Age threshold for proper definition of premature coronary artery disease in males

Abder-Rahman, Hasan A.; Al-Abdallat, Imad M.; Idhair, Ahmed K.F.

doi:10.1016/j.jflm.2018.04.011

Cited by 19 publications

(15 citation statements)

References 16 publications

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“…When CAD occurs in younger than expected patients it is considered to be premature CAD. However, the definition of premature CAD is difficult because of the variation in risk factors in different populations [4]. Chinese studies use the definition of men with onset age < 55 years, and women with onset age < 65 years [5].…”

Section: Introductionmentioning

confidence: 99%

Coronary plaque tissue characterization in patients with premature coronary artery disease

Xie

Mao

et al. 2020

Int J Cardiovasc Imaging

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Premature coronary artery disease (CAD) studies rarely involve coronary plaque characterization. We characterize coronary plaque tissue by radiofrequency intravascular ultrasound (IVUS) in patients with premature CAD. From July 2015 to December 2017, 220 patients from the Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine with first occurrence of angina or myocardial infarction within 3 months were enrolled. Patients with premature CAD (n = 47, males aged < 55 years, and females aged < 65 years) or later CAD (n = 155) were retrospectively compared for cardiovascular risk factors, laboratory examination findings, coronary angiography data, gray-scale IVUS, and iMap-IVUS. The mean age was 53.53 ± 7.24 vs. 70.48 ± 8.74 years (p < 0.001). The groups were similar for traditional coronary risk factors except homocysteine (18.60 ± 5.15 vs. 17.08 ± 4.27 µmol/L, p = 0.043). After matching for baseline characteristics, LDL cholesterol (LDL-C) was higher for premature CAD than later CAD (2.50 ± 0.96 vs. 2.17 ± 0.80 mmol/L, p = 0.019). Before the matching procedure, the premature CAD group had shorter target lesion length [18.50 (12.60-32.00) vs. 27.90 (18.70-37.40) mm, p = 0.002], less plaque volume [175.59 (96.60-240.50) vs. 214.73 (139.74-330.00) mm 3 , p = 0.013] than the later CAD group. After the matching procedure, the premature CAD group appeared to be less plaque burden (72.69 ± 9.99 vs. 74.85 ± 9.80%, p = 0.005), and positive remodeling (1.03 ± 0.12 vs. 0.94 ± 0.18, p = 0.034), and lower high risk feature incidence (p = 0.006) than the later CAD group. At the plaque's minimum lumen, premature CAD had more fibrotic (p < 0.001), less necrotic (p = 0.001) and less calcified areas (p = 0.012). Coronary plaque tissue was more fibrotic with less necrotic and calcified components in premature than in later CAD, and the range and degree of atherosclerosis were significantly lower.

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Section: Introductionmentioning

confidence: 99%

Coronary plaque tissue characterization in patients with premature coronary artery disease

Xie

Mao

et al. 2020

Int J Cardiovasc Imaging

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“…In a review study on autopsy reports, 49-54 period was reported as "turn-interval," and ages under 49 were deemed PCAD in males. Nonetheless, most studies still use 45 and 55 as the threshold for PCAD in males and females, respectively [30,31]. High prevalence and considerable morbidity and mortality highlight the importance of developing e cient screening methods for the early diagnosis of PCAD.…”

Section: Discussionmentioning

confidence: 99%

Association Between Serum Gamma-Glutamyl Transferase and Alkaline Phosphatase with Presence of Premature Coronary Artery Disease: Findings from Khuzestan Comprehensive Health Study (KCHS)

Khaboushan,

Masoudkabir,

Jalali

et al. 2023

Preprint

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Background Coronary artery disease has remained the leading cause of death worldwide. Premature coronary artery disease (PCAD) is defined as the incidence of coronary artery disease in males ≤ 45 and females ≤ 55. This study aimed to investigate the association between the concentrations of gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) with the presence of PCAD for the first time in a large general population in a developing country. Methods A total of 20,542 from the Khuzestan Comprehensive Health Study participants were entered into the study based on the inclusion and exclusion criteria. The association of the GGT and ALP levels with the presence of PCAD was analyzed with multiple logistic regression models adjusted for gender, dyslipidemia, triglyceride concentration, cigarette smoking, opium consumption, hypertension, diabetes mellitus, and age. Moreover, the receiver operating characteristic (ROC) was used to assess the predictive power of GGT and ALP for PCAD. Results While in univariate analyses both ALP and GGT were significantly associated with the presence of PCAD [GGT: odds ratio (OR), 1.008; 95% confidence interval (CI), 1.005–1.011; p-value < 0.0001; ALP: OR, 1.003; CI, 1.002–1.004; p-value < 0.0001], after adjusting for confounders, the associations were no longer significant (GGT p-value = 0.177; ALP p-value = 0.963). However, the addition of the GGT to the conventional cardiovascular risk factors improved the predictive value of the model for the presence of PCAD in females (p-value < 0.05). Conclusions In conclusion, although ALP showed no independent association with PCAD, adding GGT to conventional cardiovascular risk factors could significantly improve the prediction of PCAD in female participants.

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“…Our acceptance of the definition of premature MI as age < 55 years, could be a matter of debate. As there is no consensus for a universally accepted age cut-off for defining young MI, there is a disparity in the literature; some studies vary from < 40 to < 55 years of age and others define young MI as <45 years of age [ 18 , 19 , 20 , 21 , 22 ]. We accepted the Framingham cohort’s cut off which has defined premature MI as < 55 years of age which is also the adopted definition of premature MI for men and women by CV disease management algorithms established by the Ministry of Health in our country [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of the COVID-19 pandemic in patients with a previous history of premature myocardial infarction

Kayıkçıoğlu

Tunçel

Tokgözoğlu

2020

American Journal of Preventive Cardiology

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Age threshold for proper definition of premature coronary artery disease in males

Cited by 19 publications

References 16 publications

Coronary plaque tissue characterization in patients with premature coronary artery disease

Coronary plaque tissue characterization in patients with premature coronary artery disease

Association Between Serum Gamma-Glutamyl Transferase and Alkaline Phosphatase with Presence of Premature Coronary Artery Disease: Findings from Khuzestan Comprehensive Health Study (KCHS)

Impact of the COVID-19 pandemic in patients with a previous history of premature myocardial infarction

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