2009
DOI: 10.1161/circresaha.108.188771
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Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes

Abstract: Abstract-Excess food intake leads to obesity and diabetes, both of which are well-known independent risk factors for atherosclerosis, and both of which are growing epidemics in an aging population. We hypothesized that aging enhances the metabolic and vascular effects of high fat diet (HFD) and therefore examined the effect of age on atherosclerosis and insulin resistance in lipoprotein receptor knockout (LDLR Ϫ/Ϫ ) mice. We found that 12-month-old (middle-aged) LDLR Ϫ/Ϫ mice developed substantially worse meta… Show more

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Cited by 186 publications
(183 citation statements)
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“…In mice deficient in EC-SOD and in rats in which GSH synthesis is inhibited, blood pressure is elevated, indicating that reduced antioxidant capacity is associated with elevated blood pressure (42). In angiotensinogen-overexpresing mice, which are hypertensive, catalase overexpression prevented blood pressure elevation and protected against kidney damage (68).…”
Section: Antioxidant Defense Mechanismsmentioning
confidence: 99%
“…In mice deficient in EC-SOD and in rats in which GSH synthesis is inhibited, blood pressure is elevated, indicating that reduced antioxidant capacity is associated with elevated blood pressure (42). In angiotensinogen-overexpresing mice, which are hypertensive, catalase overexpression prevented blood pressure elevation and protected against kidney damage (68).…”
Section: Antioxidant Defense Mechanismsmentioning
confidence: 99%
“…118 Failure to upregulate antioxidant genes and reduced antioxidant capacity are also associated with age-accelerated atherosclerosis. 119 …”
Section: Vascular Antioxidant Systemsmentioning
confidence: 99%
“…Aging is associated with an increase in oxidative damages associated with a decrease in antioxidant mechanisms [28,32] accelerated by a WD [13]. The higher SOD2 activity in PI and CAT mice compared to EX mice following the WD suggests a higher production of superoxide anion in these two groups.…”
Section: Role Of Oxidative Stressmentioning
confidence: 99%