Age-Dependent Effects C57BL/6 Genetic Mutations under Mice Models of Parkinson’s Disease on Motor Ability

Abstract

As literature reported, C57BL/6 A53T mutant human alpha-synuclein under the mice is one successful model related to Parkinson's disease(PD). In previous studies, over-accumulation of alpha-synuclein which lead to lewy body, were revealed to cause impairment on motor ability in Parkinson's disease mouse model. Nevertheless, in the open filed test and the rota-rod test, hyperactivity and motor ability improvements at 12 months old was found in our study.