African Herbal Medicines: Adverse Effects and Cytotoxic Potentials with Different Therapeutic Applications

Okaiyeto, Kunle; Oguntibeju, Oluwafemi Omoniyi

doi:10.3390/ijerph18115988

Cited by 92 publications

(46 citation statements)

References 163 publications

(118 reference statements)

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“…THs of the study area know the effect of overdose use of some TMPs on the health of patients. This study result is different from the report of most communities of Africa [ 58 ] that indicates no regulated use and adverse effect [ 59 ]. They provide differential usage information and prescription to their patients and determine the dosage supporting different conditions, status of patients, and nature of the ailment with precautions.…”

Section: Discussioncontrasting

confidence: 99%

Ethnobotany of traditional medicinal plants and associated indigenous knowledge in Dawuro Zone of Southwestern Ethiopia

Agize

Asfaw

Nemomissa

et al. 2022

J Ethnobiology Ethnomedicine

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Background The study aimed at documenting the indigenous and local knowledge and use of traditional medicinal plants for treating human and livestock ailments in Dawuro Zone of Ethiopia. Methods A survey was conducted among traditional healers and native administrators through discussion, interviews, and field observations. The snowball sampling technique was used to select 384 traditional healers in purposefully selected 50 villages spanning seven districts for face-to-face individual interviews. The chi-square test was applied to establish associations between traditional healers’ demographics, the distance between the village site and the nearest natural forest and a health center, and SPSS V.20 software was used for the analysis. Results The traditional healers of the study area reported the use of 274 traditional medicinal plant species belonging to 217 genera and 82 families. Asteraceae (11.68%), Fabaceae (9.49%), and Lamiaceae (9.12%) were the foremost frequently used families. Herb species (54.8%) and leaves (65%) were predominantly sourced from the wild environment. The quantity of medicinal plants used (x2 = 278.368, df = 20, P = 0.000) and years of (experience in) traditional healing using herbs (x2 = 76.358, df = 10, P = 0.000) varied with distance from the natural forests. The service charge for healing had strong positive association (x2 = 24.349, df = 5, P = 0.000) with healer’s age (x2 = 309.119, df = 184, P = 0.000) and educational level (x2 = 851.230, df = 598, P = 0.000) with distance of traditional healer's residence from the medical institution. The agricultural activities, urbanization, low or no charge for the healing service, the secrecy and oral transfer of the knowledge, and the demand for medicinal and other multiple purposes species were some of the factors threatening the resource and the associated knowledge as well as the service in the study area. Conclusion There are diversified traditional medicinal plants applied for healthcare of the community and domestic animals of the study area. The source of remedies mostly depends on herbs of natural forests, and the leaf was the most frequently used plant part. Developing conservation intervention and sustainable systems of utilization is needed for multipurpose medicinal plants. Finally, integrating with modern system and formalizing, legalizing, and capacitating the traditional medicine practitioners are needed for access of primary healthcare systems to rural communities.

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Section: Discussioncontrasting

confidence: 99%

Ethnobotany of traditional medicinal plants and associated indigenous knowledge in Dawuro Zone of Southwestern Ethiopia

Agize

Asfaw

Nemomissa

et al. 2022

J Ethnobiology Ethnomedicine

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“…These phytochemicals possess different pharmacological potentials; however, they could be toxic at a high concentration [132]. The toxicology study of several plants with significant therapeutic potentials has been reported in the literature [133]. Likewise, some researchers have investigated the toxicity of the solvent extracts of C. volubile to ascertain its safety.…”

Section: Safety Concerns Regarding the Use Of The Plant (Toxicity Studies)mentioning

confidence: 99%

Traditional Uses, Nutritional and Pharmacological Potentials of Clerodendrum volubile

