Age-related cardiovascular changes and diseases

Seki, Atsushi; Fishbein, Michael C.

doi:10.1016/b978-0-12-822224-9.00004-9

Cited by 4 publications

(2 citation statements)

References 243 publications

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“…Age-related structural changes occurring at cellular levels are often observed in endothelial cells, cardiomyocytes, pericardial cells, cells of the conduction system, and other cells such as fibroblasts. During the aging process, endocardial cells become thicker with some opaque areas, which seem to be more noted in the LA [ 23 ]. Moreover, endocardial thickening is observed in the borderline of the valves, where the degree of structural modifications is related to age-dependent valve thickening [ 24 ].…”

Section: Age-dependent Cardiac Structural and Functional Modificationsmentioning

confidence: 99%

Cardiac System during the Aging Process

Ribeiro¹,

Zerolo²,

López-Espuela³

et al. 2023

Aging and disease

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The aging process is accompanied by a continuous decline of the cardiac system, disrupting the homeostatic regulation of cells, organs, and systems. Aging increases the prevalence of cardiovascular diseases, thus heart failure and mortality. Understanding the cardiac aging process is of pivotal importance once it allows us to design strategies to prevent age-related cardiac events and increasing the quality of live in the elderly. In this review we provide an overview of the cardiac aging process focus on the following topics: cardiac structural and functional modifications; cellular mechanisms of cardiac dysfunction in the aging; genetics and epigenetics in the development of cardiac diseases; and aging heart and response to the exercise.

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Section: Age-dependent Cardiac Structural and Functional Modificationsmentioning

confidence: 99%

Cardiac System during the Aging Process

Ribeiro¹,

Zerolo²,

López-Espuela³

et al. 2023

Aging and disease

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“…Cardiovascular diseases, including atherosclerosis, high blood pressure and heart attack, have a direct relationship with aging (9) One of the most important problems in the field of health and treatment is heart failure, and its occurrence is associated with high morbidity and mortality and significant care and treatment costs (10). Many studies have been conducted in the field of identifying the best predictors of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Nordic Walking on the Galectin 3 and Some New Metabolic Markers in Elderly Men with Osteosarcopenic Obesity

Mirzaee,

Omidi,

Yousefi

2024

J Clin Res Paramed Sci

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Background: Sarcopenia is the age-related progressive loss of muscle mass and strength. The main symptom of the condition is muscle weakness. Objectives: The aim of the present study was to determine the effect of 12 weeks of Nordic walking on the expression of the cardiovascular biomarker galectin 3 gene and some new metabolic markers in elderly men with osteosarcopenic obesity. Methods: Twenty elderly men with a Mean age of 60 to 80 years, who had osteosarcopenic obesity with a body mass index (equal to and above 30) and body fat percentage (equal to and above 30) participated in this research and they were randomly divided into 2 Nordic walking training groups and a control group (10 people in each group). The Nordic walking training program was implemented for 12 weeks and 3 days a week. The intensity of the exercises in each session was 50 to 75% of the maximum heart rate and the duration of each exercise session was 60 minutes. Results: 12 weeks of Nordic walking exercises caused a significant decrease in the circulating levels of galectin-3 (P = 0.001) and a decrease in the TyG-BMI index (P = 0.001) in the subjects. But there was no significant effect on the atherogenic index of plasma (AIP) (P = 0.265) and TyG (P = 0.126) and TyG-BMI (P = 0.347) indices of the subjects. Conclusions: Nordic walking exercise plays an important role in reducing cardiovascular risks by reducing galectin 3 biomarker and atherogenic plasma index (AIP).

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