Age and Gender Differences in Cytokine  Profile of Lymph and Blood Serum

Повещенко, А. Ф.; Орлов, Н Б; Kazakov, O. V.; Повещенко, О. В.; Kim, Irina; Miller, Tatjana; Стрункин, Д. Н.; Kabakov, Alexander E.; Reiter, Tatjana; Коненков, В. И.

doi:10.4236/aar.2014.33030

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Such results may propose that the age is not risk factor that affect the serum level of the TLR 2 ; however, attention must be reflected in understanding these results because the sample size in patients and controls may not allow a strong conclusion. In addition, age can be regarded as an effective factor when we have deal at age more than 60 years, because it is often there is immune functions dysregulation, and health decline and increased sensitivity to various infectious diseases are linked with ages advance [23], as well as the significant role of TLRs in immune response of host to TB at initial stage [24]. Unluckily, the patients and controls number in the present study at age older than 60 years could not permit a reliable statistical analysis, and therefore they were distributed into < 40 and ≥ 40 years.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of TLR-2 sera levels in a sample of Iraqi pulmonary TB patients

Ali

Utba

Mankhi

2018

ijs

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The non-specific response of immunity has developed as the initial barrier for human protection from invading pathogens, which comprises certain pathogen recognition receptors (PRR) for instance toll-like receptors (TLRs). Toll like receptor 2 (TLR 2) is capable of recognizing pathogen associated molecular patterns (PAMP) coded by Mycobacterium tuberculosis. To evaluate TLR 2 level in sera of pulmonary tuberculosis (TB) patients. About 120 subjects, involving 80 patients with pulmonary TB including 40 multiple drug resistance (MDR), 20 recently diagnosed pulmonary TB (RD) and 20 recurrent TB patients named as old cases (OC), in addition to 40 apparently healthy individuals were studied as control group. Sera from 68 TB patients and 20 healthy controls were obtained for measuring TLR 2 levels by enzyme linked immunosorbent assay (ELISA). The present result revealed that serum levels of TLR 2 showed there is no significant differences between each patient's group and control except OC group given that, has decreased significantly (p<0.05). The mean ±SD of TLR 2 level in MDR, RD, OC and controls were 4.0± 2.4, 3.4±1.4, 2.2±0.9 and 4.1± 3.0 ng/ml, respectively. The results exhibited that during treatment of tuberculosis, patients with pulmonary tuberculosis showed elevated TLR 2 concentration, which looks probably in charge of regulating inflammation and infection. Consequently, this study proposes that killing of MTB could occur in the time of disease management because of effective treatment, in addition to activation and releasing of different immune system mediators via TLR 2.

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Section: Discussionmentioning

confidence: 99%

Evaluation of TLR-2 sera levels in a sample of Iraqi pulmonary TB patients

Ali

Utba

Mankhi

2018

ijs

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“…Cells that are targets for the action of IL-2 are T-lymphocytes, natural killers (NK), and macrophages. IL-2 causes the functional activation of these cell types and the secretion of other cytokines, for example, increases the production of NK cells by interferon γ (IFN-γ) [9]. There are data about the production of nervous cells of IL-1, IL-6 and TNF-α, which are critical components in the development of chronic inflammation with destruction of β-cells of the pancreas in DM type 2 [10].…”

Section: Neuroimmune and Neuroendocrine Communications: Aging Metabomentioning

confidence: 99%

Molecular Signal Integration of Aging and Diabetes Mellitus

Сарвилина¹

2018

Diabetes and Its Complications

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DM is considered as the cause of accelerated aging. Numerous biomedical studies have proved the key role of neuroimmune-endocrine interactions in the human body, which trigger the universal molecular pathways in the development of aging and DM (GH/IGF-1, Ras-MAPK, FOXO3A, sirtuin, mTOR, CETP, Timeless gene, TZAP pathways). Modern methods of proteomic and bioinformatic analysis allow us to investigate key genomicproteomic interactions that underlie diabetic nephropathy (DN) in patients with type 2 DM. The study of the formation and development of DN can become the model for studying molecular pathways of aging of kidney tissue. Future biomedical research based on methods of high-throughput screening (HTS) of a pool of target molecules will lead to great advances in the diagnosis of aging stages and DM, as well as the development of methods for the prevention and therapy of accelerated aging of the human body and various violations of carbohydrate metabolism (1D-2D/MALDI-TOF-MS, HTS, biochips, biosensors).

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Age and Gender Differences in Cytokine Profile of Lymph and Blood Serum

Cited by 2 publications

References 6 publications

Evaluation of TLR-2 sera levels in a sample of Iraqi pulmonary TB patients

Evaluation of TLR-2 sera levels in a sample of Iraqi pulmonary TB patients

Molecular Signal Integration of Aging and Diabetes Mellitus

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