Age-Related Changes in Renal Connective Tissue of Rats

Distribution of Acid Mucopolysaccharides in Rat Kidneys and Effect of Unilateral Nephrectomy

“…In a previous work [3], in which whole kidney acid MPs were determined in various age groups of rats, it was found that the concentrations increased up to the 8th month of age. In the group consisting of 12-month-old rats the acid MP concentration was lower in comparison with the previous group (8 months old) while in the older groups thereafter il remained relatively constant.…”

“…It should be noted in addition that other authors also have reported data showing that the rat kidneys are relatively rich in heparin like material [13], while dog kidneys appear to contain more hyaluronic acid [7], Possible roles of renal hyaluronic acid [11] and of heparin like substances [3] have been suggested. But whatever the signifi cance of the qualitative nature of the renal MPs it may be sug gested that the tendency for increase of acid MPs in the cortex of the kidney under increased functional demand may reflect a physiological importance of these substances.…”

Levels of Acid M ucopolysaccharides in Aging Human Kidneys

“…He observed the parallel change between medullary connective tissue and renal arteriolosclerosis with ad vancing age and suggested the possible role of cortical arterioles for the 'biomorphosis' of the renal medulla. Recently, Ber et al [10] analyzed the whole kidney AMPS and hydroxyproline of rats belonging to various age groups. The concentration of AMPS was found to increase with age up to the 8th month and decrease slightly thereafter.…”