Age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 concentrations on the Immulite 2500: results of the Study of Health in Pomerania (SHIP)

Friedrich, Nele; Krebs, Alexander; Nauck, Matthias; Wallaschofski, Henri

doi:10.1515/cclm.2010.009

Cited by 24 publications

(22 citation statements)

References 22 publications

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“…The missing positive relation in elderly men in our study might be partly explained by the lower IGF1 levels in men than in women. A recent study reported gender-specific reference ranges for different age groups (39). The serum levels of the oldest-old male subjects in our study were much lower than expected from the reference values (below 25th percentile).…”

Section: Discussioncontrasting

confidence: 74%

“…However, in contrast to recently published studies, we found no significant gender differences in IGF1 levels in the middle-aged-and oldest-old subjects (37,38). Gender differences were present for IGFBP3 levels consistent with the findings of previous studies (39). The relationship between serum IGF1 levels and handgrip strength was present only in women.…”

Section: Discussionsupporting

confidence: 69%

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Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Taekema¹,

Ling²,

Blauw³

et al. 2011

European Journal of Endocrinology

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Objective: In aging populations, poor handgrip strength has been associated with physical disability and mortality. IGF1 is an important mediator of muscle growth and regeneration affecting muscle function. We studied the relationship between circulating levels of IGF1, its binding protein 3 (IGFBP3), and handgrip strength and physical performance in middle-aged-and oldest-old subjects. Design: Cross-sectional analysis in two different cohorts composed of middle-aged-(nZ672, mean 63.9G6.7 years) and oldest-old subjects (nZ272, all 89 years). Methods: Handgrip strength, functional performance and ability, and serum levels of IGF1 and IGFBP3 were measured in all subjects and analyzed by linear regression for men and women separately. Results: IGF1 and IGFBP3 levels declined with chronological age and were positively associated with handgrip strength in middle-aged-and oldest-old women (both, P!0.05), but not in men of either age group. Furthermore, higher serum levels of IGF1 were associated with slower walking speed in oldestold men (PZ0.012), and serum levels of IGFBP3 were positively associated with activities of daily living in the oldest-old women (PZ0.002). Conclusion: The significant relationship between IGF1 levels and muscle strength found in women but not in men suggests a gender-specific influence of IGF1 on muscle strength. Further studies are necessary to test the relationship with physical performance.

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Section: Discussioncontrasting

confidence: 74%

Section: Discussionsupporting

confidence: 69%

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Taekema¹,

Ling²,

Blauw³

et al. 2011

European Journal of Endocrinology

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“…Some articles also dealt with statistical procedures suited to defi ne reference values (19) and the appropriate use of existing interlaboratory database for the same purpose (20) . Other articles have explored the importance to improve our knowledge on the reference values of " old " parameters such as blood gases (21) as well as of some new biomakers, throughout different ages (22,23) .…”

mentioning

confidence: 99%

Reference values and the journal: why the past is now present

Plebani

Lippi

2012

Clinical Chemistry and Laboratory Medicine

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“…Eight studies [60][61][62][63][64][65][66][67] employed reference curves to estimate RIs and only one study [60] calculated confidence intervals. Three studies [68][69][70] used other methods to determine RIs.…”

Section: Resultsmentioning

confidence: 99%

Statistical methods used in the calculation of geriatric reference intervals: a systematic review

Arseneau

Balion²

2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Geriatric reference intervals (RIs) are not commonly available and are rarely used. It is difficult to select a reference population from a cohort with a high degree of morbidity. Also important are the statistical approaches used to determine health-associated reference values. It is the aim of this study to examine the statistical methods used in the calculation of geriatric RIs. Methods: A search was conducted on EMBASE and Medline for articles between January 1989 and January 2014. Studies were selected if they: 1) were English primary articles; 2) performed a clinical chemistry test on a blood fraction; 3) had a population sub-group consisting of individuals ≥ 65 years of age; and 4) calculated a RI for the subgroup ≥ 65 years of age. Results: There were 64 articles identified, of which 78.1% described the RI calculation method used. RI calculation was performed by non-parametric (21.9%), parametric (42.2%), robust (3.1%), or other (17.2%) methods. Outlier detection (SD, Grubb's test, Tukey's fence, Dixon) was infrequently used and although most studies performed partitioning, only 57.8% tested the statistical significance of the partitions. Few studies (17.2%) reported confidence intervals for the RI estimates. Overall, only 14.1% of studies provided RI estimates which followed the CLSI guideline EP28-A3c. Conclusions: Statistical methods for RI calculation and partitioning varied considerably between studies and

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Age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 concentrations on the Immulite 2500: results of the Study of Health in Pomerania (SHIP)

Abstract: The use of quantile regression results in accurate calculation of age- and gender-specific reference ranges for serum IGF-I and IGFBP-3.

Cited by 24 publications

References 22 publications

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Reference values and the journal: why the past is now present

Statistical methods used in the calculation of geriatric reference intervals: a systematic review

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