Age differences in hippocampal subfield volumes from childhood to late adulthood

Daugherty, Ana M.; Bender, Andrew R.; Raz, Naftali; Ofen, Noa

doi:10.1002/hipo.22517

Cited by 136 publications

(176 citation statements)

References 72 publications

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“…ERC is also implicated in age-related atrophy (15)(16)(17)(18)(19) and is an early target of AD pathology. Our results, however, did not indicate a significant relationship between ERC thickness and memory performance.…”

Section: Discussionmentioning

confidence: 99%

“…We aimed to determine whether variability in associative memory performance could be explained by variability in a specific combination of structural and functional metrics. Based on prior structural findings, we hypothesized that ERC (15)(16)(17)(18)(19) and CA1-SRLM (11,28) thickness would be positively linked to associative memory performance. Motivated by prior functional findings, we hypothesized that taskrelated activity in DG/CA3 (31,(33)(34)(35) and ERC (36)(37)(38)(39)(40)(41) would be negatively linked to associative memory performance.…”

Section: Significancementioning

confidence: 99%

“…11). Studies examining age-related changes in MTL cortex suggest that anterior portions of the parahippocampal gyrus, including ERC, are particularly susceptible (15)(16)(17)(18)(19).Beyond healthy aging, postmortem studies demonstrate that ERC and CA1 are among the first regions to show preclinical Alzheimer's disease (AD) pathology (20)(21)(22). Similarly, in vivo imaging studies of patients with mild cognitive impairment (MCI) (a clinical precursor to AD) and mild AD demonstrate focal atrophy in ERC (23-25) and CA1 (e.g., ref.…”

mentioning

confidence: 99%

“…11). Studies examining age-related changes in MTL cortex suggest that anterior portions of the parahippocampal gyrus, including ERC, are particularly susceptible (15)(16)(17)(18)(19).…”

mentioning

confidence: 99%

“…Converging evidence in human studies of healthy aging using high-resolution magnetic resonance imaging (MRI) suggests disproportionate age-related atrophy in CA1 (12)(13)(14)(15), although some studies point to selective atrophy of the subiculum or DG/CA3, while others suggest changes encompassing multiple subfields (for a review, see ref. 11).…”

mentioning

confidence: 99%

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Individual differences in associative memory among older adults explained by hippocampal subfield structure and function

Carr

Bernstein

Favila

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Older adults experience impairments in episodic memory, ranging from mild to clinically significant. Given the critical role of the medial temporal lobe (MTL) in episodic memory, age-related changes in MTL structure and function may partially account for individual differences in memory. Using ultra-high-field 7T structural MRI and high-resolution 3T functional MRI (hr-fMRI), we evaluated MTL subfield thickness and function in older adults representing a spectrum of cognitive health. Participants performed an associative memory task during hr-fMRI in which they encoded and later retrieved face-name pairs. Motivated by prior research, we hypothesized that differences in performance would be explained by the following: (i) entorhinal cortex (ERC) and CA1 apical neuropil layer [CA1-stratum radiatum lacunosum moleculare (SRLM)] thickness, and (ii) activity in ERC and the dentate gyrus (DG)/CA3 region. Regression analyses revealed that this combination of factors significantly accounted for variability in memory performance. Among these metrics, CA1-SRLM thickness was positively associated with memory, whereas DG/CA3 retrieval activity was negatively associated with memory. Furthermore, including structural and functional metrics in the same model better accounted for performance than did single-modality models. These results advance the understanding of how independent but converging influences of both MTL subfield structure and function contribute to age-related memory impairment, complementing findings in the rodent and human postmortem literatures.episodic memory | hippocampus | aging | mild cognitive impairment | Alzheimer's disease E pisodic memory, or the capacity to encode and subsequently retrieve memories for events, is known to be particularly vulnerable to age-related change (1-3). Older adults show varying degrees of episodic memory impairment, ranging from mild to clinically significant. One potential factor underlying such differences is variability in the structure and function of the medial temporal lobe (MTL).The MTL is essential for episodic memory (4-7), and research across species indicates that the MTL changes in both healthy aging and in age-related neurodegenerative disease (for reviews, see refs. 8 and 9). Critically, however, the MTL is not a unitary structure. Rather, it is composed of multiple regions with differing anatomy and connectivity (see, e.g., ref. 10), including subfields of the hippocampal formation [CA1, CA2, CA3, dentate gyrus (DG), and subiculum], and the entorhinal (ERC), perirhinal (PRC), and parahippocampal (PHC) cortices (Fig. 1A). Moreover, evidence in rodents and humans suggests that these subfields are differentially affected by age, as well as by age-related disease (8, 9, 11).Converging evidence in human studies of healthy aging using high-resolution magnetic resonance imaging (MRI) suggests disproportionate age-related atrophy in CA1 (12-15), although some studies point to selective atrophy of the subiculum or DG/CA3, while others suggest changes encompassing multip...

