Age at menopause and mortality in Taiwan: A cohort analysis

Shen, Te Yi; Strong, Carol; Yu, Tsung

doi:10.1016/j.maturitas.2020.04.008

“…The mean age (SD) at menopause in Taiwan is 50.2 (±4.0) years. 18 This suggests that postmenopausal hormonal changes may be associated with the formation of SFB. Although the precise mechanism is not clear, the nasal mucosa is affected by changes in female sex hormones.…”

Section: Discussionmentioning

confidence: 99%

Differences in Clinical and Imaging Presentation of Maxillary sinus fungus ball with and without Intralesional Hyperdensity

Wu

¹

,

Lee

²

,

Yang

³

et al. 2021

Preprint

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Objectives: Maxillary sinus fungal balls (MSFBs) mostly occur in older individuals and demonstrate female predominance. Early diagnosis is important to avoid treatment delays. This study aimed to elucidate the differences in clinical and imaging presentation of MSFB with and without intralesional hyperdensity (IH). Design and setting: This was a retrospective review in a tertiary medical center. We retrospectively identified 588 patients underwent endoscopic sinus surgery procedures for MSFB between 2005 and 2018. The clinical characteristics and computed tomography (CT) findings including the presence of complete or partial opacification, IH, and odontogenic pathology were reviewed. Participants: 588 MSFB patients Results: Patients with unilateral MSFB had a mean age of 57.4 years and demonstrated female predominance (64.63%). The overall female-to-male ratio was highest at 51-60 years (2.02) and rose to 2.60 in MSFB with IH only. Compared to those with IH, MSFB without IH was significantly more common in males (OR = 2.496; P < .0001), in those with diabetes mellitus (DM) (OR = 2.094; P = .010) and adjacent maxillary odontogenic pathology (OR = 1.697; P = .030). Complete opacification on CT was less common in MSFB without IH (OR = 0.617; P = .025). Conclusion: The highest female-to-male ratio for MSFB at 51-60 years corresponded to the age of menopause. Patients with MSFB without IH were more likely to have DM, no female predominance, adjacent maxillary odontogenic pathology, and partial opacification of the sinus, compared to those with IH. These clinical features may aid earlier identification of MSFB without IH.

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“…According to age at menopause, we divided study subjects into four subgroups: (i) younger than 40 years (premature menopause); (ii) 40-44 years (early menopause); (iii) 45-49 years (relatively early menopause); (iv) 49-52 years BioMed Research International (reference category). According to median follow-up periods (in years), we divided data into two subgroups: (i) less than 13.8 years (HR) [19,22,23,25,30], less than 16.5 years (RR) [12,24,29]; (ii) more than or equal to 13.8 years (HR) [10,18,20,21,26], more than or equal to 16.5 years (RR) [27,28,31]. In terms of location, we grouped studies into three groups: America [12, 19-22, 24, 27-29], Europe [26,31], and Asian [10,18,23,25,30].…”

Section: Eligible Studiesmentioning

confidence: 99%

“…Another review by Muka and colleagues recorded an enhanced risk of cardiovascular mortality and overall mortality in women who had experienced premature or early-onset menopause [9]. Although the association between early age at natural menopause and mortality has been widely evaluated in current medical literature [9][10][11][12], there is no definite consensus on this association, possibly due to populations of different races or ethnicities, individually underpowered studies, and lack of adjusting for confounding factors. Given the accumulating data after the year 2016 [8,9,13], a more comprehensive evaluation of this association and exploration of possible reasons behind previously inconsistent reports are necessary.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis: Early Age at Natural Menopause and Risk for All-Cause and Cardiovascular Mortality

