Agamanone, a flavanone from Agave americana

Parmar, Virinder S.; Jha, Hirday N.; Gupta, Atul; Prasad, Ashok K.

doi:10.1016/0031-9422(92)83333-t

Cited by 15 publications

(7 citation statements)

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“…The presence of phenolic acids in the species here studied, all of them belonging to Agave subgenus Littaea, contrasts with their absence in A. americana (Parmar et al, 1992), A. asperrima, A. durangensis, A. shrevei, A. wocomahi, (Almaraz-Abarca et al, 2009, and A. sisalana (Chen et al, 2009), which belong to Agave subgenus Agave. If those tendencies are found in more species of both subgenera, it could be suggested that the relative abundance of phenolic acids may have some taxonomic relevance at the subgeneric level in Agave.…”

Section: Discussionmentioning

confidence: 60%

“…Derivatives of herbacetin (compound 31), and isorhamnetin derivative (compound 69) were other fl avonols also found. A complex fl avanone (5,7dihydroxi-6,5'-di-metoxi-3', 4'-metilenedioxifl avanone) present in somatic tissues (Parmar et al, 1992), and of two fl avonol glycosides (kaempferol-3-O-glucoside and kaempferol-3-O-rutinoside) from the fl owers of A. americana (Subramanian and Nair, 1970) have been reported. Also, three complex isofl avanoids have been identifi ed in the rhizomes of A. barbadensis (Tinto et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…In spite of the many taxonomic controversies about the delimitation of many species of Agave (Gentry, 1982;González-Elizondo et al, 2009), efforts focused in determining the taxonomic signifi cance of the fl avonoid profi les in this genus have been scarce. Agave americana (Parmar et al, 1992;Subramanian and Nair, 1970;Tinto et al, 2005), and A. barbadensis (Tinto et al, 2005) are among the few species of Agave studied for the fl avonoid composition, although with no taxonomic aims. For those species, complex fl avanoids were reported.…”

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Variability of the Foliar Phenol Profiles of the Agave victoriae-reginae Complex (Agavaceae).

Almaraz-Abarca¹,

González-Elizondo²,

Campos³

et al. 2013

Bot. Sci.

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Abstract:The foliar phenol profi les of eight populations of the Agave victoriae-reginae complex were determined by high performance liquid chromatography with diode array detection in order to assess the variability of those compounds across the natural distribution of the complex, and to determine their taxonomical signifi cance. With comparative aims Agave lechuguilla and A. striata were analyzed in the same manner. A total of 81 phenolic compounds were detected, comprising 18 phenolic acids, 51 fl avonoids (26 fl avonols, 19 dihydrovonoids, and six fl avones), and 12 non identifi ed phenols. Each population of the A. victoriaereginae complex showed a different foliar phenol composition, and A. pintilla, the most recently described species of the group, could be distinguished by four compounds not shared with any other analyzed population. Phenolic acids were detected in all taxa. However, a higher proportion of those compounds was found in the A. victoriae-reginae complex, while a predominance of fl avonols (quercetin-3-O-glycosides) was found in A. striata, and a codominance of dihydrofl avonoids and fl avonols in A. lechuguilla, allowing to distinguish species-specifi c profi les. Differences in the contents of some phenolic compounds among those three species and within the A. victoriae-reginae complex were also found. Our results sustain the proposal of considering A. victoriaereginae as a species complex and the separation of A. pintilla as an independent species. The results also reveal the foliar phenol patterns as valuable chemical markers in Agave. Key words: Agave lechuguilla, Agave striata, Agave victoriae-reginae, chemical variability, phenol profi les.Resumen: Se determinaron los perfi les fenólicos foliares de ocho poblaciones del complejo Agave victoriae-reginae por medio de cromatografía líquida de alta resolución con detector de arreglo de diodos para evaluar la variabilidad de esos compuestos a través de la distribución natural del complejo, y para determinar su valor taxonómico. Con fi nes comparativos Agave lechuguilla y Agave striata se analizaron de la misma manera. Se encontró un total de 81 compuestos fenólicos, que incluyeron 18 ácidos fenólicos, 51 fl avonoides (26 fl avonoles, 19 dihidrofl avonoides y seis fl avonas), además de 12 compuestos fenólicos no identifi cados. Cada población del complejo A. victoriae-reginae presentó una composición fenólica foliar diferente, y A. pintilla, la especie más recientemente descrita del grupo, se pudo distinguir por cuatro compuestos no compartidos con ninguna otra población analizada. En todos los taxa se detectaron ácidos fenólicos; sin embargo, una predominancia de estos compuestos se encontró en el complejo A. victoriae-reginae, mientras que en A. striata se encontró predominancia de fl avonoles (derivados de quercetina), y en A. lechuguilla una codominancia de dihidrofl avonoides y fl avonoles, lo que permitió discernir perfi les especie-específi cos. Diferencias en los contenidos de algunos compuestos fenólicos entre estas tres especies ...

