Age-related differences in the neural correlates of trial-to-trial variations of reaction time

Adleman, Nancy E.; Chen, Gang; Reynolds, Richard C.; Frackman, Anna; Razdan, Varun; Weissman, Daniel H.; Pine, Daniel S.; Leibenluft, Ellen

doi:10.1016/j.dcn.2016.05.001

Cited by 24 publications

(36 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The final sample included 83 participants: 27 healthy volunteers, 31 individuals with DMDD, and 25 individuals with ADHD. Note that data from these 27 healthy volunteers have been examined previously as part of larger samples to examine age-related differences in the relationship between RT and activity on this task 32 and to examine potential neural endophenotypes of bipolar disorder. 25 Data from youth with DMDD and ADHD are novel and have not been examined previously.…”

Section: Methodsmentioning

confidence: 99%

“…22,32 Figure S1, available online, displays the four task stimuli that appeared with equal frequency. Each stimulus was a large letter made up of smaller letters (“H” or “S”).…”

Section: Methodsmentioning

confidence: 99%

“…Thus, trials were modeled with a 16.25s (13 TRs) window starting 2.5s before stimulus onset to examine pre-stimulus effects as in prior work. 22,25,32 Third-order Legendre polynomials modeling baseline drift and six head motion parameters were included to control for potential confounding effects.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Behavioral and Neural Sustained Attention Deficits in Disruptive Mood Dysregulation Disorder and Attention-Deficit/Hyperactivity Disorder

Pagliaccio

Wiggins

Adleman

et al. 2017

Journal of the American Academy of Child & Adolescent Psych

Self Cite

View full text Add to dashboard Cite

Objective Disruptive mood dysregulation disorder (DMDD), characterized by severe irritability, and attention-deficit/hyperactivity disorder (ADHD) are highly comorbid. This is the first study to characterize neural and behavioral similarities and differences in attentional functioning across these disorders. Method Twenty-seven healthy volunteers, 31 patients with DMDD, and 25 patients with ADHD (8–18-year-olds) completed a functional magnetic resonance imaging (fMRI) attention task. Group differences in intra-subject variability in reaction time (ISVRT) were examined. The current fMRI analytic approach precisely quantified trial-wise associations between reaction time and brain activity. Results Group differences manifested in the relationship between reaction time and brain activity (all regions: p<.01, F>2.54, ηp2>0.06). Patients with DMDD showed specific alterations in the right paracentral lobule, superior parietal lobule, fusiform gyrus, and cerebellar culmen. In contrast, both patients with DMDD and ADHD exhibited blunted compensatory increases in activity on long reaction time trials. Additionally, youth with DMDD exhibited increased activity in the postcentral gyrus, medial frontal gyrus, and cerebellar tonsil and declive (all regions: p<.05, F>2.46, ηp2>0.06). The groups in the imaging sample did not differ significantly in ISVRT (F[2,79]=2.664, p=.076, ηp2=0.063), though ISVRT was significantly elevated among youth with DMDD and ADHD when including those not meeting strict motion and accuracy criteria for the imaging analysis (F[2,96]=4.283, p=.017, ηp2=0.083). Conclusion Patients with DMDD exhibited specific alterations in the relationship between pre-stimulus brain activity and reaction time. Both patients with DMDD and ADHD exhibited similar blunting of compensatory neural activity in frontal, parietal, and other regions. Additionally, patients with DMDD demonstrated elevated reaction time variability relative to healthy youth. This work is the first to identify common and unique behavioral and neural signatures of DMDD and ADHD.

show abstract

Section: Methodsmentioning

confidence: 99%

“…22,32 Figure S1, available online, displays the four task stimuli that appeared with equal frequency. Each stimulus was a large letter made up of smaller letters (“H” or “S”).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Behavioral and Neural Sustained Attention Deficits in Disruptive Mood Dysregulation Disorder and Attention-Deficit/Hyperactivity Disorder

Pagliaccio

Wiggins

Adleman

et al. 2017

Journal of the American Academy of Child & Adolescent Psych

Self Cite

View full text Add to dashboard Cite

show abstract

“…Age-related effects have been identified previously in healthy individuals with this paradigm (32). However, age was not a significant covariate predicting RT-BOLD in any region that showed group differences, and all results held in an age-restricted sample.…”

