2005
DOI: 10.1093/intimm/dxh314
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Age-related differences in phenotype and function of CD4+ T cells are due to a phenotypic shift from naive to memory effector CD4+ T cells

Abstract: Based on the combined expression of CD27 and CD28, a putative model of T cell differentiation has been previously proposed. We used CD27 and CD28 expression in order to comparatively study the size, cytokine production capacity and proliferative response of CD4+ T cell sub-populations from healthy young and elderly volunteers. Elderly persons had a lower percentage of CD27+CD28+ but a higher percentage of CD27-CD28+ and CD27-CD28-CD4+ T cells than the young persons. CD27-CD28-CD4+ T cells were present, althoug… Show more

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Cited by 66 publications
(51 citation statements)
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“…Similarly, a decrease in gamma‐delta T cells has been reported previously 24, 25. Although CD27 expression was variable in the clusters detected by SWIFT, clusters 913, 1,328, and 908 were memory CD4 T cells that expressed low levels of CD27 and were over‐represented in the elderly, consistent with previous studies 26, 27, 28. Thus the competitive template assignment in SWIFT identified many potentially different clusters between young and elderly.…”
Section: Resultssupporting
confidence: 88%
“…Similarly, a decrease in gamma‐delta T cells has been reported previously 24, 25. Although CD27 expression was variable in the clusters detected by SWIFT, clusters 913, 1,328, and 908 were memory CD4 T cells that expressed low levels of CD27 and were over‐represented in the elderly, consistent with previous studies 26, 27, 28. Thus the competitive template assignment in SWIFT identified many potentially different clusters between young and elderly.…”
Section: Resultssupporting
confidence: 88%
“…39 Kovaiou at al. 40 studied CD4 subsets in healthy young and elderly volunteers finding increased CD27CCD28C T-cells (na€ ıve and early-differentiated cells) in younger people, while elderly presented more frequently CD27-CD28-T-cells (fully differentiated cells) demonstrating that the aging process was linked to a shift of CD4 T-cells from na€ ıve and early-differentiated to late differentiated subset. To better differentiate these phenotypes, the authors measured the presence of cell-surface markers, in particular CD45RA, receptors involved in lymphocyte homing [CCR7] and intercellular adhesion and co-stimulation [CD11a] associated with the different cellular subset ability to produce perforin.…”
Section: Immunology Of Aging In Hiv-infected Patientsmentioning
confidence: 98%
“…Finally the analysis of telomere length revealed a significantly shorter length in CD27-CD28-CD4C cells when compared with CD27CCD28CCD4C T-cells. 40 While CD4C na€ ıve T-cells decrease with age, memory CD4C T-cells expand thanks to the continuous antigen presentation and to homeostatic proliferation. [40][41][42] T lymphocytes with specificity for a particular pathogen can persist in the host for many years after the pathogen has been eliminated.…”
Section: Immunology Of Aging In Hiv-infected Patientsmentioning
confidence: 99%
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