Agaricus Blazei Hot Water Extract Shows Anti Quorum  Sensing Activity in the Nosocomial Human Pathogen Pseudomonas Aeruginosa

Sokóvić, Marina; Ćirić, Ana; Glamočlija, Jasmina; Nikolić, Miloš; Griensven, L. J. L. D. van

doi:10.3390/molecules19044189

Cited by 50 publications

(33 citation statements)

References 32 publications

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“…22 The effect of R. canina leaf extract on the biofilm growth of S. aureus, L. monocytogenes, P. aeruginosa, E. coli and C. albicans was tested with concentrations of the extract equal to 0.500, 0.125, 0.062 and 0.031 parts of the determined MIC values. Namely, the bacteria in biofilms can be 10 to 1000 times more tolerant to the effect of antimicrobial agents compared to their planktonic form.…”

Section: Effect On Biofilm Formation and Developmentmentioning

confidence: 99%

“…24 Once established in the patient P. aeruginosa can especially be difficult to treat. 22 Similarly, E. coli biofilms can demonstrate serious problems to human health like prostatitis, biliary tract infection as well as urinary catheter cystitis. 1 This Gram negative bacterium has low sensitivity to antibiotic treatment and has become multidrug resistant which causes an increasing public health threat.…”

Section: Effect On Biofilm Formation and Developmentmentioning

confidence: 99%

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Rosa canina L. – new possibilities for an old medicinal herb

Živković¹,

Stojković

Petrović

et al. 2015

Food Funct.

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Health beneficial properties of Rosa canina species are mainly attributed to rose hips, while the leaves are usually discarded as waste. In the present study we investigated chemical constituents as well as antimicrobial and antibiofilm potential of R. canina methanolic leaf extract. Chemical analysis showed that dominant phenolic compounds are quercetin and isorhamnetin derivatives (isoquercetin and isorhamnetin-3-O-rutinoside). Among the tested bacteria, Pseudomonas aeruginosa and Salmonella typhimurium were the most susceptible to the activity of R. canina leaf extract with MIC and MBC values both 0.009 mg mL −1 . For most of the bacterial strains investigated the extract showed significantly higher activity compared to the used standard compounds streptomycin and ampicillin. Also the tested extract powerfully inhibited in vitro biofilm growth in Pseudomonas aeruginosa, Staphylococcus aureus, Leishmania monocytogenes and Escherichia coli at sub MIC-levels. With concentrations equal to 1/4 and 1/8 of MIC values biofilm growth of P. aeruginosa and E. coli was inhibited by 90%. The obtained results are significant for a wider and efficient use of R. canina leaves.

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Section: Effect On Biofilm Formation and Developmentmentioning

confidence: 99%

Section: Effect On Biofilm Formation and Developmentmentioning

confidence: 99%

Rosa canina L. – new possibilities for an old medicinal herb

Živković¹,

Stojković

Petrović

et al. 2015

Food Funct.

Self Cite

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“…Furthermore, microorganism resistance is a challenge for health and food production, and the search for alternative natural antimicrobial agents continues (Ding et al, 2010;Soković et al, 2014). Synthetic fungicides, for instance, are generally effective and inexpensive, but it has been suggested that they leave residual toxicity that may have carcinogenic and teratogenic side effects (McCarroll et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Antifungal and antibacterial activities of Petroselinum crispum essential oil

et al. 2016

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ABSTRACT. Parsley [Petroselinum crispum (Mill.) Fuss] is regarded as an aromatic, culinary, and medicinal plant and is used in the cosmetic, food, and pharmaceutical industries. However, few studies with conflicting results have been conducted on the antimicrobial activity of parsley essential oil. In addition, there have been no reports of essential oil obtained from parsley aerial parts, except seeds, as an alternative natural antimicrobial agent. Also, microorganism resistance is still a challenge for health and food production. Based on the demand for natural products to control microorganisms, and the reevaluation of potential medicinal plants for controlling diseases, the objective of this study was to determine the chemical composition and antibacterial and antifungal activities of parsley essential oil against foodborne diseases and opportunistic pathogens. Seven bacteria and eight fungi were tested. The essential oil major compounds were apiol, myristicin, and b-phellandrene. Parsley essential oil had bacteriostatic activity against all tested bacteria, mainly Staphylococcus aureus, Listeria monocytogenes, and Salmonella enterica, at similar or lower concentrations than at least one of the controls, and bactericidal activity against all tested bacteria, mainly S. aureus, at similar or lower concentrations than at least one of the controls. This essential oil also had fungistatic activity against all tested fungi, mainly, Penicillium ochrochloron and Trichoderma viride, at lower concentrations than the ketoconazole control and fungicidal activity against all tested fungi at higher concentrations than the controls. Parsley is used in cooking and medicine, and its essential oil is an effective antimicrobial agent.

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“…This bacterium uses the ability to form a biofilm controlled by gene expression, as a resistance to the antibiotics and as a protection from the host's immune system. Anti-biofilm test applied in this study detects the inhibition of initial phase of biofilm formation (Soković et al, 2014) and according to obtained results, our samples demonstrated activity in a dosage-dependent manner. Tested essential oils in this study showed strong inhibition of the cells motility and the growth of the colonies.…”

Section: Anti-qs Activity Of Extracts and Essential Oilsmentioning

confidence: 99%

Inhibition of quorum sensing virulente factors of Pseudomonas aeruginosa PAO1 by Ferulago macedonica and Echinophora sibthorpiana extracts and essential oils

Mileski¹,

Ciric

Matevski

et al. 2017

Lek sirovine

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This study was conducted to analyse extracts and essential oils of Ferulago macedonica and Echinophora sibthorpiana (Apiaceae) for anti-quorum sensing potential using Pseudomonas aerugonisa PAO1 as biomonitoring system. Anti-quorum sensing screening was carried out by tree different tests which showed that examined samples possessed significant effects in suppressing of some virulent determinants of PAO1. The essential oils of F. macedonica and E. sibthorpiana aerial parts reduced the growth and modified the appearance of P. aeruginosa colonies and flagella to a large extent in twitching and motility assay. In the presence of essential oil of E. sibthorpiana, diameter of the colony was 6.67 mm, the flagella were absent and the color of the colony was changed from green to white. In anti-biofilm assay, the inhibitory activity of E. sibthorpiana was more notable than of F. macedonica. Applied colorimetric test revealed that examined samples strongly reduced the production of pigment pyocyanin where the highest inhibition of its synthesis showed F. macedonica oil (5.22%), followed by E. sibthorpiana oil (10.69%), which was singnificantly higher potential in comparison to used antibiotics (84.27% and 97.59% for streptomycin and ampicillin, respectively).

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Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in the Nosocomial Human Pathogen Pseudomonas Aeruginosa

Cited by 50 publications

References 32 publications

Rosa canina L. – new possibilities for an old medicinal herb

Rosa canina L. – new possibilities for an old medicinal herb

Antifungal and antibacterial activities of Petroselinum crispum essential oil

Inhibition of quorum sensing virulente factors of Pseudomonas aeruginosa PAO1 by Ferulago macedonica and Echinophora sibthorpiana extracts and essential oils

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