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Variability of the Foliar Phenol Profiles of the Agave victoriae-reginae Complex (Agavaceae).

Almaraz-Abarca¹,

González-Elizondo²,

Campos³

et al. 2013

Bot. Sci.

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“…The antibacterial activity was classified as standards (>27 mm) highly active (21-27 mm), moderately active (15-21 mm), least active (12-15 mm) and less than 12 mm was taken as inactive 13 .…”

Section: Issn: 0975-8232mentioning

confidence: 99%

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2011

IJPSR

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In the present study a series of chalcone-semicarbazones was synthesized and evaluated for their antibacterial activity by paper disk diffusion method. Based on the results of an antibacterial study, compound 28 was the most active compound against gram negative bacteria. Synthesized compounds were inactive against gram positive bacteria. It was found that chlorosubstitution in the aldehydic moiety and amino substitution in acetophenic moiety of chalcone exhibited better antibacterial activity against gram negative bacteria but lengthening of carbon chain does not favor antimicrobial activity.

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“…Alkyl radicals produced from acyl peroxide or alkyl hydro peroxide give high yields of 2-substituted alkyl derivatives. Reduction (Na, C2H5OH) of quinoxaline gives a 1,2,3,4-tetrahydro Derivatives [50,51]. Quinoxaline itself is prepared by the reaction of o-phenylenediamine and glyoxal.…”

Section: Synthesis Of Quinoxalinesmentioning

confidence: 99%

Synthetic Methods and Exploring Biological Potential of Various Substituted Quinoxalin-2-one Derivatives

2016

European Reviews of Chemical Research

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Substituted quinoxaline have considerable interest in chemistry, biology and pharmacology. Quinoxaline derivatives are capable with variety of biological activities and possess different biological activities, of which the most potent are anti-microbial, analgesic and anti-inflammatory activities. It facilitated the researchers to develop various methods for their synthesis and their applications. In this review represented different methods of synthesis, reactivity and various biological activities of quinoxaline derivatives.Keywords: Quinoxaline, reactivity, biological activities, synthetic methods. IntroductionQuinoxaline and its derivatives are important nitrogen containing heterocyclic compounds of various biologically properties. Quinoxaline and its derivatives are mostly of synthetic origin. Substituted quinoxalines are an important class of benzoheterocycles, which constitute the building blocks of wide range of pharmacologically active compounds having antibacterial [1][2][3][4] [15] activities. The quinoxaline is described as a bioisoster of quinoline, naphthalene, benzothiophene and other aromatic rings such as pyridine and pyrazine. Because of the similarity between some antitubercular drugs and quinoxaline, as well as the presence of the quinoxaline moiety in some broad spectrum antibiotics, it was hoped that quinoxaline analogs would exhibit antitubercular activity [16]. The quinoxaline antibiotics are agents of bicyclic desipeptide antibiotic that have been reported activity against gram-positive bacteria and certain tumors and to inhibit RNA synthesis [17]. Quinoxaline has also been used in reactive dyes and pigments, azo dyes, fluroscein dyes and it also forms a part of certain antibiotics. Quinoxaline m.p. 29-30ºC and is miscible with water. It is weakly basic (pka 0.56) and thus considerably weaker base than the isomeric diazonapthalenes namely cinnoline (pka 2.42), pthalizine (pka 3.47) or quinazoline (pka 1.95). 2-Hydroxy-but not 2-amino quinoxaline exist in tautomeric forms.

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Agamanone, a flavanone from Agave americana

Cited by 15 publications

References 2 publications

Variability of the Foliar Phenol Profiles of the Agave victoriae-reginae Complex (Agavaceae).

Variability of the Foliar Phenol Profiles of the Agave victoriae-reginae Complex (Agavaceae).

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Synthetic Methods and Exploring Biological Potential of Various Substituted Quinoxalin-2-one Derivatives

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