Aflapin<sup>®</sup>: A novel and selective 5-lipoxygenase inhibitor for arthritis management

Suva, Manoj A; Kheni, Dharmesh B; Sureja, Varun P

doi:10.4103/ijpn.ijpn_71_17

Cited by 14 publications

(14 citation statements)

References 5 publications

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“…B. serrata extract–derived boswellic acids are specific, non-redox inhibitors of 5-LOX, and 3- O -acetyl-11-keto-β-boswellic acid (AKBA) possesses the most potent 5-LOX inhibitory activity. [ 23 ] In a 90-day, double-blind, randomized, placebo-controlled study B. serrata extract was evaluated for its efficacy and safety in the treatment of osteoarthritis of the knee. The extract at 100 and 250 mg daily dose conferred clinically and statistically significant improvements in pain scores and physical function scores in osteoarthritis patients.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen

2020

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Background: Acetaminophen (paracetamol) is one of the most commonly used over-the-counter for pain relief. Management of acute pain with plant-based nutrients has remained suboptimal due to an absence of data supporting acute relief of pain. In the present study, it was hypothesized that high-dissolution liquid treatment of black sesame extract oil, Curcuma longa and Boswellia serrata may provide pain relief in people with acute musculoskeletal pain as quickly as acetaminophen. Methods: In this randomized active controlled open label study, 88 healthy subjects with acute musculoskeletal pain were randomized to receive treatment capsule (Rhuleave-K; 1,000 mg/d) or 1,000 mg/d acetaminophen for 7 days. Change in pain intensity and pain relief at first 6 hours, 3 days, and 7 days were measured. The onset of analgesia was measured by perceptible pain relief and meaningful pain relief. Other measures were McGill Pain Questionnaire and Patient Global Impression Change. Results: The treatment formulation resulted in average magnitude of pain relief comparable to the acetaminophen. Sixty-six percent of subjects in the treatment group reported positive response in pain relief (≥50% max TOTPAR; total pain relief) after 6 hours, compared to 73% of control. Seventy-three percent of subjects on treatment were considered positive responders, compared to 80% in the control group. The average time of onset of analgesia was 1 hour for the treatment group, versus 0.83 hour for control. At the end of day 3 and 7, there was significant improvement ( P < .001 for day 3 and day 7) in the pain condition of treatment group and was comparable to control ( P = .436 for day 3 and P = .529 for day 7). The total McGill Pain score showed significant reduction in pain with the treatment irrespective of the pain intensity statistically equal ( P = .468) to control. Both the groups were equal in providing sensory pain relief ( P = .942), but the treatment was 8.57 times significantly better ( P = .027) than acetaminophen in reducing the unpleasantness and emotional aspects (affective domain) involved with acute pain. Conclusion: The results showed that the treatment used in the study may act as a natural, fast acting, and safe alternative for acute pain relief comparable to acetaminophen.

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Section: Discussionmentioning

confidence: 99%

Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen

2020

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“…This study demonstrated that Aflapin significantly alleviates pain and improves joint function beginning at day 5 of treatment. 42 In another double blinded, placebo controlled study, 60 patients suffering with moderate to mild osteoarthritis were recruited and randomized to Aflapin group 100mg/day (n=20), 5-Loxin group 100 mg/day (n=20), and placebo (n=20). The patients were evaluated for pain, physical function and stiffness using WOMAC index, LFI score, VAS scale on day 0 baseline, day 7, day 30, day 60, day 90 respectively.…”

Section: Clinical Evidence Of Aflapin In Osteoarthritismentioning

confidence: 99%

Role of undenatured collagen type II and Aflapin combination in the management of osteoarthritis: a review

