Age-related medication adherence in patients with chronic heart failure: A systematic literature review

Krueger, Katrin; Botermann, Lea; Schorr, Susanne Gabriele; Griese‐Mammen, Nina; Laufs, Ulrich; Schulz, Martin

doi:10.1016/j.ijcard.2015.03.042

Cited by 72 publications

(55 citation statements)

References 73 publications

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“…New evidence suggests that older age is not related to poorer medication adherence to cardiovascular medication. A recent systematic search of the bibliographic database MEDLINE and all Cochrane databases, analysing the relationship between age and medication adherence in adult patients with chronic heart failure (CHF), showed that older age alone is not related to poorer medication adherence compared with younger patients with CHF 41. Our study does not support this concern.…”

Section: Discussioncontrasting

confidence: 86%

Therapy discontinuation or substitution in patients with cardiovascular disease, switching among different products of the same off-patent active substance: a ‘real-world’ retrospective cohort study

Esposti¹,

Sangiorgi²,

Buda³

et al. 2016

BMJ Open

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ObjectiveThe present study investigated the effects of switching to different products of the same off-patent active substance (brand name or generic) on therapy discontinuation or substitution with another molecule of the same class, in patients with cardiovascular disease treated with statins and antihypertensives in a ‘real-world’ setting.DesignA retrospective cohort study in a ‘real-world’ setting.SettingAnalysis of data performed by integrating administrative databases that included approximately two million individuals who are assisted by the National Health System from three Local Health Units located in three different regions of Italy.ParticipantsAll patients aged ≥18 years with at least one prescription of simvastatin, ramipril or amlodipine in the period 1 January to 31 December 2010 were included and followed up for 2 years.Main outcome measuresPrescription refills occurring during follow-up were evaluated. Frequency of discontinuation of therapy or substitution with another molecule of the same class (eg, from simvastatin to a different statin) during follow-up was identified.ResultsDuring follow-up, therapy discontinuation or substitution was found to be more frequent in patients switching to a different product of the same active substance compared with non-switching patients (11.5% vs 10.8% and 22.2% vs 20.8% (p=0.002), respectively, in the simvastatin group; 4.0% vs 3.5% and 24.6% vs 22.7% (p<0.001), respectively, in the amlodipine group). In the ramipril group, 8% of patients undertook a therapy substitution to another molecule; no trend towards a lower percentage of substitution was observed in the non-switching group, while 18% of patients discontinued treatment, with a significant difference in favour of patients not switching. These findings were partially confirmed by multivariate analysis.ConclusionsSwitches among products of the same active substance are quite common in patients with cardiovascular disease. Our study suggests that switching may expose patients to a higher risk of therapy discontinuation or substitution.

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Section: Discussioncontrasting

confidence: 86%

Therapy discontinuation or substitution in patients with cardiovascular disease, switching among different products of the same off-patent active substance: a ‘real-world’ retrospective cohort study

Esposti¹,

Sangiorgi²,

Buda³

et al. 2016

BMJ Open

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“…The age of a patient is a factor that determines the consistency of adherence to medical recommendations (Hinkin et al, 2004;Michetti et al, 2016;Krueger et al, 2015). This explains why attempts have been made to identify the factors that influence the level of patient disobedience in three age groups.…”

Section: Discussionmentioning

confidence: 99%

“…Despite some difficulty in identification of such a set of factors, age is definitely a variable to be taken into account (Krueger et al, 2015;Krivoy et al, 2015). Additionally, it seems that factors which impact patient behaviour can vary depending on the age of an individual, although little research has been devoted to this issue (Barclay et al, 2007).…”

Section: Methodsmentioning

confidence: 99%

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Factors Impacting On Patient Compliance with Medical Advice: Empirical Study

Krot

Sousa²

2017

Engineering Management in Production and Services

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The purpose of this paper to identify factors which have a bearing on compliance with medical advice in various age groups. The survey was conducted, using the CAWI method, on a representative sample of 1000 respondents who declared having used healthcare services in the previous six months. Control of competences is one of the strongest factors which is common for the oldest and youngest groups. Interestingly, trust in the integrity and honesty of doctors is significant for the youngest patients, i.e., the higher is the level of trust, the lower is the tendency to non-comply. Another type of trust is related to the benevolence of doctors and is significant to patients of the middle age group. Satisfaction is a significant predictor in the two oldest groups of patients. High levels of satisfaction seem to deter people from non-adherence to recommended treatment regimens. The results of the present study provide knowledge about the nature and diversity of factors behind patient compliance in various age groups.

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“…Despite the presence of numerous data on the socio-demographic and clinical factors affecting the degree of patients' adherence to prescribed therapeutic measures (e.g., the impact of the disease severity [8,9], the dosing regimen [10], patients' sex and age [11][12][13], as well as their social status and education level [14]), the question of the influence of patients' personality on their therapeutic behaviour, and the question of influence of certain psychological characteristics on patients' degree of adherence, remain open.…”

Section: Introductionmentioning

confidence: 99%

Adherence to treatment after CABG in terms of patients’ personality

et al. 2018

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Abstract. The relevance of the problem is caused by the prevalence of cardiovascular diseases among the population, including coronary heart disease which requires surgical treatment, on the one hand, and low rates of treatment adherence among patients with chronic diseases, which reduce the effectiveness of the treatment and survival rates of patients, on the other hand. Patients after CABG were divided into groups according to the degree of their adherence to treatment and were examined by using the Big Five Questionnaire. Differences between the groups on the scales "conscientiousness" (p < 0.001), "openness" (p < 0.001), "agreeableness" (p < 0.05), and "neuroticism" (p < 0.05) were revealed. The study showed that the psychological factors are relevant in the definition of adherence to treatment and patients' personality traits are potentially significant for the prediction of its degree among patients after CABG.

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Age-related medication adherence in patients with chronic heart failure: A systematic literature review

Cited by 72 publications

References 73 publications

Therapy discontinuation or substitution in patients with cardiovascular disease, switching among different products of the same off-patent active substance: a ‘real-world’ retrospective cohort study

Therapy discontinuation or substitution in patients with cardiovascular disease, switching among different products of the same off-patent active substance: a ‘real-world’ retrospective cohort study

Factors Impacting On Patient Compliance with Medical Advice: Empirical Study

Adherence to treatment after CABG in terms of patients’ personality

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