Age-dependent brain activation during forward and backward digit recall revealed by fMRI

Sun, Xiwen; Zhang, Xiaochu; Chen, Xiangchuan; Zhang, Peng; Bao, Min; Zhang, Daren; Chen, Jing; He, Sheng; Hu, Xiaoping

doi:10.1016/j.neuroimage.2005.01.022

Cited by 105 publications

(80 citation statements)

References 87 publications

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“…This finding is consistent with Wildgruber et al's results of greater activation in this area for backward than forward recitation of the names of the 12 months (Wildgruber et al, 1999) and Sun's findings of greater activation for backward than forward digit recall (Sun et al, 2005). In a related study, backward but not forward digit span test also elicited activation in Broca's area (Gerton et al, 2004).…”

Section: 2supporting

confidence: 90%

Neural substrates for forward and backward recitation of numbers and the alphabet: A close examination of the role of intraparietal sulcus and perisylvian areas

et al. 2006

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Section: 2supporting

confidence: 90%

Neural substrates for forward and backward recitation of numbers and the alphabet: A close examination of the role of intraparietal sulcus and perisylvian areas

et al. 2006

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“…In contrast, young adults showed a tendency toward decreased activation in the manipulation condition in these areas. Interestingly, this pattern of manipulation-specific activation is consistent with that found by Sun et al (2005) in right lateral PFC, although the specific regions showing age differences in manipulation-related activity were different across the two studies (ventrolateral PFC in Sun et al, dorsolateral PFC and IFJ in the current study). This discrepancy in location may be due to the different task demands of letter-number sequencing compared to backward digit span.…”

Section: Wm Manipulation In Older Adultssupporting

confidence: 89%

“…One exception is a recent study by Sun et al (2005), in which older and younger adults were imaged while performing versions of the forward and backward digit span test. An Age Group × Recall Order interaction was found in right inferior frontal cortex (BA 44/45), such that older adults showed more activation in this area than did young adults, but only during backward digit span.…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in neural activity during performance matched working memory manipulation

et al. 2008

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A long-standing assumption in the cognitive aging literature is that performance on working memory (WM) tasks involving serial recall is relatively unaffected by aging, whereas tasks that require the rearrangement of items prior to recall are more age-sensitive. Previous neuroimaging studies of WM have found age-related increases in neural activity in frontoparietal brain regions during simple maintenance tasks, but few have examined whether there are age-related differences that are specific to rearranging WM items. In the current study, older and younger adults' brain activity was monitored using functional magnetic resonance imaging (fMRI) as they performed WM tasks involving either maintenance or manipulation (letter-number sequencing). The paradigm was developed so that performance was equivalent across age groups in both tasks, and the manipulation condition was not more difficult than the maintenance condition. In younger adults, manipulation-related increases in activation occurred within a very focal set of regions within the canonical brain WM network, including left posterior prefrontal cortex and bilateral inferior parietal cortex. In contrast, older adults showed a much wider extent of manipulationrelated activation within this WM network, with significantly increased activity relative to younger adults found within bilateral PFC. The results suggest that activation and age-differences in lateral PFC engagement during WM manipulation conditions may reflect strategy use and controlled processing demands rather than reflect the act of manipulation per se.

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“…The extent of activation (Table 4, Figure 2a and Figure 2b and the double subtraction analysis, WMN > WMQ > N (Table 5 and Figure 3). Notably, previous studies using digit BRT do not report such activation (Zhou et al, 2006;Sun et al, 2005).…”

Section: Working Memory Task In Quiet (Wmq) and Working Memory Task Imentioning

confidence: 80%

Hippocampal-cerebellar involvement in enhancement of performance in word-based BRT with the presence of background noise: An initial fMRI study.

Manan¹,

Franz²,

Yusoff³

et al. 2012

Psychology & Neuroscience

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Background noise may impose deleterious effects on cognitive processing. However, noise below the threshold level may increase the ability to detect stimuli via stochastic resonance mechanisms (SR). The present study investigates whether task performance is deteriorated or enhanced by 5-dB SNR and, if the task performance is enhanced, whether this facilitation in performance points to a particular neural area that serves to attenuate noise and/or increase effective task performance. The areas of interest are the cerebellum and hippocampus due to their roles in working memory (WM) and their links with attention. Fifteen healthy young Malay adults performed three tasks during fMRI scanning: listening to babble noise (N), WM task in quiet (WMQ), and WM task in noise (WMN). Activated regions during N are bilateral STG and MTG. Both WM tasks produced similar activation in a network of areas in the frontal, temporal and parietal lobes. However, the two tasks demonstrated marked differences in the left hippocampus, right posterior cerebellum, and bilateral anterior cerebellum. Moreover, the results obtained from the behavioral task demonstrated that participants responded better in the presence of noise. These results support the hypothesis that the left hippocampus, right posterior cerebellum, and bilateral anterior cerebellum may be involved in attenuating noise and/or increasing attention to task performance, which could be due to SR mechanisms operating in the presence of noise. These results collectively suggest leftward asymmetries during the tasks with the right posterior cerebellum, bilateral anterior cerebellum, and left hippocampus providing compensatory attention processes, at least in the context of this study.

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Age-dependent brain activation during forward and backward digit recall revealed by fMRI

Cited by 105 publications

References 87 publications

Neural substrates for forward and backward recitation of numbers and the alphabet: A close examination of the role of intraparietal sulcus and perisylvian areas

Neural substrates for forward and backward recitation of numbers and the alphabet: A close examination of the role of intraparietal sulcus and perisylvian areas

Age-related changes in neural activity during performance matched working memory manipulation

Hippocampal-cerebellar involvement in enhancement of performance in word-based BRT with the presence of background noise: An initial fMRI study.

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