Age-Associated B Cells (ABCs) in the Prognosis, Diagnosis and Therapy of Systemic Lupus Erythematosus (SLE)

Sachinidis, Athanasios; Xanthopoulos, Konstantinos; Garyfallos, Alexandros

doi:10.31138/mjr.31.3.311

Cited by 33 publications

(26 citation statements)

References 52 publications

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“…Taking into account the prognostic and/or diagnostic potential of ABCs in rheumatic diseases, 28 we believe that the enumeration of these cells could enable better management of people to be vaccinated (especially those with autoimmune/rheumatic history, as some of the post‐vaccination flares described were severe). 14 Such an approach may determine the most proper vaccination time‐points for these people and so bring the least side effects and the most effective therapeutic benefits.…”

Section: Discussionmentioning

confidence: 99%

COVID‐19 vaccination can occasionally trigger autoimmune phenomena, probably via inducing age‐associated B cells

Sachinidis

Garyfallos

2021

Int J of Rheum Dis

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Section: Discussionmentioning

confidence: 99%

COVID‐19 vaccination can occasionally trigger autoimmune phenomena, probably via inducing age‐associated B cells

Sachinidis

Garyfallos

2021

Int J of Rheum Dis

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“…DN2 cells express T-bet and CD11c, and their activation is mediated by hyper-responsiveness to TLR7 and leads to the generation of autoreactive ASCs ( 25 ). The deeper characterization of these cells, via immunophenotyping, has the potential to identify novel SLE phenotypes that associate with disease-activity ( 26 ). Moreover, the frequency of DN B cells in rheumatic arthritis is inversely correlated to a subsequent good response ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Tocilizumab Therapy on Circulating B Cells and T Helper Cells in Patients With Neuromyelitis Optica Spectrum Disorder

Liu

Zhang

et al. 2021

Front. Immunol.

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Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody, showed its therapeutic efficacy on neuromyelitis optica spectrum disorder (NMOSD). To assess the immunological effects of this drug on B cells, follicular T helper (Tfh) cells, and peripheral T helper (Tph) cells in patients with NMOSD, peripheral B cell and Tfh cell phenotypes were evaluated in 26 patients with NMOSD before and after tocilizumab treatment by nine-color flow cytometry, as well as the expression of costimulatory and co-inhibitory molecules on B cells. Results showed that the frequency of CD27+IgD− switched memory B cells, CD27-IgD- double-negative B cells, and CD27highCD38high antibody-secreting cells was increased in patients with NMOSD. Tocilizumab treatment led to a significant shift of B cells to naïve B cells from memory B cells after 3 months. Three markers on B cells associated with T-cell activation (i.e., CD86 CD69, and HLA-DR) were downregulated after tocilizumab treatment. The frequencies of total Tfh and Tph cells were decreased, whereas that of follicular regulatory T cells tended to increase. Intrinsic increased PD-L1 and PD-L2 expression was characteristic of B cells in patients with NMOSD. Tocilizumab selectively restored PD-L1 on B-cell subsets. These results provided evidence that tocilizumab enhanced B- and T-cell homoeostasis by regulating B-cell differentiation and inhibiting lymphocyte activation in patients with NMOSD.

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“…Dysregulation of B cell production, survival and turnover in older subjects affects the ability to respond to new antigens (thus influencing response to vaccination) and may cause the accumulation of class switched memory cells (IgD-CD27+), although the eventuality of such an effect is still a matter of debate ( Ventura et al, 2017 ; Aiello et al, 2019 ; Crooke et al, 2019 ; Hazeldine and Lord, 2020 ). Also, age-associated B cells (ABCs), defined as CD11b+CD11c+CD21low/-T-bet+, increase with age, and accounts for a reduction in the generation of new B cells, the release of pro-inflammatory cytokines and autoantibody production in autoimmune diseases ( Rubtsova et al, 2015 ; Hagen and Derudder, 2020 ; Pietrobon et al, 2020 ; Sachinidis et al, 2020 ; Kim C.W. et al, 2021 ).…”

Section: Acquired Immunity: B Lymphocytesmentioning

confidence: 99%

Immunopathology and Immunosenescence, the Immunological Key Words of Severe COVID-19. Is There a Role for Stem Cell Transplantation?

Ligotti

Pojero

Accardi

et al. 2021

Front. Cell Dev. Biol.

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The outcomes of Coronavirus disease-2019 (COVID-19) vary depending on the age, health status and sex of an individual, ranging from asymptomatic to lethal. From an immunologic viewpoint, the final severe lung damage observed in COVID-19 should be caused by cytokine storm, driven mainly by interleukin-6 and other pro-inflammatory cytokines. However, which immunopathogenic status precedes this “cytokine storm” and why the male older population is more severely affected, are currently unanswered questions. The aging of the immune system, i.e., immunosenescence, closely associated with a low-grade inflammatory status called “inflammageing,” should play a key role. The remodeling of both innate and adaptive immune response observed with aging can partly explain the age gradient in severity and mortality of COVID-19. This review discusses how aging impacts the immune response to the virus, focusing on possible strategies to rejuvenate the immune system with stem cell-based therapies. Indeed, due to immunomodulatory and anti-inflammatory properties, multipotent mesenchymal stem cells (MSCs) are a worth-considering option against COVID-19 adverse outcomes.

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Age-Associated B Cells (ABCs) in the Prognosis, Diagnosis and Therapy of Systemic Lupus Erythematosus (SLE)

Cited by 33 publications

References 52 publications

COVID‐19 vaccination can occasionally trigger autoimmune phenomena, probably via inducing age‐associated B cells

COVID‐19 vaccination can occasionally trigger autoimmune phenomena, probably via inducing age‐associated B cells

Effects of Tocilizumab Therapy on Circulating B Cells and T Helper Cells in Patients With Neuromyelitis Optica Spectrum Disorder

Immunopathology and Immunosenescence, the Immunological Key Words of Severe COVID-19. Is There a Role for Stem Cell Transplantation?

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