Jain¹,

Mehra

Mehta

et al. 2021

Int J Res Orthop

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<p class="abstract">Osteoarthritis (OA) is the most common joint disease affecting millions worldwide. Osteoarthritis typically affects the knees, hands, hips, and feet. It is characterized by complex pathologic changes in cartilage which haven’t been fully elucidated yet. However, recent research has shown the involvement of two contributing pathways namely the mechanical and the immune pathways which interlink to cause cartilage destruction. Patients with OA on current treatment options still inevitably progress to a more severe stage becoming candidates for total joint replacement. The cornerstones of OA management in the early stage include exercises, weight loss, education—complemented by topical or oral nonsteroidal anti-inflammatory drugs (NSAIDs) and nutraceuticals like Undenatured type II collagen and Aflapin. Both Undenatured type II collagen and Aflapin offer great promise in OA management by targeting both the immune and mechanical pathways respectively. Undenatured type II collagen works by oral tolerization turning off the immune response in the inflammatory damage (T cell response) against endogenous Type II collagen in the cartilage thus reducing joint inflammation and degradation and stimulates anti-inflammatory cytokine release. Aflapin inhibits 5-LOX and exerts anti-inflammatory action thus providing symptomatic relief of pain and inflammation. This review focusses on the role of mechanical and immune pathways in the pathogenesis of OA and the impact of the combination of Undenatured type-II collagen and Aflapin in targeting these pathways thus improving the clinical outcomes.</p>

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“…3-O-acetyl-11-keto-beta-boswellic acid (AKBA), the active ingredient of BSE is a powerful inhibitor of 5-lipoxygenase (5-LOX) activity (Suva et al, 2017) which can reduce pain and inflammation associated with OA (Suva et al, 2018).…”

Section: Reviewmentioning

confidence: 99%

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Ong¹,

Sakinah²,

Shahril³

et al. 2019

Food Res.

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The increasing number of evidence has reported inflammation and oxidative stress as key mediators of osteoarthritis (OA) joint pathology. Therefore, the usage of dietary supplements targeting inflammation and oxidative stress in OA may emerge as a rewarding therapeutic strategy. This study aimed to explore the efficacy of antioxidant and anti-inflammatory dietary supplements used to manage OA. A methodological framework proposed by Arksey and O’Malley was used to conduct this scoping review. An electronic database search of English academic articles was conducted using PubMed, MEDLINE and ScienceDirect from 2000 to 2018. Randomized controlled trials (RCTs) of OA with parallel groups by comparing dietary supplements with placebo consumption were eligible for inclusion. Out of 69,150 studies identified, a total of 41 studies were included, with 25 antioxidant or anti-inflammatory dietary supplements identified. There were 3325 respondents (1740 in the treatment group and 1585 in the placebo group), all aged ≥ 25 years old and comprised of 69.6% and 30.4% female and male respondents, respectively. The majority of the studies recruited participants with knee OA (n = 33) with a follow-up duration of 3 to 32 weeks. Overall, most of the dietary supplements (n =17) demonstrated a beneficial effect on the clinical signs and symptoms, such as Boswellia serrata extract (BSE), Pycnogenol and L-carnitine. In contrast, Aquamin supplementation did not exert positive impacts on OA management, while inconsistent findings were observed in greenlipped mussel (GLM) extract, vitamin E, methylsulfonylmethane (MSM), licorice flavonoid oil (LFO), ginger, willow bark extract and rose hip supplementation. In summary, the role of anti-inflammatory and antioxidant dietary supplements cannot be ignored as they can offer alleviated pain and symptom relief.

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Aflapin^®: A novel and selective 5-lipoxygenase inhibitor for arthritis management

Cited by 14 publications

References 5 publications

Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen

Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen

Role of undenatured collagen type II and Aflapin combination in the management of osteoarthritis: a review

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

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Aflapin®: A novel and selective 5-lipoxygenase inhibitor for arthritis management

Cited by 14 publications

References 5 publications

Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen

Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen

Role of undenatured collagen type II and Aflapin combination in the management of osteoarthritis: a review

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

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Product

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Aflapin^®: A novel and selective 5-lipoxygenase inhibitor for arthritis management