Agatholic acid

Bates, Robert B.; Cai, Shuqun; Cantor, Ryan S.; Carducci, Michael D.; Irvine, Anthony K.; Jiorle, Beth V.; Nakkiew, Pichaya; Setzer, William N.; Trinh, Long N.

doi:10.1107/s1600536802023164

Cited by 2 publications

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References 2 publications

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“…This resin had shown cytotoxic activity against SK-MEL-28 human melanoma cells, but was inactive against the Hep-G2, MDA-MB-231, Hs 578T, MCF-7, and PC-3 cell lines [ 22 ]. The resin is rich in diterpenoids, including agatholic acid [ 51 ].…”

Section: Resultsmentioning

confidence: 99%

Antileishmanial Potential of Tropical Rainforest Plant Extracts

2014

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A total of 115 different plant extracts from our collection, representing 96 plant species, have been evaluated for in vitro antileishmanial activity against L. amazonensis promastigotes. In addition, the extracts were screened for cytotoxic activity against BALB/c mouse macrophages in order to assess a selectivity index. Crude extracts that showed a selectivity index (CC50 for macrophage / IC50 for promastigotes) ≥ 5 or with IC50 < 12.5 μg/mL against promastigotes, a total of 28 extracts, were further screened for anti-amastigote activity. A total of 25 extracts showed promising activity against L. amazonensis promastigotes with low cytotoxic activity. Ten of these extracts showed selectivity indices, (CC50 for macrophages / IC50 for amastigotes) greater than 10 and are considered “hits”, worthy candidates for further phytochemical exploration: Conostegia xalapensis methanol bark extract, Endiandra palmerstonii bark extract, Eugenia monteverdensis acetone bark extract, Eugenia sp. “fine leaf” acetone bark extract, Exothea paniculata chloroform bark extract, Mallotus paniculatus ethanol bark extract, Matelea pseudobarbata ethanol extract, Quercus insignis ethanol bark extract, Sassafras albidum dichloromethane bark extract, and Stemmadenia donnell-smithii acetone bark extract.

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Section: Resultsmentioning

confidence: 99%

Antileishmanial Potential of Tropical Rainforest Plant Extracts

2014

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Biochemical evaluation of phenolic compounds and steviol glycoside from Stevia rebaudiana extracts associated with in vitro antidiabetic potential

Zaidan

Zen

Amran

et al. 2019

Biocatalysis and Agricultural Biotechnology

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Apart from being well known to the world as herb-based sweetening additive, Stevia rebaudiana (S. rebaudiana) and its phenolic compounds are considered as a natural antidiabetic alternative to replace synthetic drugs that possess numbers of side effects. Therefore, this study was aimed to evaluate the solvent effects on the extraction of phenolic compounds and steviol glycoside identification associated with antidiabetic potential of the extracts. Total phenolic (TPC) and flavonoid (TFC) content of the extracts were quantified, while the antidiabetic activity of the extracts was determined byα-amylase andα-glucosidase inhibitory assay. As a matter of interest, TFC was found to be present at the highest concentration in ethanol extract (10.91 mg QE/g), while the presence of TPC showed no significant difference between water extract (6.65 mg GAE/g) and other organic solvents. HPLC analysis showed the abundant presence of steviol glycoside in the water extract, the principal compound suggested for treating diabetes. Furthermore, GC-MS analysis has shown the major compounds of 1-hepta-triacotanol, duvatrienediol, dihydroxanthin,β-amyrin, lupenone, phytol,γ-sitosterol, agatholic acid and fatty acids were present. In relation to the antidiabetic potential, the effects of the extracts in inhibitingα-amylase andα-glucosidase activity were investigated in vitro. Interestingly, among allS. rebaudiana extracts, water extract exhibited the most significantα-amylase inhibitory activity with IC50= 8.63μg/ml, comparable to the synthetic drug, acarbose IC50= 13.73μg/ml. These findings demonstrated that phenolic recovery was highly dependent on extraction solvent and the promising water extract as the bestα-amylase inhibitory potential with greatest steviol glycoside recovery.

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Agatholic acid

Abstract: Key indicatorsSingle-crystal X-ray study T = 170 K Mean '(C±C) = 0.010 A Ê R factor = 0.051 wR factor = 0.126 Data-to-parameter ratio = 6.2 For details of how these key indicators were automatically derived from the article, see

Cited by 2 publications

References 2 publications

Antileishmanial Potential of Tropical Rainforest Plant Extracts

Antileishmanial Potential of Tropical Rainforest Plant Extracts

Biochemical evaluation of phenolic compounds and steviol glycoside from Stevia rebaudiana extracts associated with in vitro antidiabetic potential

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