Age and gender may be the key points in hyperglycemic patients with <i>Helicobacter pylori</i> infection combined colorectal adenoma—author's reply

Kim, Tae Jun; Kim, Eun Ran; Chang, Dong Kyung; Kim, Young‐Ho; Hong, Sung Noh

doi:10.1111/hel.12484

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Studies have shown that [8] colorectal polyps are predominantly found in rectal and sigmoid colon, with an incidence rate of 44% to 53%, followed by the transverse colon (32% to 36%), ascending colon (14% to 20%). The larger the polyp and with age, the prevalence of colorectal polyps and the rate of cancer increases, with an average of 5-15 years, the cancer rate reaches 3%-27% [9], as shown in Figure 2. Therefore, early intervention treatment for colorectal polyps is important to reduce the incidence of colorectal cancer.…”

Section: Introductionmentioning

confidence: 93%

Progress in the treatment of colorectal polyps from the perspective of the "spleen"

2023

medcm

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Colorectal polyp refers to a kind of elevated lesion protruding from the mucosal surface of the large intestine into the intestinal lumen, and the etiology is complex and diverse. Ancient and modern medical doctors believe that "spleen deficiency" is the key mechanism of colorectal polyps, and many clinical research data show that spleen and stomach weakness, spleen deficiency and colorectal polyps are closely related, according to the principle of Chinese medicine, "seek the root cause of the disease", clinically, we can take "spleen" as the basis for the treatment of colorectal polyps. According to the principle of "treating the disease at its root" in Chinese medicine, the clinical practice can be based on the theory of "spleen" as the entry point for the treatment of colorectal polyps and the addition and subtraction of clinical evidence, thus opening up a new way of thinking for the treatment of colorectal polyps.

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Section: Introductionmentioning

confidence: 93%

Progress in the treatment of colorectal polyps from the perspective of the "spleen"

2023

medcm

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Kill Two Birds with One Stone? The Effect of Helicobacter pylori Eradication in Decreased Prevalence of Gastric Cancer and Colorectal Cancer

Kuo,

Ko,

et al. 2024

Cancers

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The connection between microbial infections and tumor formation is notably exemplified by Helicobacter pylori (H. pylori) and its association with gastric cancer (GC) and colorectal cancer (CRC). While early studies hinted at a link between H. pylori and colorectal neoplasms, comprehensive retrospective cohort studies were lacking. Recent research indicates that individuals treated for H. pylori infection experience a significant reduction in both CRC incidence and mortality, suggesting a potential role of this infection in malignancy development. Globally, H. pylori prevalence varies, with higher rates in developing countries (80–90%) compared to developed nations (20–50%). This infection is linked to chronic gastritis, peptic ulcers, and GC, highlighting the importance of understanding its epidemiology for public health interventions. H. pylori significantly increases the risk of non-cardia GC. Some meta-analyses have shown a 1.49-fold increased risk for colorectal adenomas and a 1.70-fold increase for CRC in infected individuals. Additionally, H. pylori eradication may lower the CRC risk, although the relationship is still being debated. Although eradication therapy shows promise in reducing GC incidence, concerns about antibiotic resistance pose treatment challenges. The role of H. pylori in colorectal tumors remains contentious, with some studies indicating an increased risk of colorectal adenoma, while others find minimal association. Future research should investigate the causal mechanisms between H. pylori infection and colorectal neoplasia, including factors like diabetes, to better understand its role in tumor formation and support widespread eradication efforts to prevent both gastric and colorectal cancers.

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Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma—author's reply

Cited by 2 publications

References 7 publications

Progress in the treatment of colorectal polyps from the perspective of the "spleen"

Progress in the treatment of colorectal polyps from the perspective of the "spleen"

Kill Two Birds with One Stone? The Effect of Helicobacter pylori Eradication in Decreased Prevalence of Gastric Cancer and Colorectal Cancer

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