trends in ginseng research

Contact Info

Product

Resources

About