Okaiyeto

Falade

Oguntibeju

2021

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Clerodendrum volubile is an underutilized leafy vegetable consumed in some parts of Nigeria. The interest in C. volubile has continued to increase due to its multipurpose values, including traditional uses, nutritional properties, and some therapeutic potentials; however, the pharmacological prospects of the plant are yet to be fully explored. Therefore, in the present review, different databases such as PubMed, Scopus, Web of Science, Google Scholar, etc. were explored to retrieve publications used to write this review. The pharmacological potentials of C. volubile, such as anticancer, antioxidant, antiviral, antimicrobial, anti-inflammatory, hepatoprotective, antidiabetic, and anti-hypertensive properties, were highlighted. The toxicological potential of the plant is also discussed. Proposed mechanisms that underline its biological activities include modulation of redox homeostasis, leading to decreased oxidative stress; down-regulation of matrix metalloproteinase-9 (MMP-9) expression; inhibition of key enzymes implicated in diabetes mellitus, hypertension, and neurological diseases; and inhibition of oxidative burst and inflammatory cytokines. Furthermore, the prospect of endophytes from C. volubile as a bioresource to produce novel therapeutic agents, as well as the development of nanotherapeutics from the plant extracts and its phytoconstituents, are discussed. In conclusion, C. volubile possesses an enormous number of possible pharmacological properties and therapeutic potentials waiting to be explored.

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“…Another key concern is that the increased use of herbal medicines has been accompanied by their adulteration, which includes increased use of synthetic compounds to increase profit levels; however, this leads to concerns with quality control unless proactively addressed ( Ekar and Kreft, 2019 ; Enioutina et al, 2020 ; Kum et al, 2021 ; Okaiyeto and Oguntibeju, 2021 ). Alongside this, there have also been an increase in the extent of falsified medicines, including herbal medicines, for both life style and health-related conditions across countries ( BottomLineInc, 2014 ; Newsmax_Fake_2015 ; Nuryunarsih, 2016 ; Ekar and Kreft, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Tool to Improve Community Pharmacists’ Surveillance Role in the Safe Dispensing of Herbal Supplements

Jairoun

Al‐Hemyari²,

Abdulla³

et al. 2022

Front. Pharmacol.

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Background: There has been an appreciable increase in the use of herbal supplements, including immune boosters, during the current COVID-19 pandemic. However, there are concerns with falsified herbal supplements.Objectives: Developed a new questionnaire that can potentially help community pharmacists identify the extent of falsified herbal supplements.Methods: A 9-month cross sectional study was conducted among 500 community pharmacies across United Arab Emirates. A new 5-factor, 24-itmes scale was developed based on current labelling requirements across countries and piloted. This included seven items on identified uses and contraindication, seven items on hazard identification, four items on product identity, three items on packaging and product insert and three items on product handling and storage. The face and content validity of the scale was assessed via the content validity index (CVI). Its construct validity was tested using an exploratory factor analysis (EFA) via principally component analysis (PCA). The model was subsequently confirmed through partial confirmatory factor analysis (PCFA). Its reliability was assessed via test-retest reliability, internal consistency, item internal consistency (IIC), and intraclass correlation coefficients (ICCs).Results: The CVI of the finalized questionnaire was 0.843. The Kaiser-Meyer-Olkin measure of sampling adequacy was 0.891, and Bartlett’s test of sphericity indicated significance (p-value < 0.001). Confirmation of the subsequent 5-domains was achieved through PCFA using maximum likelihood analysis with oblimin rotation. The PCFA obtained values was 0.962 for NFI, 0.977 for CFI, and 0.987 for the Tucker Lewis Index. All values were greater than 0.95, and the RMSEA value was 0.03 (i.e., less than 0.06). Consequently, the model had a good fit. All domains demonstrated Cronbach’s alpha coefficients above 0.70, with 0.940 for the full instrument. Meanwhile, all items met the IIC correlation standard of ≥0.40. The instrument presented good ICC statistics of 0.940 (0.928–0.950) as well as statistical significance (p < 0.001). Community pharmacists with more than 10 experience years were more likely to identify falsified herbal supplements compared to those with 1–10 years experience (p < 0.001).Conclusion: This study developed and validated a new instrument to identify safe herbal supplements, which should enhance the role of the community pharmacists in the safe and effective treatment of suitable patients with herbal supplements.

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African Herbal Medicines: Adverse Effects and Cytotoxic Potentials with Different Therapeutic Applications

Cited by 92 publications

References 163 publications

Ethnobotany of traditional medicinal plants and associated indigenous knowledge in Dawuro Zone of Southwestern Ethiopia

Ethnobotany of traditional medicinal plants and associated indigenous knowledge in Dawuro Zone of Southwestern Ethiopia

Traditional Uses, Nutritional and Pharmacological Potentials of Clerodendrum volubile

Development and Validation of a Tool to Improve Community Pharmacists’ Surveillance Role in the Safe Dispensing of Herbal Supplements

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