Aflatoxin M1 and ochratoxin A in baby formulae in Turkey: Occurrence and safety evaluation

Kabak, Bülent

doi:10.1016/j.foodcont.2012.01.032

Cited by 53 publications

(32 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is known that climatic conditions, i.e., high temperature and humidity in tropical and subtropical regions favor the growth of toxigenic Aspergillus fungi (Kabak, 2012). Also, long periods of high temperatures 345 and long-lasting drought in summer in other regions can also promote the development of particular mycotoxins (Bilandzic et al, 2014;Manouras and Malissiova, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Feed contaminated with AF may cause a doserelated decrease in feed intake and reduced weight gain, liver damage, alterations of the immune response (immunosuppression) and eventually significant economic losses in swine production (Bryden, 2012;Marin et al,2002;Weaver et al, 2013a). However, under field conditions, mycotoxins usually occur in concentrations leading to reduced animal performance and variable immunosuppression without causing any obvious clinical symptoms (Kabak, 2012;ProdanovRadulovic et al, 2014). It is especially important to point out that impairment of immune functions might culminate in decrease of host resistance to infections and possibly compromise vaccine-induced immunity even in properly vaccinated animals (Marin et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…ycotoxins are toxic secondary metabolites produced by certain fungi belonging predominantly to the Aspergillus, Penicillium and Fusarium genera, and may cause a variety of adverse effects on both humans and animals (Kabak, 2012). Depending on classification, 300-400 mycotoxins are known today (Streit et al, 2012).…”

mentioning

confidence: 99%

“…Among them, aflatoxins (AFs) are the most abundant and toxic metabolites produced primarily by two closely related Aspergillus moulds, A. flavus and A. parasiticus (Marin et al, 2002) and in rare cases, by A. nomius (Ertas et al, 2011). There are at least 20 different types of naturally-occurring AFs and the most recognized are B1, B2, G1 and G2 (Diekman and Green, 1992;Kabak, 2012). Animals are exposed to AFs mainly through the consumption of contaminated feed, particularly products of plant origin such as cereal grains (Hussein and Brasel, 2001;Weaver et al, 2013a;Manouras and Malissiova, 2015).…”

mentioning

confidence: 99%

“…(Duarte et al, 2013). Depending on the level of feed contamination, approximately 0.3-6.3% of AFB1 ingested by livestock is transformed to AFM1 in milk (Prandini et al, 2008;Kabak, 2012). The AM1 has been detected in the milk of cows, sheep, goats, buffalos, camels and women (Galvano et al, 1996;Duarte et al, 2013;Bilandzic et al, 2014).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Aflatoxin M1 levels in sow milk

Prodanov-Radulović

Baloš

Jakšić

et al. 2018

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

ABSTRACT. Aflatoxins (AFs) are one of the most known and investigated group of mycotoxins, which can be found as contaminants in different types of food and feed. Animals are exposed to AFs mainly through the consumption of contaminated feed, particularly products of plant origin. Among AFs, aflatoxin M1 (AFM1) is the monohydroxylated derivative of AFB1 formed in the liver and excreted into the milk of lactating animals. This study encompassed the Vojvodina region of Serbia and was aimed at determining the levels of AFM1 excretion in sows' milk in the first 3-5 days of lactation, after consumption of naturally contaminated with AFB1 maize. A total of 110 sows' milk samples from 11 swine farms in the specific region were analyzed by Enzyme Linked Immunosorbent Assay (ELISA). Different levels of AFM1 were detected in the majority (97%) of the examined milk samples. The obtained results showed AFM1 levels ranging from 5 to 165.4 ng/L. The results of this study pose special health concern associated with aflatoxin contamination of swine feed raw materials in this particular part of Serbia. Moreover, such high incidence of AFM1 detection in sows' milk may suggest the occurrence of long-term low level aflatoxicosis clinical cases.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Aflatoxin M1 levels in sow milk

Prodanov-Radulović

Baloš

Jakšić

et al. 2018

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

show abstract

Incidences of Mould and Bacterial Toxins in Dairy Products

Wan¹,

Shah²,

El-Nezami³

2016

Microbial Toxins in Dairy Products

View full text Add to dashboard Cite

Characterization of oligosorbents and application to the purification of ochratoxin A from wheat extracts

Ali

Pichon

2013

Anal Bioanal Chem

View full text Add to dashboard Cite

The aim of this work was to optimize the preparation of an anti-ochratoxin A (OTA) oligosorbent (OS), a solid-phase extraction sorbent based on OTA aptamers covalently immobilized on sepharose. Different syntheses were carried out by modifying the side of the oligonucleotide chain bound to the sepharose, the length of the spacer arm between the aptamer and the sepharose and the amount of the aptamers introduced during the covalent grafting. Indeed, the capacity of OSs prepared using 3'- or 5'-amino-modified sequences with a C6 or a C12 was studied. In the best conditions, the concentration of aptamers sequence used during their grafting was increased and a capacity close to 40 nmol g(-1) of OS was reached. The potential of the resulting OSs was also studied in pure media. For this, their selectivity was checked by comparing them to a control sorbent prepared without immobilizing aptamers. Extraction recoveries close to 100% were obtained on all OSs, while no retention was observed on the control sorbent. OS does not demonstrate any cross-reactivity towards OTA metabolites, i.e., ochratoxin B and ochratoxin hydroquinone. The oligosorbent was finally applied to the clean-up of OTA from wheat sample extracts. Extraction recoveries were not affected by matrix interferences and the resulting chromatogram clearly highlights the selectivity of the sorbent that allows the removal of matrix components thus improving the reliability of the quantitation of OTA in real samples.

show abstract

Aflatoxin M1 and ochratoxin A in baby formulae in Turkey: Occurrence and safety evaluation

Cited by 53 publications

References 12 publications

Aflatoxin M1 levels in sow milk

Aflatoxin M1 levels in sow milk

Incidences of Mould and Bacterial Toxins in Dairy Products

Characterization of oligosorbents and application to the purification of ochratoxin A from wheat extracts

Contact Info

Product

Resources

About