Age-Related Changes in Contractile Responses of Rabbit Lower Urinary Tract to Endothelin

Wada, Yasuhiko; Latifpour, Jamshid; Sanematsu, Hiromi; Afiatpour, P.; WANG, ZEJING; Saito, Motoaki; Nishi, Kazuhiko; Weiß, Robert M.

doi:10.1097/00005392-200009010-00054

Cited by 9 publications

(12 citation statements)

References 29 publications

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“…It is further speculated that changes in the amount of released ET-1 might alter the duration of sustained activation of individual smooth muscle cells and consequently alter the threshold for activation of afferent nerves and initiation of the next micturition. Ageing (35) and some popular diseases, such as diabetes mellitus (5,26,31), are known to alter ET receptor expression and bladder activity.…”

Section: Discussionmentioning

confidence: 99%

“…Because the ET-1 produced in various cells within the urinary bladder presumably modulates the bladder tone (8,34), it is intriguing to explore the mechanisms underlying ET-1induced detrusor contractions. Furthermore, bladder ET receptor expression and activities are known to change under pathological conditions, such as urethral obstruction (20)(21)(22), diabetes (5,26,31), and ageing (35). Therefore, it is possible that ET receptors and/or their downstream intracellular mechanisms may become a target for pharmacological intervention in the treatment of urinary tract disorders and incontinence.…”

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confidence: 99%

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Inward current oscillation underlying tonic contraction caused via ET_A receptors in pig detrusor smooth muscle

Kajioka¹,

Nakayama²,

McCoy³

et al. 2004

American Journal of Physiology-Renal Physiology

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Endothelin-1 (ET-1) is a powerful vasoconstricting peptide. Recent studies showed synthesis of ET-1 and the presence of ET receptors in urinary bladder smooth muscle cells. In the present study, we investigated the possible role of ET-1 in detrusor contraction and its underlying mechanisms in terms of electrical activity. ET-1 caused dose-dependent tonic contraction of bladder smooth muscle strips. Whole cell patch-clamp experiments revealed that ET-1 induced a single transient inward current in the majority of detrusor cells and that additional inward current oscillations were induced in one-third of the cells. The inward current oscillation and tonic contraction shared several characteristic features: 1) both activities lasted for a considerable time after ET-1 washout and 2) only prior application of ETA receptor antagonists, not ETB receptor antagonists, significantly suppressed ET-1-induced contractions and the oscillating inward currents. It was concluded that the inward current oscillation underlies ET-1-induced tonic contraction. Experiments with ion substitution and channel blockers suggested that periodic activation of Ca2+-activated Cl- channels caused the oscillating inward currents.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Inward current oscillation underlying tonic contraction caused via ET_A receptors in pig detrusor smooth muscle

Kajioka¹,

Nakayama²,

McCoy³

et al. 2004

American Journal of Physiology-Renal Physiology

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“…ET receptors have been demonstrated in the urethral smooth muscle in several species (Latifpour et al, 1995; Afiatpour et al, 2003). ET A -mediated smooth muscle contractions of the urethra in the rabbit have been demonstrated (Wada et al, 2000). …”

Section: 6 Endothelin/receptors System In Lut Pathwaysmentioning

confidence: 99%

Neuropeptides in Lower Urinary Tract Function

Arms

Vizzard

2011

Urinary Tract

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Numerous neuropeptide/receptor systems including vasoactive intestinal polypeptide, pituitary adenylate cyclase-activating polypeptide, calcitonin gene-related peptide, substance P, neurokinin A, bradykinin, and endothelin-1 are expressed in the lower urinary tract (LUT) in both neural and non-neural (e.g., urothelium) components. LUT neuropeptide immunoreactivity is present in afferent and autonomic efferent neurons innervating the bladder and urethra and in the urothelium of the urinary bladder. Neuropeptides have tissue-specific distributions and functions in the LUT and exhibit neuroplastic changes in expression and function with LUT dysfunction following neural injury, inflammation and disease. LUT dysfunction with abnormal voiding including urinary urgency, increased voiding frequency, nocturia, urinary incontinence and pain may reflect a change in the balance of neuropeptides in bladder reflex pathways. LUT neuropeptide/receptor systems may represent potential targets for therapeutic intervention.

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“…As to endothelin, it has been observed that the vascular response to the peptide decreases, whereas the release of ET-1 from the endothelium increases with increasing age (Dohi, Kojima, Sato, & Luscher, 1995). A similar reduction in the contractile responsiveness to ET-1 has been recently found in regions different from vascular tissues, associated (Afiatpour et al, 2003;Preuss, Rigby, & Goldie, 2000) or not (Wada et al, 2000) with receptor alterations.…”

Section: Discussionmentioning

confidence: 54%

Age-Related Changes in Endothelin-1 Receptor Subtypes in Rat Heart

Maltinti

Giannessi

et al. 2008

Experimental Aging Research

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Density, affinity, and subtype distribution of endothelin-1 (ET-1) binding sites were determined in rat cardiac tissue as a function of age in order to evaluate the association of alterations in the endothelin receptor system and aging in the heart. A significant decrease in the receptor subtype ET-A, which represents 70% to 80% of the total receptor population in cardiac tissue of 3- and 12-month-old rats, was observed in 24-month-old rats with respect to the younger groups. These findings indicate an alteration in ET-1 cardiac receptors associated with aging, mainly due to a variation in the receptor subtype distribution.

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Age-Related Changes in Contractile Responses of Rabbit Lower Urinary Tract to Endothelin

Cited by 9 publications

References 29 publications

Inward current oscillation underlying tonic contraction caused via ET_A receptors in pig detrusor smooth muscle

Inward current oscillation underlying tonic contraction caused via ET_A receptors in pig detrusor smooth muscle

Neuropeptides in Lower Urinary Tract Function

Age-Related Changes in Endothelin-1 Receptor Subtypes in Rat Heart

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Age-Related Changes in Contractile Responses of Rabbit Lower Urinary Tract to Endothelin

Cited by 9 publications

References 29 publications

Inward current oscillation underlying tonic contraction caused via ETA receptors in pig detrusor smooth muscle

Inward current oscillation underlying tonic contraction caused via ETA receptors in pig detrusor smooth muscle

Neuropeptides in Lower Urinary Tract Function

Age-Related Changes in Endothelin-1 Receptor Subtypes in Rat Heart

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Product

Resources

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Inward current oscillation underlying tonic contraction caused via ET_A receptors in pig detrusor smooth muscle

Inward current oscillation underlying tonic contraction caused via ET_A receptors in pig detrusor smooth muscle