Age, Atrial Fibrillation, and Structural Heart Disease Are the Main Determinants of Left Atrial Fibrosis Detected by Delayed‐Enhanced Magnetic Resonance Imaging in a General Cardiology Population

Cochet, Hubert; Mouries, Amaury; Nivet, Hubert; Sacher, Frédéric; Derval, Nicolas; Denis, Arnaud; Merle, Mathilde; Relan, Jatin; Hocini, Mélèze; Haı̈ssaguerre, Michel; Laurent, François; Montaudon, Michel; Jaı̈s, Pierre

doi:10.1111/jce.12651

Cited by 175 publications

(147 citation statements)

References 29 publications

Supporting

Mentioning

133

Contrasting

Unclassified

Order By: Relevance

“…19,20 These simulations included interstitial fibrosis as microstructural discontinuities, 20 with distributions based on late-gadolinium intensity values from patients with persistent AF 21 used to infer probabilities for fibrosis inclusion in the model, resulting in heterogeneous anisotropic conduction. For 1 simulation, areas of fibrosis also included reduced conductivity and changes to the ionic properties.…”

Section: Methodsmentioning

confidence: 99%

Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation

Roney

Cantwell

Bayer

et al. 2017

Circ: Arrhythmia and Electrophysiology

112

114

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation

Roney

Cantwell

Bayer

et al. 2017

Circ: Arrhythmia and Electrophysiology

112

114

View full text Add to dashboard Cite

show abstract

“…138–141 However, in a small study of women referred for cardiac MRI, more atrial fibrosis was detected in women than in men, using delayed-enhancement magnetic resonance imaging. 142 The plasma concentrations of the inflammatory marker C-reactive protein 143 and of fibroblast growth factor-23 144 have been found to be higher in women than in men in epidemiological studies. Both factors have been associated with increased risk of AF and might contribute to increased atrial fibrosis in women.…”

Section: Pathophysiologymentioning

confidence: 99%

Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis

Rahman

Schnabel³

et al. 2016

Nat Rev Cardiol

276

184

View full text Add to dashboard Cite

Atrial fibrillation (AF) is the most common sustained arrhythmia in women and men worldwide. During the past century, a range of risk factors have been associated with AF, severe complications from the arrhythmia have been identified, and the prevalence has been increasing steadily. Whereas evidence has accumulated regarding sex differences in coronary heart disease and stroke, the differences between women and men with AF has received less attention. We review the current literature on sex-specific differences in the epidemiology of AF, including incidence, prevalence, risk factors, and genetics, and in the pathophysiology and the clinical presentation and prognosis of patients with this arrhythmia. We highlight current knowledge gaps and areas that warrant future research, which may potentially advance understanding of variation in the risk factors and complications of AF, and ultimately aid more-tailored management of the arrhythmia.

show abstract

“…Left atrial remodelling, which can be assessed invasively by quantifying areas of low-voltage left atrial signals, or with MR imaging, 21–24 is largely determined by concomitant cardiovascular conditions and possibly by duration of AF, while other factors were derived from clinical information. 25,26 It is worthwhile to consider that the effect of any AF ablation procedure is to induce further areas of delayed gadolinium enhancement. 23,27 …”

Section: Prevention Of Recurrent Atrial Fibrillation In Patients Schementioning

confidence: 99%

Catheter ablation in patients with persistent atrial fibrillation

2016

View full text Add to dashboard Cite

Catheter ablation is increasingly offered to patients who suffer from symptoms due to atrial fibrillation (AF), based on a growing body of evidence illustrating its efficacy compared with antiarrhythmic drug therapy. Approximately one-third of AF ablation procedures are currently performed in patients with persistent or long-standing persistent AF. Here, we review the available information to guide catheter ablation in these more chronic forms of AF. We identify the following principles: Our clinical ability to discriminate paroxysmal and persistent AF is limited. Pulmonary vein isolation is a reasonable and effective first approach for catheter ablation of persistent AF. Other ablation strategies are being developed and need to be properly evaluated in controlled, multicentre trials. Treatment of concomitant conditions promoting recurrent AF by life style interventions and medical therapy should be a routine adjunct to catheter ablation of persistent AF. Early rhythm control therapy has a biological rationale and trials evaluating its value are underway. There is a clear need to generate more evidence for the best approach to ablation of persistent AF beyond pulmonary vein isolation in the form of adequately powered controlled multi-centre trials.

show abstract

Age, Atrial Fibrillation, and Structural Heart Disease Are the Main Determinants of Left Atrial Fibrosis Detected by Delayed‐Enhanced Magnetic Resonance Imaging in a General Cardiology Population

Abstract: Age, history of AF, and SHD are the most powerful predictors of atrial fibrosis, as detected by MRI, in a general cardiology population. Atrial fibrosis predominates in the posterior LA wall.

Cited by 175 publications

References 29 publications

Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation

Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation

Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis

Catheter ablation in patients with persistent atrial fibrillation

Contact Info

Product

Resources

About