Age‐dependent changes in the ability to encode a novel elementary motor memory

Sawaki, Lumy; Yaseen, Zaneb; Kopylev, Leonid; Cohen, Leonardo G.

doi:10.1002/ana.10529

Cited by 141 publications

(117 citation statements)

References 21 publications

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“…Such concentrations may be reached after chronic administration in patients with Parkinson's disease, who are much older than our subjects (Kornhuber et al, 1995;Verhagen Metman et al, 1998). Although our study sample size does not permit to draw firm conclusions about the role of gender in this type of motor learning, women appeared to perform significantly worser than men in our motor-adaptation task, in accordance with the findings of Sawaki et al (2003), who reported gender differences on a simple motor-learning paradigm using flexion-extension thumb movements. Also, it lends support to the hypothesis that female hormones may modulate neural plasticity and motor-skill learning (Maki et al, 2002;Smith et al, 1999).…”

Section: Discussionsupporting

confidence: 87%

Motor-learning Impairment by Amantadine in Healthy Volunteers

Tahar

Blanchet

Doyon

2003

Neuropsychopharmacol

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NMDA receptor antagonists impair learning and memory in animal models, presumably by inhibiting long-term potentiation in the motor cortex. Human studies are limited and restricted by the paucity of safe NMDA antagonists. Here, we investigated the contribution of glutamatergic neurotransmission to the capacity of acquiring motor-adaptation learning in humans. In a double-blind design, 200 mg of amantadine (a low-affinity NMDA receptor channel blocker) or a matching placebo were given orally to groups of 14 and 13 human healthy young volunteers, respectively. Blood samples were collected 3 h after treatment to assay plasma concentrations, and the subjects were then tested using a motor-adaptation paradigm consisting of an eight-target-pointing task. To rule out drug-related generalized impairments such sedation, tests measuring motor dexterity and attention were also administered pre-and post-treatment. Comparison of the mean performance levels on the motor-adaptation task revealed that subjects in the amantadine group performed at a lower level than those in the placebo group, but this difference did not reach significance. Interestingly, however, despite plasma amantadine concentrations being relatively low, ranging from 2.09 to 4.74 mM (mean ¼ 3.3 mM), they nevertheless correlated negatively with motor learning. Furthermore, when the amantadine group was divided into low-performance and high-performance subgroups, subjects in the former subgroup displayed mean amantadine concentrations 36% higher than the latter subgroup, and performed significantly worser than the placebo group. No change in performance was found on the motor-dexterity and attention tests. Altogether, our results lend support to the hypothesis that normal NMDA receptor function is necessary for the acquisition of motor adaptation.

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Section: Discussionsupporting

confidence: 87%

Motor-learning Impairment by Amantadine in Healthy Volunteers

Tahar

Blanchet

Doyon

2003

Neuropsychopharmacol

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“…A forma mais fidedigna de se avaliar a aquisição e desenvolvimento das habilidades necessárias para que o cirurgião possa ser considerado proficiente em videocirurgia, ainda é controversa e, até o momento não há um consenso na literatura sobre os assunto 31,32 . Vários trabalhos foram publicados propondo várias formas de avaliação da proficiência do cirurgião, mas, muitos deles confundiam competência com proficiência.…”

Section: Resultados Resultados Resultados Resultados Resultadosunclassified

“…As médias do número de CVL por ano e as médias do tempo de experiência em videocirurgia e suas associações com lesões da VBP não tiveram diferenças significativas; p=0,31856 e p=0,30722 respectivamente. Da mesma forma, a idade do cirurgião isoladamente não é um fator confiável para previsão de complicações [33][34][35] . A análise estatística mostrou que nesta série houve uma baixa associação entre a idade do cirurgião e as lesões da VBP (coeficiente Phi=0,027603 e coeficiente P de Pearson=0,027592).…”

Section: Resultados Resultados Resultados Resultados Resultadosunclassified

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Curva de aprendizado e lesões iatrogênicas em colecistectomias videolaparoscópicas

Santos

Neto²

2010

Rev. Col. Bras. Cir.

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OBJETIVO: Analisar a proficiência do cirurgião em colecistectomias videolaparoscópicas, de acordo com sua curva de aprendizado, como fator de risco para as lesões iatrogênicas da via biliar principal. MÉTODOS: Estudo retrospectivo de 2285 pacientes submetidos à colecistectomias videolaparoscópicas no Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro no período de janeiro de 1992 a dezembro de 2007. As características dos cirurgiões foram avaliadas através questionário no qual se procurou identificar idade, experiência profissional em cirurgia convencional e laparoscópica e métodos de aprendizado em videocirurgia. RESULTADOS: O número de lesões da via biliar principal neste estudo foi de seis (0,26%), semelhante ao encontrado na literatura mundial. Todas ocorreram na segunda fase da curva de aprendizado, quando os cirurgiões já haviam realizado mais de 50 colecistectomias videolaparoscópicas. CONCLUSÃO: Certificado de habilitação, treinamento prévio e idade dos cirurgiões se relacionaram com as lesões da via biliar principal nesta série. Houve significância estatística na diferença entre as médias dos tempos de experiência dos cirurgiões e sua relação com as lesões.

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“…For instance, advanced age is linked with reduced capacity for plasticity and is very common in the population of ischemic stroke patients [51,[113][114][115][116][117]. Therefore, it will be necessary to define whether advanced age affects the efficacy of VNS in the context of stroke, in order to determine the patient population most likely to respond to the therapy.…”

Section: Challenges For Translating Vns Therapies Into Clinical Practmentioning

confidence: 99%

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

Hays

2016

Neurotherapeutics

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Pathological neural activity could be treated by directing specific plasticity to renormalize circuits and restore function. Rehabilitative therapies aim to promote adaptive circuit changes after neurological disease or injury, but insufficient or maladaptive plasticity often prevents a full recovery. The development of adjunctive strategies that broadly support plasticity to facilitate the benefits of rehabilitative interventions has the potential to improve treatment of a wide range of neurological disorders. Recently, stimulation of the vagus nerve in conjunction with rehabilitation has emerged as one such potential targeted plasticity therapy. Vagus nerve stimulation (VNS) drives activation of neuromodulatory nuclei that are associated with plasticity, including the cholinergic basal forebrain and the noradrenergic locus coeruleus. Repeatedly pairing brief bursts of VNS sensory or motor events drives robust, event-specific plasticity in neural circuits. Animal models of chronic tinnitus, ischemic stroke, intracerebral hemorrhage, traumatic brain injury, and post-traumatic stress disorder benefit from delivery of VNS paired with successful trials during rehabilitative training. Moreover, mounting evidence from pilot clinical trials provides an initial indication that VNS-based targeted plasticity therapies may be effective in patients with neurological diseases and injuries. Here, I provide a discussion of the current uses and potential future applications of VNS-based targeted plasticity therapies in animal models and patients, and outline challenges for clinical implementation.

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Age‐dependent changes in the ability to encode a novel elementary motor memory

Cited by 141 publications

References 21 publications

Motor-learning Impairment by Amantadine in Healthy Volunteers

Motor-learning Impairment by Amantadine in Healthy Volunteers

Curva de aprendizado e lesões iatrogênicas em colecistectomias videolaparoscópicas

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

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