Age-related changes in aortic and mitral valve thickness: Implications for two-dimensional echocardiography based on an autopsy study of 200 normal human hearts

Establishing Normative Value of Mitral Valve Thickness Determined by 2d Echocardiography in 3000 Normal Children Aged 5 - 15 Years of Manipur , a North - Eastern Indian State

“…(15) The difference in our finding is that the valve thickness appears to be more in individuals with higher BMI and higher SBP compared to the respective lower groups.…”

“…For 3 age groups (Less than 20, 20 to 59 and greater than or equal to 60 years), the corresponding mean thicknesses (mm) of the aortic nodule were 0.67, 0.87 and 1.42; those for the anterior mitral leaflet were 1.30, 1.60 and 3.20. (15) Normal valve thickness was shown to be agerelated by Sahasakul et al in a well-designed postmortem study (level 2++ evidence), and correlation between surgical and echocardiographic measurements seems to be good if harmonic imaging is not used, as this modality increases apparent tissue thickness. (10,(15)(16)(17)(18)(19) On the basis of data from a study of 280 healthy children in New Zealand.…”

“…(15) Normal valve thickness was shown to be agerelated by Sahasakul et al in a well-designed postmortem study (level 2++ evidence), and correlation between surgical and echocardiographic measurements seems to be good if harmonic imaging is not used, as this modality increases apparent tissue thickness. (10,(15)(16)(17)(18)(19) On the basis of data from a study of 280 healthy children in New Zealand. (20) the normal echocardiographic thickness of the anterior MV leaflet (AMVL) in school-aged children is 1.12-2.92 mm (mean±SD of 2.02±2mm) (level 2++ evidence).…”

Screening for asymptomatic rheumatic heart disease: Understanding the mechanisms key to the diagnostic criteria

“…Modification of this methodology might be one strategy of bringing normal AMVL thickness measurements by echocardiography (normal up to 3mm with harmonics off and possibly up to 4mm with harmonics on) more in line with leaflet thickness measurements quoted from pathology studies (around 1mm in the typical screening ages and up to 1.6mm in the older patient population). (16,23,24) The effect that ultrasound pulse length has on increasing apparent leaflet thickness is unlikely to account for a three-fold increase in this measurement on fundamental imaging and if relevant could be accounted for by using a leading-edge-to-leading-edge measurement convention.…”

Role of Echocardiography in Research into Neglected Cardiovascular Diseases in Sub-Saharan Africa

“…Regarding the aortic valve both the parasternal and subcostal views allow adequate evaluation. Valve thickness of both mitral and aortic valves increases with age, based on an autopsy study (Sahsakul et al, 1988). However, in populations where RHD is prevalent there are very few additional conditions that are associated with increased thickness of the mitral valve in the age groups affected by RHVD, except for endemic areas for both RHD and EMF .…”