Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs

Beugnet, Frédéric; deVos, Christa; Liebenberg, Julian; Halos, Lénaïg; Fourie, Josephus J.

doi:10.1051/parasite/2014045

Cited by 20 publications

(16 citation statements)

References 20 publications

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“…Two isoxazoline compounds, afoxolaner (monthly doses) and fluralaner (single dose), administered orally provided 100% efficacy for 90 days [ 363 ]. Dogs treated with afoxolaner 1 day prior to infestation killed 100% of the fleas within 6 h [ 361 ]. Afoxolaner on dogs provided >95% kill within 8 h [ 393 ].…”

Section: Pest Managementmentioning

confidence: 99%

The Biology and Ecology of Cat Fleas and Advancements in Their Pest Management: A Review

Rust

2017

Insects

114

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The cat flea Ctenocephalides felis felis (Bouché) is the most important ectoparasite of domestic cats and dogs worldwide. It has been two decades since the last comprehensive review concerning the biology and ecology of C. f. felis and its management. Since then there have been major advances in our understanding of the diseases associated with C. f. felis and their implications for humans and their pets. Two rickettsial diseases, flea-borne spotted fever and murine typhus, have been identified in domestic animal populations and cat fleas. Cat fleas are the primary vector of Bartonella henselae (cat scratch fever) with the spread of the bacteria when flea feces are scratched in to bites or wounds. Flea allergic dermatitis (FAD) common in dogs and cats has been successfully treated and tapeworm infestations prevented with a number of new products being used to control fleas. There has been a continuous development of new products with novel chemistries that have focused on increased convenience and the control of fleas and other arthropod ectoparasites. The possibility of feral animals serving as potential reservoirs for flea infestations has taken on additional importance because of the lack of effective environmental controls in recent years. Physiological insecticide resistance in C. f. felis continues to be of concern, especially because pyrethroid resistance now appears to be more widespread. In spite of their broad use since 1994, there is little evidence that resistance has developed to many of the on-animal or oral treatments such as fipronil, imidacloprid or lufenuron. Reports of the perceived lack of performance of some of the new on-animal therapies have been attributed to compliance issues and their misuse. Consequentially, there is a continuing need for consumer awareness of products registered for cats and dogs and their safety.

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Section: Pest Managementmentioning

confidence: 99%

The Biology and Ecology of Cat Fleas and Advancements in Their Pest Management: A Review

Rust

2017

Insects

114

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“…The ectoparasitic activity of the novel isoxazoline chemotype was evaluated in as eries of studies againstp rominentf lea and tick species, such as C. felis, D. variablis,a nd R. microplus,a s well as other pests including an assortment of flies and mosquitoes. [27,34,51,52] Identification, cloning, and functional expression of GABA-and glutamate-receptor genes of R. microplus in addition to thee xpression of dlr and susceptible C. felis and D. melanogaster GABA receptors have sparkedt he development of on-target assays, and ac omprehensive exploration of the chloride channel inhibiting qualities relative to relevant representative parasiticides ensued. [34] Accordingly,aplethora of studies verify the superiority of the new chemotype,emphasizing the advanced potency over fipronil, dieldrin, and other GABACl antagonists in arthropods.…”

Section: Selectivity and Safety Profilementioning

confidence: 99%

Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites

Weber

Selzer

2016

ChemMedChem

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Efficient control of arthropod ectoparasite infestations has a long-standing history in the agriculture and veterinary sectors, aiming to decrease the parasite burden of affected crops and animals. Ligand-gated chloride channels (LGCCs) modulated by γ-aminobutyric acid (GABA) and glutamate have been identified as suitable molecular targets, and several classes of potent parasiticides have been devised. Due to the increase in cross-resistance and decreased development of new chemical entities, an urgent need for new parasiticides or prevention schemes has emerged. In the last decade, an innovative isoxazoline chemotype appears to offer promise for inhibiting LGCCs with a new mode of action and distinct binding site from that of historical agents. Considerable efforts have focused on optimizing the antiparasitic activity of isoxazolines and may provide the potential for future human use.

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“…Recently, a new orally administered afoxolaner chewable product was introduced into the flea and tick control market [ 8 – 11 ]. Afoxolaner is a member of the isoxazoline class of compounds and is labeled for the treatment and prevention of flea infestations and treatment and control of ticks on dogs.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of afoxolaner chewables to control flea populations in naturally infested dogs in private residences in Tampa FL, USA

et al. 2015

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BackgroundA study was conducted to evaluate the effectiveness of afoxolaner chewables to control flea populations in naturally infested dogs in private residences in Tampa FL, USA. Evaluations of on-animal and premises flea burdens, flea sex structure and fed-unfed premises flea populations were conducted to more accurately assess flea population dynamics in households.MethodsThirty seven naturally flea infested dogs in 23 homes in Tampa, FL were enrolled in the study and treated with afoxolaner chewables. Chewables (NexGard® Chewables; Merial) were administered according to label directions by study investigators on study day 0 and once again between study days 28 and 30. Flea infestations on pets were assessed using visual area thumb counts and premises flea infestations were assessed using intermittent-light flea traps on days 0, 7, 14, 21, and once between study days 28–30, 40–45, and 54–60.ResultsWithin 7 days of administration of afoxolaner chewable tablets, flea counts on dogs were reduced by 99.3 %. By one month post-treatment, total flea counts on dogs were reduced by 99.9 %, with 97.3 % (36/37) of the dogs being flea free. Following the second dosing on study day 28–30, total on-dog flea burden was reduced by 100 % on days 40–45 and 54–60. On day 0, the traps collected a geometric mean of 18.2 fleas. Subsequent reductions in emerging flea populations were 97.7 and 100 % by days 28–30 and 54–60, respectively. There were 515 total fleas (Ctenocephalides felis felis) collected in the intermittent light flea traps on day 0, and 40.4 % of those fleas displayed visual evidence of having fed. Seven days after initial treatment, only 13.1 % of the fleas contained blood and by day 14 only 4.9 % of the fleas collected in traps displayed evidence of having fed. On day 0, prior to treatment, 60 % of the unfed fleas collected in intermittent-light flea traps were females, but by days 28–30, unfed males accounted for 78 % of the population.ConclusionsThis in-home investigation conducted during the summer of 2014 in subtropical Tampa, FL demonstrated that afoxolaner chewables rapidly and effectively eliminated flea populations in infested dogs and homes.

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Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs

Cited by 20 publications

References 20 publications

The Biology and Ecology of Cat Fleas and Advancements in Their Pest Management: A Review

The Biology and Ecology of Cat Fleas and Advancements in Their Pest Management: A Review

Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites

Evaluation of afoxolaner chewables to control flea populations in naturally infested dogs in private residences in Tampa FL, USA

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