Ag-substituted octacalcium phosphate blocks that exhibit high osteoconductivity and high antibacterial activity toward various pathogens

Interlayer expansion of octacalcium phosphate via forced oxidation of the intercalated molecules within its interlayers

“…When the dicarboxylic-substituted OCP was immersed in basic Na-containing solutions, a Ca ion exchange with Na was observed at the P 5 PO 4 conjugated site (at the root of the hydrous layer). 27 The hydrous layer was partly reconstructed. Since the NaClO solution is a basic Na solution, a similar reaction could occur.…”

“…17–26 Based on these mechanisms, new combinations of drug biomaterials were fabricated using OCP units as drug capsules. 17,27,28…”

Fabrication of interconnected porous Ag substituted octacalcium phosphate blocks based on a dissolution-precipitation reaction

“…The Ag content decreased with the increase in the granule sizes. Note, the Ag contents in the treated samples were sufficient for exhibiting contact antibacterial ability (>0.05 at%) in OCP [ 24 ]. Based on the XRD and elemental analysis results obtained for the treated samples, the acidic calcium phosphate foam after immersion were called as OCP-Ag foam.…”

“…Based on our evaluation, taking advantage of the low symmetrical crystal structure ( P -1) in OCP enables the doping of various elements and molecules into OCP crystal structures [ 18 – 22 ]. Recently, we doped silver (Ag) into an OCP crystal structure as replacing Ca in the conjugated site of P 5 PO 4 (OCP-Ag) powders and blocks [ 23 , 24 ]. The OCP-Ag exhibited both excellent contact antibacterial ability and low cytotoxicity for osteoblast.…”

Preparation of a Bi6O5(OH)3(NO3)5·2H2O/AgBr composite and its long-lasting antibacterial efficacy

“…4–8 Non-drug antibacterial nanomaterials have attracted increasing attention because of their promising antibacterial and antimicrobial capacities, for example, Ag, Au, and TiO 2 nanoparticles (NPs). 9–11 Some non-drug nanomaterials have exhibited effective long-lasting antibacterial performance and potential value in clinical treatments, for example, Cu/Ti–6Al–4V, Cu/GO, and polylactic acid (PLLA)/Ag. 8,12,13 In 2020, Liu et al successfully synthesized the “inside–outside” Ag-NPs-loaded composite fibers, and Ag-NPs were uniformly distributed on the inner surface of the PLLA fibers.…”