Age-related changes in GAD levels in the central auditory system of the rat

Burianová, Jana; Ouda, Ladislav; Profant, Oliver; Syka, Josef

doi:10.1016/j.exger.2008.09.012

Cited by 112 publications

(99 citation statements)

References 85 publications

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“…In aged animals, presynaptic and postsynaptic levels of the inhibitory neurotransmitters glycine and GABA and their respective receptors are significantly reduced (Banay-Schwartz et al, 1989;Milbrandt et al, 1994Milbrandt et al, , 1996Milbrandt et al, , 1997Milbrandt et al, , 2000Willott et al, 1997;Krenning et al, 1998;Burianova et al, 2009), potentially disrupting the balance of excitation and inhibition.…”

Section: Introductionmentioning

confidence: 99%

Impaired Auditory Temporal Selectivity in the Inferior Colliculus of Aged Mongolian Gerbils

Khouri

Lesica

Grothe

2011

Journal of Neuroscience

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Aged humans show severe difficulties in temporal auditory processing tasks (e.g., speech recognition in noise, low-frequency sound localization, gap detection). A degradation of auditory function with age is also evident in experimental animals. To investigate agerelated changes in temporal processing, we compared extracellular responses to temporally variable pulse trains and human speech in the inferior colliculus of young adult (3 month) and aged (3 years) Mongolian gerbils. We observed a significant decrease of selectivity to the pulsetrainsinneuronalresponsesfromagedanimals.Thisdecreaseinselectivityled,onthepopulationlevel,toanincreaseinsignalcorrelations and therefore a decrease in heterogeneity of temporal receptive fields and a decreased efficiency in encoding of speech signals. A decrease in selectivity to temporal modulations is consistent with a downregulation of the inhibitory transmitter system in aged animals. These alterations in temporal processing could underlie declines in the aging auditory system, which are unrelated to peripheral hearing loss. These declines cannot be compensated by traditional hearing aids (that rely on amplification of sound) but may rather require pharmacological treatment.

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Section: Introductionmentioning

confidence: 99%

Impaired Auditory Temporal Selectivity in the Inferior Colliculus of Aged Mongolian Gerbils

Khouri

Lesica

Grothe

2011

Journal of Neuroscience

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“…These changes can result in hearing loss, especially at high frequencies, with impaired speech recognition. [7][8][9] In terms of the core component, meanwhile, changes in the temporal processing of complex acoustic stimuli have been described. This alteration may be related to the reduction of inhibitory neurotransmitters, which permeate the temporal processing of rapid complex acoustic stimuli.…”

Section: Introductionmentioning

confidence: 99%

“…This alteration may be related to the reduction of inhibitory neurotransmitters, which permeate the temporal processing of rapid complex acoustic stimuli. 8,9 Hearing loss can limit or prevent the individual from fulfilling his or her social role, resulting in negative emotional and professional effects. Due to sensory deprivation, the individual becomes unable to communicate properly with others, causing frustration and leading to a deterioration in quality of life.…”

Section: Introductionmentioning

confidence: 99%

Peripheral and central auditory assessment in among the elderly

Samelli

Matas

Rabelo

et al. 2016

Rev. bras. geriatr. gerontol.

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Introduction: Presbycusis can affect different portions of the auditory system, causing impacts of varying degrees of seriousness on the daily routine of elderly persons. It is essential that the extent of the deficit as well as the degree of handicap is evaluated, so that the hearing of the elderly can be effectively rehabilitated, improving their quality of life. Purpose: To characterize the peripheral and central hearing of elderly individuals and assess their auditory handicaps. Methods: A cross sectional observational study was performed. We evaluated 83 elderly persons (60-85 years; 33 men, 50 women) with normal hearing or sensorineural hearing loss. Individuals were divided into 3 groups according to the 3 to 6kHz hearing thresholds: G1 -mean of 0 to 39 dBHL (80 ears); G2 -mean of 40 to 59 dBHL (48 ears); G3 -mean of 60 to 120dBHL (38 ears). All individuals responded to the Hearing Handicap Inventory for the Elderly (HHIE), and underwent Pure Tone Audiometry, Auditory Brainstem Response (ABR) and Long Latency Response (P300) evaluation. Results: Men had higher auditory thresholds at frequencies from 500 to 12,000Hz (with a statistical difference between 2-8 kHz) and also significantly greater latencies for ABR components. There was no difference between genders for the P300 evaluation. Comparison between groups showed: a statistically significant difference for age; greater ABR wave latencies and interwave intervals; that questionnaire scores worsened as hearing threshold declined; and similar P300 latencies. Conclusions: Elderly people have impairment throughout the auditory pathway (peripheral and central). The P300 was less accurate at identifying the losses that come with age. The HHIE demonstrated negative effects on the social life of elderly people, agreeing with the hearing thresholds found.

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“…One animal model of aging in rats demonstrated an age-related decrease in the number of SMI-32 neurons (Burianová et al 2009, Syka 2016) and inhibitory GABAergic interneurons that are associated with determining the time parameters of sounds (Syka 2016). These experiments suggest that the central auditory system is associated with a decreased capacity for inhibitory processes, which may negatively impact the ability to differentiate rapid changes in sound stimuli and to differentiate them from background noise (Syka 2016).…”

Section: Introductionmentioning

confidence: 99%

Influence of age on speech intelligibility in babble noise

Černý¹,

Vokřál²,

Dlouhá³

2018

Acta Neurobiologiae Experimentalis

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Problems with hearing aids, particularly with regard to speech intelligibility in the presence of noise, are commonly reported by older individuals in everyday practice. The main goal of this study was to measure differences in speech intelligibility between older and younger people and to establish how speech intelligibility in competitive noise differs between younger and older populations with similar hearing status. More than 400 persons were tested using the Czech Test of Sentence Intelligibility in Babble Noise and divided into younger (40-65 years) and older (66-85 years) age groups. Test performance was compared between age groups based on subgroups stratified by SRT values (speech reception threshold in word audiometry in silence). Results showed a significant correlation between older age and diminished sentence intelligibility in competitive noise. Evaluation using a nonparametric U-test showed a statistical difference between the younger and older groups in sentence intelligibility, with a speech signal presented at 65 dB sound pressure level (SPL) and competitive babble noise also presented at 65 dB SPL. Increased difficulty in the use of hearing aids in older users is related, among other things, to a reduced ability to discriminate speech not only in silence but particularly in competitive variable noise due both to their aging auditory functions and to a diminished capacity to differentiate the time factors of sounds. It is probably connected with the diminished function of inhibitory neurons.

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Age-related changes in GAD levels in the central auditory system of the rat

Cited by 112 publications

References 85 publications

Impaired Auditory Temporal Selectivity in the Inferior Colliculus of Aged Mongolian Gerbils

Impaired Auditory Temporal Selectivity in the Inferior Colliculus of Aged Mongolian Gerbils

Peripheral and central auditory assessment in among the elderly

Influence of age on speech intelligibility in babble noise

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