African Tick-Bite Fever

Fralish, Matthew S.; Mangalindan, Kristin E.; Farris, Christina M.; Jiang, Ju; Green, Margaret C.; Blaylock, Jason M

doi:10.1016/j.amjmed.2020.03.031

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…New and increasingly common infectious diseases of global concern caused by the group of bacteria of the genus Rickettsia are defined as spotted fevers. Most spotted fevers, which include Rocky Mountain spotted fever, Mediterranean spotted fever, Typhus group and Q fever, resolve after treatment with doxycycline for at least 10 days [ 74 ].…”

Section: Bacteriostatic Activitymentioning

confidence: 99%

Tetracyclines—An Important Therapeutic Tool for Dermatologists

Orylska-Ratynska

Placek

Owczarczyk‐Saczonek

2022

IJERPH

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Tetracyclines are a group of antibiotics whose first representative was discovered over 70 years ago. Since then, they have been of great interest in dermatology. In addition to their antibacterial activity, they are able to inhibit metalloproteinases and exhibit anti-inflammatory, anti-apoptotic and antioxidant effects. The side effects have been thoroughly studied over the years, the most characteristic and important ones in daily dermatological practice being: phototoxicity, hyperpigmentation, onycholysis, photoonycholysis, induced lupus erythematosus, and idiopathic intracranial hypertension. In this article, we summarize the use of tetracyclines in infectious diseases and inflammatory dermatoses, and further discuss the instances where the efficacy and safety of tetracyclines have been highlighted over the past few years.

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Section: Bacteriostatic Activitymentioning

confidence: 99%

Tetracyclines—An Important Therapeutic Tool for Dermatologists

Orylska-Ratynska

Placek

Owczarczyk‐Saczonek

2022

IJERPH

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“…We analyzed hematologic and biochemical laboratory data (Table 3). From all reported cases, excluding missing information of some variables ("no data"), 70.7% presented with abnormal laboratory findings, of which 47.2% had elevated aspartate aminotransferase (AST), 47.2% elevated nine, antiphospholipid antibodies, ferritin, total bilirubin, lymphopenia, leukocytosis, and monocytosis [15,17,19,22,25,28,29,45,52,56]. Two cases (3.8%) were described as having "increased hepatic enzymes" not otherwise specified [39].…”

Section: Laboratory Manifestationsmentioning

confidence: 99%

Clinical, epidemiological, and laboratory features of Rickettsia africae infection, African tick-bite fever: A systematic review

Silva-Ramos

Faccini-Martínez

2021

Infez Med

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African tick-bite fever (ATBF), caused by Rickettsia africae, is the main tick-borne rickettsiosis and the second most frequent cause of fever after malaria in travelers returning from sub-Saharan Africa. General descriptions on ATBF were made in the first two decades after recognized as a new infectious entity, and since then, many authors have contributed to the knowledge of the disease by reporting clinical cases in scientific literature. We developed a systematic review that evaluated all available evidence in the literature regarding clinical, epidemiological, and laboratory features of confirmed R. africae rickettsiosis cases. We followed the recommendations made by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guide. A total of 48 scientific publications (108 confirmed cases) were analyzed in order to extract data for developing this review. Overall, our results show that R. africae rickettsiosis is more frequent in males in the age group of 18-64 years, more than 80% of the SUMMARY cases occurred in European travelers, South Africa was the country where most infections were acquired, and almost 40% of cases occurred in clusters. Clinically, more than 80% of the cases had fever and eschar (55% developed multiple eschars), rash was present in less than the half of cases, and lymphangitis was not a common sign (11%). Headache, myalgia and regional lymphadenopathy were predominant nonspecific clinical manifestation (mean of 60%, 49% and 51%, respectively). Our results show that at least 70% of R. africae cases had altered laboratory parameters, most often showing an increase in transaminases and C-reactive protein. Tetracycline-class antibiotics, as monotherapy, were used in most (>90%) of the patients. Overall, only 4% of cases had complications, 12% required hospitalization, and there was a 100% rate of clinical recovery.

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African Tick-Bite Fever

Cited by 2 publications

References 8 publications

Tetracyclines—An Important Therapeutic Tool for Dermatologists

Tetracyclines—An Important Therapeutic Tool for Dermatologists

Clinical, epidemiological, and laboratory features of Rickettsia africae infection, African tick-bite fever: A systematic review

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