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Section: Discussionmentioning

confidence: 99%

Section: Significancementioning

confidence: 99%

mentioning

confidence: 99%

“…11). Studies examining age-related changes in MTL cortex suggest that anterior portions of the parahippocampal gyrus, including ERC, are particularly susceptible (15)(16)(17)(18)(19).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Individual differences in associative memory among older adults explained by hippocampal subfield structure and function

Carr

Bernstein

Favila

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Alterations of contralesional hippocampal subfield volumes and relations to cognitive functions in patients with unilateral stroke

Lu,

Xing,

et al. 2024

Brain and Behavior

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BackgroundThe volumes of the hippocampal subfields are related to poststroke cognitive dysfunctions. However, it remains unclear whether contralesional hippocampal subfield volume contributes to cognitive impairment. This study aimed to investigate the volumetric differences in the contralesional hippocampal subfields between patients with left and right hemisphere strokes (LHS/RHS). Additionally, correlations between contralesional hippocampal subfield volumes and clinical outcomes were explored.MethodsFourteen LHS (13 males, 52.57 ± 7.10 years), 13 RHS (11 males, 51.23 ± 15.23 years), and 18 healthy controls (11 males, 46.94 ± 12.74 years) were enrolled. Contralesional global and regional hippocampal volumes were obtained with T1‐weighted images. Correlations between contralesional hippocampal subfield volumes and clinical outcomes, including the Montreal Cognitive Assessment (MoCA) and Mini‐Mental State Examination (MMSE), were analyzed. Bonferroni correction was applied for multiple comparisons.ResultsSignificant reductions were found in contralesional hippocampal as a whole (adjusted p = .011) and its subfield volumes, including the hippocampal tail (adjusted p = .005), cornu ammonis 1 (CA1) (adjusted p = .002), molecular layer (ML) (adjusted p = .004), granule cell and ML of the dentate gyrus (GC‐ML‐DG) (adjusted p = .015), CA3 (adjusted p = .009), and CA4 (adjusted p = .014) in the RHS group compared to the LHS group. MoCA and MMSE had positive correlations with volumes of contralesional hippocampal tail (p = .015, r = .771; p = .017, r = .763) and fimbria (p = .020, r = .750; p = .019, r = .753) in the LHS group, and CA3 (p = .007, r = .857; p = .009, r = .838) in the RHS group, respectively.ConclusionUnilateral stroke caused volumetric differences in different hippocampal subfields contralesionally, which correlated to cognitive impairment. RHS leads to greater volumetric reduction in the whole contralesional hippocampus and specific subfields (hippocampal tail, CA1, ML, GC‐ML‐DG, CA3, and CA4) compared to LHS. These changes are correlated with cognitive impairments, potentially due to disrupted neural pathways and interhemispheric communication.

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Memory and the hippocampal formation following pediatric traumatic brain injury

DeMaster¹,

Johnson²,

Juranek³

et al. 2017

Brain and Behavior

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IntroductionPrevious research indicates disruption of learning and memory in children who have experienced traumatic brain injury (TBI).ObjectiveThis research evaluates the impact of pediatric TBI on volumetric differences along the long axis of the hippocampus, a region of the brain that is critical for explicit memory.MethodsStructural brain data and behavioral measures were collected 6 weeks following TBI or extracranial injury (EI), in children aged 8–15 years and from a group of age matched typically developing controls (TDC). Total hippocampal volume and hippocampal subregion volumes corresponding to hippocampal head, body, and tail were compared across groups and were examined in relation to verbal and visual memory.ResultsGroup differences were evident such that hippocampal body volume was found to be smaller for TBI and EI groups compared to the TDC group. Analysis restricted to the TBI group indicated that hippocampal head volume was associated with severity of injury. The relation between severity of injury and hippocampal head volume is particularly important considering results from our investigation of hippocampal volume‐to‐memory performance relations indicating positive correlations between hippocampal head volume and performance on memory measures for both the TBI group and the TDC group. Significant negative correlations between hippocampal body volume and memory were evident for the TBI group but not EI or TDC groups. Correlations between memory performance and hippocampal tail volume were not significant for the TBI or TDC groups, although for the EI group, a positive correlation was found between hippocampal tail volume and memory.ConclusionTogether these results underscore an important relation between hippocampal structure and memory function during the subacute stage of recovery from pediatric TBI.

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Age differences in hippocampal subfield volumes from childhood to late adulthood

Cited by 136 publications

References 72 publications

Individual differences in associative memory among older adults explained by hippocampal subfield structure and function

Individual differences in associative memory among older adults explained by hippocampal subfield structure and function

Alterations of contralesional hippocampal subfield volumes and relations to cognitive functions in patients with unilateral stroke

Memory and the hippocampal formation following pediatric traumatic brain injury

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