Age, gender, and 11 comorbidities as risk factors associated with COVID-19 mortality: A retrospective cohort including 1.8 million individuals

Cruz, Jonas Carneiro; Martins, Carolina Kakiuthi; Katchborian-Neto, Albert; Araújo, Cristiano Miranda de; Dellalibera-Joviliano, Renata; Barbosa, Fernando

doi:10.1080/15287394.2023.2223598

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…Some of the infected patients develop a more severe illness, and experience an extensive systemic inflammatory response with a "cytokine storm", severe lung damage, acute respiratory distress syndrome (ARDS), multiorgan failure, and a higher risk of death (2). This has been attributed to several risk factors, including age and medical conditions such as cardiovascular disease, diabetes, chronic respiratory disease, or cancer (3)(4)(5). Supportive life-saving treatments have been proposed and are being applied to severely sick COVID-19 patients with an understanding that patients who need them should receive them as early as possible (6).…”

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confidence: 99%

Circulating mortalin in blood and activation of the alternative complement pathway as risk indicators in COVID-19 infection

Avraham,

Sinkovits,

Hurler

et al. 2024

Front. Immunol.

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BackgroundMortalin/GRP75 is a ubiquitous mitochondrial chaperone related to the cytosolic heat shock protein 70. It protects cells from various types of damages and from senescence. Our goal was to determine whether COVID-19 patients have circulating mortalin in their blood and to assess its prognostic value in anticipating disease severity.MethodsMortalin was determined by ELISA in the sera of 83 COVID-19 patients enrolled in the study. Patients were categorized into 4 groups: critical patients who died (FATAL) or required intensive care and survived (ICU), patients of mild severity (hospitalized but not critical) who required nasal oxygen support (HOSP+O2), and patients who did not need oxygen therapy (HOSP).ResultsThe mortalin concentration in the serum of all COVID-19 patients in the cohort was 194-2324 pg/mL. A comparison of the mortalin levels by peak severity among the various patient groups showed a highly significant difference between the HOSP and FATAL groups and a significant difference between the HOSP and the ICU groups. COVID-19 patients who eventually failed to survive had at hospitalization a markedly higher level of mortalin in their sera. Cox regression analysis revealed a high mortality hazard (HR=3.96, p<0.01) in patients with high mortalin circulating levels (above the median, ≥651 pg/mL). This was confirmed in survival curve analysis (Kaplan-Meier; p=0.0032, log-rank test). Mortalin remained an independent predictor of mortality even after adjusting for age and sex or various complement activation products. Complement activation data collected in an earlier study in the same cohort was compared regarding the mortalin levels. Patients with higher circulating mortalin levels also had higher levels of complement C3a but reduced levels of properdin.DiscussionThis is the first report on circulating mortalin in COVID-19 patients. Higher mortalin levels were associated with more severe illnesses and a higher risk of death. We claim that quantifying the blood levels of mortalin and activated complement proteins will provide important information on the prognosis of COVID-19 patients and will serve as a useful tool for guiding their clinical management and treatment.

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Section: Introductionmentioning

confidence: 99%

Circulating mortalin in blood and activation of the alternative complement pathway as risk indicators in COVID-19 infection

Avraham,

Sinkovits,

Hurler

et al. 2024

Front. Immunol.

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Perceived health-related quality of life in people living with HIV co-infected with SARS-CoV-2 in France

Amboise,

Yaya,

Yombo-Kokule

et al. 2024

Qual Life Res

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Purpose We aimed to assess health-related quality of life (HRQL) and its correlates among people living with HIV/AIDS (PLWHA) co-infected with SARS-CoV-2 in France. Methods This cross-sectional was study conducted among PLWHA co-infected with SARS-CoV-2. HRQL was measured using the four dimensions of the PROQOL-HIV scale. Factors associated with each dimension were identified using linear regression. Results mean (SD) scores for HRQL dimensions: 76.7 (± 21.1) for Physical Health and Symptoms (PHS), 79.2 (± 23.6) for Social Relationships (SR), 67.3 (± 27.4) for Mental and Cognitive (MC), and 83.9 (± 16.5) for Treatment Impact (TI). Employment status and COVID-19 knowledge were associated with higher PHS score, while blood transfusion-acquired HIV, CDC HIV, hospital discharge instructions, and self-reported symptoms were associated with lower PHS score. Couple status was associated with higher SR score, whereas, hospital discharge instructions, CDC HIV stage C, drug injection-acquired HIV, self-reported symptoms, and COVID-19 vulnerability perception were associated with lower SR score. Employment status and French birth were associated with higher MC score, while female sex, detectable HIV viral load, hospital discharge instructions, COVID-19 vulnerability perception, smoking, and self-reported symptoms were associated with lower MC score. French birth and homosexual/bisexual relationships-acquired HIV were associated with higher TI score, while detectable HIV viral load, psychiatric disorders, and self-reported symptoms were associated with lower TI score Conclusion Among PLWHA co-infected with SARS-CoV-2, the scores of HRQL were impaired, particularly in the MC dimension. Findings underscore the multidimensional nature of HRQL, with notable variations across different dimensions. Understanding these correlates is crucial for tailored interventions aimed at improving the well-being of this population.

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Age, gender, and 11 comorbidities as risk factors associated with COVID-19 mortality: A retrospective cohort including 1.8 million individuals

Cited by 2 publications

References 54 publications

Circulating mortalin in blood and activation of the alternative complement pathway as risk indicators in COVID-19 infection

Circulating mortalin in blood and activation of the alternative complement pathway as risk indicators in COVID-19 infection

Perceived health-related quality of life in people living with HIV co-infected with SARS-CoV-2 in France

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