Huan

¹

,

Deng

²

,

He

³

et al. 2021

BioMed Research International

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Aims. The aim of this meta-analysis was to comprehensively evaluate the association of early age at natural menopause with the risk for all-cause and cardiovascular mortality. Methods. Literature retrieval was done on August 4, 2020. Article selection and data extraction were completed independently and in duplicate. Early age at natural menopause was grouped into premature menopause (<40 years), early menopause (40-44 years), and relatively early menopause (45-49 years). Effect-size estimates are summarized as hazard ratio (HR) or relative risk (RR) with 95% confidence interval (CI). Results. Sixteen articles involving 321,233 women were meta-analyzed. Overall analyses revealed a statistically significant association of early age at natural menopause with all-cause mortality risk ( H R adjusted = 1.08 , 95% CI: 1.03 to 1.14, P = 0.002 ; R R adjusted = 1.05 , 95% CI 1.01 to 1.08, P = 0.005 ), but not with cardiovascular mortality risk. In dose-response analyses, the association with all-cause mortality was significant for premature menopause with ( H R adjusted = 1.10 ; 95% CI: 1.01 to 1.21; P = 0.034 ) and without ( R R adjusted = 1.34 ; 95% CI: 1.08 to 1.66; P = 0.007 ) considering follow-up intervals. As for cardiovascular mortality, marginal significance was noted for premature menopause after considering follow-up intervals ( HR = 1.09 ; 95% CI: 1.00-1.19; P = 0.045 ). Subgroup analyses indicated that gender, country, and follow-up periods were possible causes of heterogeneity. There was an overall low probability of publication bias. Conclusions. Our findings indicate that premature menopause is a promising independent risk factor for both all-cause and cardiovascular mortality.

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“…Estrogen treatment is reported to decrease the risk of stone recurrence in postmenopausal women by decreasing urinary calcium and calcium oxalate saturation [22]. The mean age at menopause was 50.2 years in Taiwanese women [23].…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Study on Sex Difference in Patients With Urolithiasis: Who Is More Vulnerable to Chronic Kidney Disease?

Li

¹

,

Chien

²

,

Lu

³

et al. 2021

Preprint

0

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Background: Urolithiasis is considered a vital public health issue with a substantial burden on kidney function. Additionally, only few reports focused on the gender difference in patients with urolithiasis. Therefore, this study aimed to compare the clinical characteristics of sex difference and their potential risk for chronic kidney disease (CKD) in patients with urolithiasis.Methods: Patients diagnosed with stone disease from 2013 to 2018 were retrospectively reviewed and divided into two groups by gender. Clinical demographic characteristics, stone location, stone composition, urine chemistries, and renal function were investigated. Univariate and multivariate analyses were used to assess the relationship and potential risk of CKD between sex groups.Results: A total of 1,802 stones were included: 1,312 from men and 490 from women. Female patients had higher rate of hypertension, diabetes, and dyslipidemia. Male patients predominantly had calcium-containing stones, especially calcium oxalate stone, uric acid stone, and struvite stone. Carbonate apatite stone was more frequently found in women. Complex surgeries such as percutaneous nephrolithotomy (PCNL) and ureteroscopic lithotripsy (URSL) were more frequently performed in women than that in men. Multivariate analysis confirmed that age >60 years (odds ratios [ORs] = 6.36; 95% confidence interval [CI], 3.8–10.8), female sex (ORs = 5.31; 95% CI 3.3–8.4), uric acid stone (ORs = 3.55; 95% CI 2.0–6.4), hypertension (OR = 7.20; 95% CI 3.8–13.7), and diabetes (OR = 7.06; 95% CI 3.1–16.2) were independent predictors of poor prognoses in CKD.Conclusions: Gender is significantly associated with higher prevalence of CKD among patients with urolithiasis. Therefore, women with stone disease may need close renal function monitoring during follow-up.

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Age at menopause and mortality in Taiwan: A cohort analysis

Cited by 41 publications

References 35 publications

Differences in Clinical and Imaging Presentation of Maxillary sinus fungus ball with and without Intralesional Hyperdensity

Differences in Clinical and Imaging Presentation of Maxillary sinus fungus ball with and without Intralesional Hyperdensity

Meta-analysis: Early Age at Natural Menopause and Risk for All-Cause and Cardiovascular Mortality

A Retrospective Study on Sex Difference in Patients With Urolithiasis: Who Is More Vulnerable to Chronic Kidney Disease?

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