Age and gender differences in incidence and case fatality trends for myocardial infarction: a 30-year follow-up. The Tromsø Study

Mannsverk, Jan; Wilsgaard, Tom; Njølstad, Inger; Hopstock, Laila Arnesdatter; Løchen, Maja‐Lisa; Mathiesen, Ellisiv B.; Thelle, Dag S.; Rasmussen, Knut; Bønaa, Kaare Harald

doi:10.1177/1741826711421081

Cited by 54 publications

(58 citation statements)

References 32 publications

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“…Acute myocardial infarction incidence and casefatality declined during 1974 to 2004. 22 Ischemic stroke incidence declined during 1995 to 2010 and case-fatality declined in men but not in women. 23 Intracerebral hemorrhage incidence showed no time trends during 1995 to 2010.…”

Section: The Blood Pressure Distributionmentioning

confidence: 99%

Longitudinal and Secular Trends in Blood Pressure Among Women and Men in Birth Cohorts Born Between 1905 and 1977

et al. 2015

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High blood pressure is a modifiable risk factor for cardiovascular disease. Previous studies showing a blood pressure decline in recent decades lack data to follow individuals born in different decades from early and middle adulthood to older age. We investigated changes in age-specific blood pressure by repeated measurements in 37973 women and men born 1905 to 1977 (aged 20–89 years) examined ≤5× between 1979 and 2008 in the population-based Tromsø Study. Mixed models were used to estimate time trends. Mean systolic and diastolic blood pressure decreased from 1979 to 2008 in both genders in the age groups 30 to 89 years. The decrease was similar in the 80th percentile and the 20th percentile of the population blood pressure distribution. The decrease in systolic blood pressure in age group 40 to 49 years was 10.6 mm Hg in women and 4.5 mm Hg in men. Systolic blood pressure increased with age in women and men born 1920 to 1949, whereas a decrease or flattening of curve was observed in the younger birth cohorts. Thus, we found both time periodic and cohort effects, and trends were more pronounced in women than in men. The findings suggest changes in blood pressure in the population rather than an effect of treatment of high-risk individuals.

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Section: The Blood Pressure Distributionmentioning

confidence: 99%

Longitudinal and Secular Trends in Blood Pressure Among Women and Men in Birth Cohorts Born Between 1905 and 1977

et al. 2015

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“…This disturbing trend of a progressive decline in the affected age group has been noted by other authors too and is well documented in literature 15 . Many factors have been implicated in this decline including early detection 16 , stressful lifestyle 17 etc.…”

Section: Discussionmentioning

confidence: 99%

Drug Utilisation Study in Intensive Cardiac Care Unit at a Tertiary Care Hospital

Patil¹,

Binjawadgi²,

Dass³

et al. 2013

jemds

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“…The definitions of incident MI and T2DM have previously been described in detail (18,20,21). Information on cancer incidence and cancer location was retrieved from the Cancer Registry of Norway.…”

Section: Definition Of Endpointsmentioning

confidence: 99%

The Phosphodiesterase 8B Gene rs4704397 is Associated with Thyroid Function, Risk of Myocardial Infarction, and Body Height: The Tromsø Study

Jorde

Schirmer

Wilsgaard

et al. 2014

Thyroid

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Objective: High serum thyrotropin (TSH) levels predict cardiovascular disease (CVD). Recently several single nucleotide polymorphisms (SNPs) associated with TSH levels have been identified, one of them being the rs4704397 SNP in the phosphodiesterase 8B (PDE8B) gene. If the relation between thyroid function and CVD is causal, one could also expect rs4704397 genotypes to predict CVD and possibly health in general. Methods: DNA was prepared and genotyping performed for rs4704397 in subjects who participated in the fourth survey of the Tromsø Study in 1994-1995 and who were registered with the endpoints myocardial infarction (MI), type 2 diabetes (T2DM), cancer, or death, as well as a randomly selected control group. Similarly, genotyping was performed in subjects who had participated in clinical trials where serum TSH, free T4 (fT4), and free T3 (fT3) were measured. Results: From the Tromsø Study, 8938 subjects without thyroid disease or thyroid medication were successfully genotyped for rs4704397. Among these, 2098 were registered with MI, 1025 with T2DM, 2748 with cancer, and 3592 had died. The minor homozygote genotype (A:A) had a median serum TSH level that was 0.29 mIU/L higher than in the major homozygote genotype (G:G). The A:A genotype had a significantly increased risk of MI as compared to the G:G genotype (1.14 [1.00-1.29], hazard ratio [confidence interval], Cox regression with adjustment for age, sex, and body mass index). No significant associations were seen with the other endpoints or CVD risk factors. Furthermore, subjects with the G:G genotype were significantly taller than subjects with the A:A genotype (mean difference 1.5 cm). In 584 subjects with serum TSH, fT4, and fT3 measurements, the subjects with the A:A genotype had significantly higher serum TSH and nonsignificantly lower serum fT3 (mean difference 0.15 pmol/L) levels than subjects with the G:G genotype. Conclusion: rs4704397 is associated with thyroid function, risk of MI, and body height. However, confirmation in other cohorts is needed before firm conclusions can be drawn.

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Age and gender differences in incidence and case fatality trends for myocardial infarction: a 30-year follow-up. The Tromsø Study

Cited by 54 publications

References 32 publications

Longitudinal and Secular Trends in Blood Pressure Among Women and Men in Birth Cohorts Born Between 1905 and 1977

Longitudinal and Secular Trends in Blood Pressure Among Women and Men in Birth Cohorts Born Between 1905 and 1977

Drug Utilisation Study in Intensive Cardiac Care Unit at a Tertiary Care Hospital

The Phosphodiesterase 8B Gene rs4704397 is Associated with Thyroid Function, Risk of Myocardial Infarction, and Body Height: The Tromsø Study

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