Age‐dependent association of <i><scp>MDM2</scp></i> promoter polymorphisms and uterine leiomyoma in <scp>S</scp>outh‐<scp>E</scp>ast <scp>I</scp>ran: A preliminary report

Salimi, Saeedeh; Hajizadeh, Azam; Khodamian, Maryam; Pejman, Atefeh; Fazeli, Kimia; Yaghmaei, Minoo

doi:10.1111/jog.12625

Cited by 15 publications

(25 citation statements)

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“…Although there are several reports about the association between polymorphisms of various cell cycle regulator proteins and UL [20,21], published reports about the association between p21 and UL are rare. The current study aimed to investigate the possible effects of p21 C98A and C70T polymorphisms and UL.…”

Section: Introductionmentioning

confidence: 90%

“…Since ULs are monoclonal tumors originated from uninhibited proliferation of a single myometrial cell; some investigations have been proposed that the imbalance in cell cycle regulation could be a primary event in the leiomyoma development [10]. There are several reports about the possible effects of different polymorphisms in genes encoding cell cycle regulatory proteins on the susceptibility to different tumors [10][11][12].…”

Section: Introductionmentioning

confidence: 98%

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The effects of p21 gene C98A polymorphism on development of uterine leiomyoma in southeast Iranian women

et al. 2016

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Uterine leiomyoma (UL) is a monoclonal tumor which arises from uninhibited proliferation of a single myometrial cell; therefore, the imbalance in cell cycle regulation could be a key event in its development. In the present study, we aimed to assess the association of p21 gene polymorphisms and UL. Genomic DNA was extracted from blood samples of 154 women with UL and 197 age-, BMI-, and ethnically matched controls. p21 C98A (rs1801270) and C70T (rs1059234) polymorphism genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The CA genotype of p21 C98A polymorphism was significantly higher in UL women (28 %) compared to the controls (18 %), and the UL risk was 1.8-fold greater in women with CA genotype compared to CC genotype before and after adjusting for age, BMI, and ethnicity (OR, 1.8 [95 % CI, 1.1 to 3]; P = 0.02). There was no association between the AA genotype of p21 C98A polymorphism and UL. Moreover, the frequency of p21 98A allele was significantly higher in the UL women compared to controls (17 vs. 12 %, p = 0.04). The p21 C70T polymorphism did not correlate with UL before and after adjusting for age, BMI, and ethnicity. There was no difference in haplotype frequency of p21 C70T and C98A polymorphisms between UL patients and the controls. CA genotype of p21 C98A polymorphism may be a risk factor for UL susceptibility; however, p21 C70T polymorphism did not associate with UL.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 98%

The effects of p21 gene C98A polymorphism on development of uterine leiomyoma in southeast Iranian women

et al. 2016

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“…Growth factors may typically stimulate the angiogenesis of leiomyoma cells as compared with adjacent normal cells (Boehm et al, 1990;Di Lieto et al, 2005). Numerous investigations have revealed that both chromosome abnormalities in UL patients as well as genetic factors play key roles in UL pathogenesis in different countries, such as Iran (Gan et al, 2015;Salimi et al, 2015;Yaghmaei et al, 2015;Salimi et al, 2016). It is believed that ACE activity may be related to tumor growth and ACE inhibitors as well as angiotensin receptor blockers, thereby contributing to the suppression of tumor growth.…”

Section: Association Of Ace I/d and Agtr1 A1166c Gene Polymorphisms Amentioning

confidence: 99%

Association of ACE I/D and AGTR1 A1166C Gene Polymorphisms and Risk of Uterine Leiomyoma: A Case-Control Study

Keshavarzi¹,

Teimoori²,

Farzaneh³

et al. 2019

Asian Pac J Cancer Prev

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Uterine leiomyomas (ULs) can be considered as the most common benign monoclonal tumors of the smooth muscle cells in the myometrium (Flynn et al., 2006). Evidence suggests that 70% of women may develop uterine fibroids. Although this disorder may be without signs and symptoms, in 40 to 50 percent of women over age 35 it may present as menorrhagia, infertility, pain, and recurrent pregnancy loss (RPL) (Marino et al., 2004; Wang et al., 2015). There are different risk factors influencing the growth of UL, including: ethnicity, smoking, family history, obesity, diet rich in meat, oral contraceptive pills, age, and biological biomarkers (Faerstein et al., 2001; Keshavarzi et al., 2017). Despite the various studies conducted to understand UL etiology, the exact mechanism of UL pathogenesis is not yet known clearly (Strawn et al., 1995). Several mechanisms have been suggested that have the effects on growth of UL, including ovarian angiogenesis, steroid hormones, growth factors, and

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“…There are numerous VEGF polymorphisms, some of which are associated with altered VEGF expression [16]. A number of genetic studies have revealed the association between UL development and genetic polymorphisms; for example, VEGF [17], estrogen receptors [18,19], XRCC1 and p53 [20], CYP1A1 [21], Catechol-O-methyl transferase [22] and MDM2 [23] genes.…”

Section: Introductionmentioning

confidence: 99%

The −2549 insertion/deletion polymorphism of VEGF gene associated with uterine leiomyoma susceptibility in women from Southeastern Iran

Keshavarzi

Salimi

Mohammadpour‐Gharehbagh

et al. 2017

Ginekol Pol

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Objectives: Vascular endothelial growth factor (VEGF) is an important angiogenic factor that regulates angiogenesis and mediates sex steroid-induced cell growth. The present study investigated the association of VEGF gene-2578C/A (rs699947) and −2549 insertion/deletion polymorphisms in the promoter region of VEGF-A gene and uterine leiomyoma susceptibility in Southeast of Iran. Material and methods:One hundred and fifty five women with uterine leiomyoma and 157 age, BMI, and ethnicity matched healthy women were enrolled in this study. VEGF gene -2578C/A polymorphism genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, and the -2549 insertion/deletion polymorphism was analyzed by PCR method. Results:The frequency of alleles and genotypes of VEGF-2578C/A polymorphism was not different between women with uterine leiomyoma and the controls; however, a significant association was revealed between II genotype of -2549 insertion/deletion (I/D) polymorphism of VEGF gene and uterine leiomyoma. Conclusions:The findings showed that VEGF gene -2549 insertion/deletion polymorphism was associated with uterine leiomyoma.

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Age‐dependent association of MDM2 promoter polymorphisms and uterine leiomyoma in South‐East Iran: A preliminary report

Abstract: MDM2 T309G polymorphism was not associated with UL and MDM2 40-bp Indel polymorphism could be an age-related risk factor for UL.

Cited by 15 publications

References 41 publications

The effects of p21 gene C98A polymorphism on development of uterine leiomyoma in southeast Iranian women

The effects of p21 gene C98A polymorphism on development of uterine leiomyoma in southeast Iranian women

Association of ACE I/D and AGTR1 A1166C Gene Polymorphisms and Risk of Uterine Leiomyoma: A Case-Control Study

The −2549 insertion/deletion polymorphism of VEGF gene associated with uterine leiomyoma susceptibility in women from Southeastern Iran

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