Age associated variations in human neutrophil and sperm functioning

Purandhar, Kaveri; Seshadri, Sriram

doi:10.1016/s2305-0500(13)60147-5

Cited by 7 publications

(2 citation statements)

References 53 publications

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“…In any case, differences in neutrophil function tests may also be confounded by other factors. For instance, several reports also suggest the existence of seasonal variability in neutrophil functionality (Hansen, Baptiste, Fjeldborg, & Horohov, ; Kregel & Zhang, ; Purandhar & Seshadri, ). In humans, maximum ROS production and better neutrophil adhesion seem to occur during the summer (Klink, Bednarska, Blus, Kielbik, & Sulowska, ).…”

Section: Discussionmentioning

confidence: 98%

Tamoxifen induces apoptosis and inhibits respiratory burst in equine neutrophils independently of estrogen receptors

Olave

Alvarez

Uberti

et al. 2018

Vet Pharm & Therapeutics

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Neutrophils play an important role in the exacerbation and maintenance of severe equine asthma; persistent neutrophil activity and delayed apoptosis can be harmful to surrounding tissues. Tamoxifen (TX) is a nonsteroidal estrogen receptor modulator with immunomodulatory effects and induces early apoptosis of blood and bronchoalveolar lavage neutrophils from horses with acute lung inflammation. This study investigated if the in vitro effects of tamoxifen are produced by its action on nuclear (α and β) and membrane (GPR30) estrogen receptors in healthy equine neutrophils. Results showed that TX inhibits neutrophil respiratory burst induced by opsonized zymosan in a dose‐dependent manner. Nuclear (17‐β‐Estradiol) and GPR30 cell membrane (G1) estrogen receptor agonists and their antagonists (ICI 182,780 and G15, respectively) do not block or reproduce the effect of TX. Therefore, TX does not inhibit respiratory burst through estrogen receptors. TX (8.5 μM) also increased phosphatidylserine translocation, a marker of early apoptosis, which did not occur with any of the estrogen receptor agonists or antagonists. Thus, tamoxifen generates dose‐dependent inhibition of respiratory burst and increased early apoptosis in healthy equine neutrophils, independently of nuclear or membrane estrogen receptors. Further studies are necessary to explore the signaling pathways of tamoxifen‐induced ROS inhibition and phosphatidylserine translocation.

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Section: Discussionmentioning

confidence: 98%

Tamoxifen induces apoptosis and inhibits respiratory burst in equine neutrophils independently of estrogen receptors

Olave

Alvarez

Uberti

et al. 2018

Vet Pharm & Therapeutics

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“…This is consistent with a previous study on gender difference in neutrophils in responses to cytokine stimulations and malignant growth 25 . Moreover, the aged neutrophils have also been demonstrated to be different from the young ones in human 26 . To verify the dynamic range of gene expression, reverse-transcription quantitative PCR (RT-qPCR) was performed for the fifteen common DEGs.…”

Section: Resultsmentioning

confidence: 99%

Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish

Huo

et al. 2019

Sci Rep

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We have previously demonstrated the pro-tumoral role of neutrophils using a kras-induced zebrafish hepatocarcinogenesis model. To further illustrate the molecular basis of the pro-tumoral role, Tumor-associated neutrophils (TANs) were isolated by fluorescence-activated cell sorting (FACS) and transcriptomic analyses were carried out by RNA-Seq. Differentially expressed gene profiles of TANs from larvae, male and female livers indicate great variations during liver tumorigenesis, but the common responsive canonical pathways included an immune pathway (Acute Phase Response Signaling), a liver metabolism-related pathway (LXR/RXR Activation) and Thrombin Signaling. Consistent with the pro-tumoral role of TANs, gene module analysis identified a consistent down-regulation of Cytotoxicity module, which may allow continued proliferation of malignant cells. Gene Set Enrichment Analysis indicated up-regulation of several genes promoting angiogenesis. Consistent with this, we found decreased density of blood vessels accompanied with decreased oncogenic liver sizes in neutrophil-depleted larvae. Collectively, our study has indicated some molecular mechanisms of the pro-tumoral roles of TANs in hepatocarcinogenesis, including weakened immune clearance against tumor cells and enhanced function in angiogenesis.

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Therapeutic potential of testosterone on sperm parameters and chromatin status in fresh and thawed normo and asthenozoospermic samples

Mohammadzadeh

Montazeri

Poodineh

et al. 2023

Revista Internacional de Andrología

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Age associated variations in human neutrophil and sperm functioning

Cited by 7 publications

References 53 publications

Tamoxifen induces apoptosis and inhibits respiratory burst in equine neutrophils independently of estrogen receptors

Tamoxifen induces apoptosis and inhibits respiratory burst in equine neutrophils independently of estrogen receptors

Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish

Therapeutic potential of testosterone on sperm parameters and chromatin status in fresh and thawed normo and asthenozoospermic samples

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