AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review

Shah, Shailja C.; Piazuelo, M. Blanca; Kuipers, Ernst J.; Li, Dan

doi:10.1053/j.gastro.2021.06.078

Cited by 234 publications

(194 citation statements)

References 93 publications

(102 reference statements)

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“…In addition, an increased risk of gastric cancer is noted among individuals with incomplete (colonic, type III) and/or widespread intestinal metaplasia of the mucous membrane [50,51]. The modified OLGIM system (Operative Link on Gastric Intestinal Metaplasia Assessment), being more reproducible, offers only an assessment of the intestinal metaplasia presence as the main indicator of chronic gastritis stage [52,53]. Although the question of comparing these classifications from the sensitivity point remains controversial, since the use of OLGIM, which is more reproducible in practical application, may underestimate the true severity of absolute (non-metaplastic) atrophy [54][55][56].…”

Section: Morphological Examinationmentioning

confidence: 99%

Chronic Autoimmune Gastritis: Modern Diagnostic Principles

et al. 2021

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This article summarizes and systematizes the available data from the literature on chronic autoimmune gastritis (CAG) in order to increase the awareness of specialists about the modern possibilities for diagnosing the disease, including its early stages. The clinical manifestation of the disease includes possible variants such as gastrointestinal, hematological (first of all, the formation of iron deficiency and B12-deficiency anemia), and neurological variants. Patients with chronic autoimmune gastritis are characterized by comorbidity with other autoimmune diseases. In this paper, data on the most informative serological markers for the diagnosis of CAG, as well as laboratory tests to detect micronutrient deficiencies, information on the characteristic changes in the gastric mucosa, and the prognosis of the disease, are presented. The diagnosis of CAG should be based on a multidisciplinary approach that combines a thorough analysis of a patient’s complaints with a mandatory assessment of nutritional status, as well as the results of serological, endoscopic, and histological research methods.

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Section: Morphological Examinationmentioning

confidence: 99%

Chronic Autoimmune Gastritis: Modern Diagnostic Principles

et al. 2021

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“…Moreover, the incidence of open-type atrophic gastritis was significantly higher in the anti-H. pylori-Ab positive group and had a strong correlation to the incompetent pylorus group. Atrophic gastritis is the first step in Correa's cascade [36]. Pathologically, original gastric glands are replaced by intestinal metaplasia and pseudopyloric metaplasia, with or without fibrosis [37].…”

Section: Discussionmentioning

confidence: 99%

“…It is estimated that 0.1% to 0.3% of atrophic gastritis cases develop into gastric adenocarcinomas annually [36]. Patients diagnosed with open-type endoscopic atrophy have a higher risk of gastric cancer development than those diagnosed with closed-type [39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Pyloric Incompetence Associated with Helicobactor pylori Infection and Correlated to the Severity of Atrophic Gastritis

et al. 2022

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Duodenogastric reflux (DGR) causes bile reflux gastritis (BRG) and may develop into gastric cancer. DGR is classified as primary in non-operated stomachs or secondary to surgical intervention. Primary DGR and Helicobacter pylori (H. pylori) infection are reportedly related. However, the mechanism is not fully understood. This study aimed to elucidate the relationship between H. pylori infection and pyloric incompetence in a non-operated stomach. A total of 502 non-operated participants who underwent an upper intestinal endoscopy were prospectively enrolled. Endoscopic findings (EAC, endoscopic atrophy classification; nodular gastritis; xanthoma; fundic gland polyp; and incompetence of pylorus), sex, age, gastrin, pepsinogen (PG) I and PG II levels were evaluated. PG I/PG II ratio, anti-H. pylori-Ab positivity, and atrophic gastritis status were significantly different between the normal and incompetent pylori (p = 0.043, <0.001, and 0.001, respectively). Open-type atrophic gastritis was significantly higher in the incompetent pylori. Incompetence of the pylorus and EAC were moderately correlated (Cramer’s V = 0.25). Multivariate analysis revealed that the presence of anti-H. pylori-Ab was the only independent factor associated with the incompetence of the pylorus, with an adjusted odds ratio of 2.70 (95% CI: 1.47–4.94, p = 0.001). In conclusion, pyloric incompetence was associated with H. pylori infection and moderately correlated to the severity of atrophic gastritis in non-operated stomachs.

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“…Das hellblaue Kamm-Zeichen (Light blue Crest) definiert als feine, blau-weiße Linien auf den Kämmen der Epitheloberfläche, ist charakteristisch für die IM, mit einer Sensitivität und Spezifität von ca. 90 % [12,13]. Die sogenannten weißen undurchsichtigen Felder (White opaque Substance) resultieren aus Ansammlungen mikroskopisch kleiner Lipidtröpfchen und stellen ebenfalls einen nützlichen Marker für das Vorliegen einer IM, mit hoher Spezifität und begrenzter Sensitivität.…”

Section: äTiologieunclassified

Autoimmungastritis

Venerito¹,

Sulzer²,

Jechorek³

2022

Dtsch Med Wochenschr

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Die Autoimmungastritis (AIG) ist eine chronische immunvermittelte Entzündung der Magenkorpus/-fundusschleimhaut, die zur progressiven Atrophie der oxyntischen Magendrüsen (AOM) und deren konsekutiven Funktionsverlust führt. Mögliche klinische Folgen der AIG sind Eisenmangelanämie, perniziöse Anämie, neuroendokrine Tumoren des Magens (gNET) und das Magenkarzinom. Dieser Beitrag bietet eine Übersicht interdisziplinärer Aspekte zur Diagnostik und Therapie der AIG.

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AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review

Cited by 234 publications

References 93 publications

Chronic Autoimmune Gastritis: Modern Diagnostic Principles

Chronic Autoimmune Gastritis: Modern Diagnostic Principles

Pyloric Incompetence Associated with Helicobactor pylori Infection and Correlated to the Severity of Atrophic Gastritis

Autoimmungastritis

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