Section: Discussionmentioning

confidence: 56%

“…Specifically, Weissman et al (2006) note trial-by-trial associations between attentional lapses and 1) pre-stimulus dips in anterior cingulate cortex (ACC), inferior frontal gyrus (IFG), and MFG activity; 2) increased compensatory activity in frontal, parietal, and subcortical regions; and 3) less task-related deactivation of default mode network regions. This trial-by-trial method also has been used successfully to associate weakened RT-BOLD associations with weakened attention control in sleep deprivation and (30, 31) and in youth vs. adults (32). The current study builds on this uniquely powerful research strategy to examine BP.…”

Section: Introductionmentioning

confidence: 99%

Behavioral and Neural Sustained Attention Deficits in Bipolar Disorder and Familial Risk of Bipolar Disorder

Pagliaccio

Wiggins

Adleman

et al. 2017

Biological Psychiatry

Self Cite

View full text Add to dashboard Cite

Background Few neuroimaging studies compare individuals affected with bipolar disorder (BP), at high familial risk for BP, and at low risk to identify endophenotypes for BP. None have examined variability in attention, despite promising behavioral work in this area. We used functional magnetic resonance imaging (fMRI) methods uniquely powered to compare the neural correlates of attention variability in these three groups. Methods The current study examined 106 8–25-year-olds who completed an fMRI attention task: 24 with BP, 29 at-risk based on a first-degree relative with BP, and 53 healthy, low-risk individuals. Group differences in intra-subject variability in reaction time were examined and a sophisticated fMRI analytic approach was used to quantify precisely trial-wise associations between reaction time and brain activity. The latter has not been examined previously in BP or risk for BP. Results Relative to healthy individuals, those with BP or at-risk for BP exhibited increased reaction time variability (F(2,102)=4.26, p=.02, ηp2=0.08). Importantly, we identified blunted relationships between trial-wise variation in reaction time and brain activity in the inferior and middle frontal gyri, precuneus, cingulate cortex, caudate, and postcentral gyrus (all regions: p<.001, ηp2>0.06) in both at-risk and BP individuals compared to healthy, low-risk individuals. This blunting partially mediated group differences in reaction time variability (β=0.010, 95% Confidence Interval=[0.002–0.020], Sobel Z=2.08, p=.038). Conclusions Blunting in key frontal, cingulate, and striatal areas was evident in unaffected, at-risk individuals and in euthymic BP patients. Elucidating such novel neural endophenotypes can facilitate new approaches to BP prediction, diagnosis, and prevention.

show abstract

Aggressive behaviors predict greater intraindividual reaction time variability in children: Evidence from cross‐lagged panel models

Zhang,

Wang

2023

Aggressive Behavior

View full text Add to dashboard Cite

Deficits in attentional control or inhibitory control are distinct features of childhood aggressive behaviors. Lower attentional control or inhibitory control is considered to predict more aggressive behaviors, while few studies have documented the possible predictive effects of aggressive behaviors on attentional control or inhibitory control. The present study examined the bidirectional relations between aggressive behaviors and both inhibitory control and attentional control in 169 Chinese primary school children (75 girls, Mage = 7.15, SDage = 0.33), annually for 3 years starting at age 7. The No‐go accuracy on a Go/No‐go task was used as the index of inhibitory control, and the intraindividual reaction time variability (IIRTV) of correct Go trials indicated attentional control. The aggressive behaviors subscale of the child behavior checklist–Chinese version was used to assess the children's aggressive behaviors. The results demonstrated a significant and stable predictive effect of previous aggressive behaviors on subsequent attentional control, with more aggressive behaviors predicting greater IIRTV at both the between‐child and within‐child levels. No significant effects of inhibitory control or attentional control on aggressive behaviors or sex‐specific patterns were found. The findings suggest the negative impact of childhood aggressive behaviors on attentional control and underscore the importance of early prevention and intervention for childhood aggressive behaviors.

show abstract

Age-related differences in the neural correlates of trial-to-trial variations of reaction time

Cited by 24 publications

References 66 publications

Behavioral and Neural Sustained Attention Deficits in Disruptive Mood Dysregulation Disorder and Attention-Deficit/Hyperactivity Disorder

Behavioral and Neural Sustained Attention Deficits in Disruptive Mood Dysregulation Disorder and Attention-Deficit/Hyperactivity Disorder

Behavioral and Neural Sustained Attention Deficits in Bipolar Disorder and Familial Risk of Bipolar Disorder

Aggressive behaviors predict greater intraindividual reaction time variability in children: Evidence from cross‐lagged panel models

Contact Info

Product

Resources

About