2013
DOI: 10.1134/s2079057013010104
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Age-dependent changes in phospholipid content and neutral lipid contents during aging

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Cited by 6 publications
(4 citation statements)
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“…In our study, we observed significant alterations in the levels of several sulfatide species during aging. These were gradually decreasing with progressing age, which is in line with previous findings [16]. Sulfatides are predominantly synthesized in oligodendrocytes, enriched in myelin [17,18], and contribute to the maintenance and stability of myelin structure.…”
Section: Discussionsupporting
confidence: 92%
“…In our study, we observed significant alterations in the levels of several sulfatide species during aging. These were gradually decreasing with progressing age, which is in line with previous findings [16]. Sulfatides are predominantly synthesized in oligodendrocytes, enriched in myelin [17,18], and contribute to the maintenance and stability of myelin structure.…”
Section: Discussionsupporting
confidence: 92%
“…It has been reported that, at higher passages, cells undergo several physiological modifications that could compromise or alter cellular functions [ 26 , 42 , 43 , 44 ]. However, it is not possible to determine a general law that explains this phenomenon because of the intrinsic variability in the different cell lines.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, ageing has been related to the general dysfunctions of neuronal membranes and a decline synaptic plasticity, which are responsible of cholinergic neurons disruption and the consequent deficiency in cholinergic system (Maurer & Williams, 2017; Schliebs & Arendt, 2011). The reduction in neuronal membrane functionality and the related inhibition in synaptic plasticity processes have been supposed to be the consequence of modifications in biophysical properties and in the qualitative/quantitative phospholipid (PL) composition of the plasma membrane (Egawa et al, 2016; García‐Morales et al, 2015; Ovsepian et al, 2012).…”
Section: Introductionmentioning
confidence: 99%