Agarose composite hydrogel and PVA sacrificial materials for bioprinting large-scale, personalized face-like with nutrient networks

Zou, Qiang; Tian, Xiaobin; Yuan, Daizhu; Xu, Shunen; Yang, Long; Ma, Minxian; Ye, Chuan

doi:10.1016/j.carbpol.2021.118222

Cited by 40 publications

(32 citation statements)

References 38 publications

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“…[ 97 ] For continuous and stable printing, some water‐soluble additives, such as polyvinyl alcohol (PVA) and sacrificial molds or templates, are commonly used to improve the melt rheology for FFF or act as temporary support structures, which can be easily removed by immersion in water in post‐processing. [ 98–101 ]…”

Section: D Printing Technique For Ligninmentioning

confidence: 99%

“…[97] For continuous and stable printing, some water-soluble additives, such as polyvinyl alcohol (PVA) and sacrificial molds or templates, are commonly used to improve the melt rheology for FFF or act as temporary support structures, which can be easily removed by immersion in water in post-processing. [98][99][100][101] With tunable structures and functions, materials printed by FFF have been widely used in electronics, energy storage, and bio-tissues. Raney et al [96] developed a rotational FFF 3D printing strategy that enables spatially controlled orientation of short carbon fibers (CF) in epoxy matrix (Figure 3b).…”

Section: Fused Filament Fabricationmentioning

confidence: 99%

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Lignin‐Based Materials for Additive Manufacturing: Chemistry, Processing, Structures, Properties, and Applications

et al. 2023

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The utilization of lignin, the most abundant aromatic biomass component, is at the forefront of sustainable engineering, energy, and environment research, where its abundance and low‐cost features enable widespread application. Constructing lignin into material parts with controlled and desired macro‐ and microstructures and properties via additive manufacturing has been recognized as a promising technology and paves the way to the practical application of lignin. Considering the rapid development and significant progress recently achieved in this field, a comprehensive and critical review and outlook on three‐dimensional (3D) printing of lignin is highly desirable. This article fulfils this demand with an overview on the structure of lignin and presents the state‐of‐the‐art of 3D printing of pristine lignin and lignin‐based composites, and highlights the key challenges. It is attempted to deliver better fundamental understanding of the impacts of morphology, microstructure, physical, chemical, and biological modifications, and composition/hybrids on the rheological behavior of lignin/polymer blends, as well as, on the mechanical, physical, and chemical performance of the 3D printed lignin‐based materials. The main points toward future developments involve hybrid manufacturing, in situ polymerization, and surface tension or energy driven molecular segregation are also elaborated and discussed to promote the high‐value utilization of lignin.

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Section: D Printing Technique For Ligninmentioning

confidence: 99%

Section: Fused Filament Fabricationmentioning

confidence: 99%

Lignin‐Based Materials for Additive Manufacturing: Chemistry, Processing, Structures, Properties, and Applications

et al. 2023

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“…In this regard, the sacrificial material is shaped into the core of the desired vascular network structure and then dissolved away by physical removal, such as adjusting the pH and temperature, or chemical reaction. Several materials, such as gelatin, sugar glass, agarose, alginate, pluronic and polyvinyl alcohol, have been used as sacrificial inks, to build complex vascular networks within the 3D printed structures [68,[140][141][142][143][144][145][146][147][148][149][150].…”

Section: Biomaterialsmentioning

confidence: 99%

Bioprinting Technologies and Bioinks for Vascular Model Establishment

Kong

Wang

2023

IJMS

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Clinically, large diameter artery defects (diameter larger than 6 mm) can be substituted by unbiodegradable polymers, such as polytetrafluoroethylene. There are many problems in the construction of small diameter blood vessels (diameter between 1 and 3 mm) and microvessels (diameter less than 1 mm), especially in the establishment of complex vascular models with multi-scale branched networks. Throughout history, the vascularization strategies have been divided into three major groups, including self-generated capillaries from implantation, pre-constructed vascular channels, and three-dimensional (3D) printed cell-laden hydrogels. The first group is based on the spontaneous angiogenesis behaviour of cells in the host tissues, which also lays the foundation of capillary angiogenesis in tissue engineering scaffolds. The second group is to vascularize the polymeric vessels (or scaffolds) with endothelial cells. It is hoped that the pre-constructed vessels can be connected with the vascular networks of host tissues with rapid blood perfusion. With the development of bioprinting technologies, various fabrication methods have been achieved to build hierarchical vascular networks with high-precision 3D control. In this review, the latest advances in 3D bioprinting of vascularized tissues/organs are discussed, including new printing techniques and researches on bioinks for promoting angiogenesis, especially coaxial printing, freeform reversible embedded in suspended hydrogel printing, and acoustic assisted printing technologies, and freeform reversible embedded in suspended hydrogel (flash) technology.

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“…Polyvinyl alcohol (PVA), as a synthetic polymer, has received extensive attention in the past ten years due to its light transmission, water solubility, biocompatibility, hydrophilicity, and antiseptic properties [ 58 , 59 ], and been used widely in biomedical fields [ 60 , 61 , 62 , 63 , 64 ]. PVA solutions can form hydrogels through physical entanglement of the molecular chains through many weak non-covalent bonds, including hydrogen bonds and van der Waals.…”

Section: Sacrificial Biomaterials Based On Physical Principlesmentioning

confidence: 99%

Application Status of Sacrificial Biomaterials in 3D Bioprinting

Liu

Wang

et al. 2022

Polymers

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Additive manufacturing, also known as three-dimensional (3D) printing, relates to several rapid prototyping (RP) technologies, and has shown great potential in the manufacture of organoids and even complex bioartificial organs. A major challenge for 3D bioprinting complex org unit ans is the competitive requirements with respect to structural biomimeticability, material integrability, and functional manufacturability. Over the past several years, 3D bioprinting based on sacrificial templates has shown its unique advantages in building hierarchical vascular networks in complex organs. Sacrificial biomaterials as supporting structures have been used widely in the construction of tubular tissues. The advent of suspension printing has enabled the precise printing of some soft biomaterials (e.g., collagen and fibrinogen), which were previously considered unprintable singly with cells. In addition, the introduction of sacrificial biomaterials can improve the porosity of biomaterials, making the printed structures more favorable for cell proliferation, migration and connection. In this review, we mainly consider the latest developments and applications of 3D bioprinting based on the strategy of sacrificial biomaterials, discuss the basic principles of sacrificial templates, and look forward to the broad prospects of this approach for complex organ engineering or manufacturing.

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Agarose composite hydrogel and PVA sacrificial materials for bioprinting large-scale, personalized face-like with nutrient networks

Cited by 40 publications

References 38 publications

Lignin‐Based Materials for Additive Manufacturing: Chemistry, Processing, Structures, Properties, and Applications

Lignin‐Based Materials for Additive Manufacturing: Chemistry, Processing, Structures, Properties, and Applications

Bioprinting Technologies and Bioinks for Vascular Model Establishment

Application Status of Sacrificial Biomaterials in 3D Bioprinting

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