Aged-Related Changes in Learning and Memory, Choline Acetyltransferase Activity and Number of Neuronal Cells in Rats.

Ishimaru, Hirohisa; Ogawa, Shin-ichi; Fuji, Kazuyuki; Fukuta, Takanori; Kameyama, Tsutomu; Nabeshima, Toshitaka

doi:10.1248/bpb1978.14.321

Cited by 23 publications

(9 citation statements)

References 12 publications

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“…Computerassisted analyses of NADPH-d histochemistry revealed that the number of relatively large NADPH-d-positive neurons was decreased, while the number of small neurons was largely unaffected in aged rats compared to that in young rats (Yamada et al, 1996c). In agreement with the our results, many studies have reported that the number of cortical neurons remains stable during the aging process, in both humans and rodents (Hornberger et al, 1985;Ishimaru et al, 1991;Nemni et al, 1992;Terry et al, 1987). Accordingly, ours findings indicate that the reduction in the number of NADPH-d-positive cells in the cerebral cortex appears to be relatively selective in aged rats (Noda et al, 1997;Yamada et al, 1996c).…”

Section: Changes In Nos-containingsupporting

confidence: 91%

“…For instance, aged rats show impairments of spatial reference memory (Gage et al, 1984;Ishimaru et al, 1991;Nabeshima et al, 1993b;Yamada et al, 1996c) and working memory (Frick et al, 1995;Miyagawa et al, 1998), as well as altered emotional behavior (Hasegawa et al, 1996;Miyagawa et al, 1998;Nabeshima et al, 1993a). Accordingly, it is plausible that learning and memory impairment and altered emotion in aged rats may be associated with the decline of NO production in the brain (Noda et al, 1997;Yamada et al, 1996c).…”

Section: Functional Significance Of Changesmentioning

confidence: 99%

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Changes in NMDA receptor/ nitric oxide signaling pathway in the brain with aging

Yamada

Nabeshima

1998

Microsc. Res. Tech.

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Section: Changes In Nos-containingsupporting

confidence: 91%

Section: Functional Significance Of Changesmentioning

confidence: 99%

Changes in NMDA receptor/ nitric oxide signaling pathway in the brain with aging

Yamada

Nabeshima

1998

Microsc. Res. Tech.

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“…Previous reports have varied, showing that ChAT activity was re duced with age in a number of brain regions [29] or in few brain regions [30,31]. We believe that these differences in results are due to differences in the animal strains used, to differences in the environment in which the rats were reared or to the season of supply.…”

Section: Discussionmentioning

confidence: 80%

Oral Administration of NGF Synthesis Stimulators Recovers Reduced Brain NGF Content in Aged Rats and Cognitive Dysfunction in Basal – Forebrain – Lesioned Rats

et al. 1994

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Nerve growth factor (NGF) plays an important role in the survival and maintenance of cholinergic neurons in the central neuronal system. Since this factor does not cross the blood-brain barrier and is easily metabolized by peptidases when administered peripherally, it can be used for medical treatment only when directly injected into the brain. We report here that repeated oral administration of the stimulators for the NGF synthesis, idebenone and propentofylline, produced a significant recovery of the reduced NGF content in the frontal and parietal cortices of aged rats. These compounds also improved deficits of performance in water maze, passive avoidance and habituation tasks in basal-forebrain-lesioned rats. These results suggest that the use of the stimulators for the NGF synthesis may provide a therapeutic approach to cholinergic dysfunction.

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“…We found that the activity of CHAT, a marker enzyme in cholinergic neurons, did not change with age. Previous reports have shown that ChAT activity is reduced with age in a number or few regions of the brain (Ishimaru et al, 1991;Luine and Hearns, 1990;Nabeshima et al, 1993;. These discrepancies are considered to be due to differences in the animal strains used, or in the environment in which the rats were reared.…”

Section: Discussionmentioning

confidence: 99%

Difference in toxicity of β-amyloid peptide with aging in relation to nerve growth factor content in rat brain

et al. 2001

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Amyloid beta-peptide (Abeta) is the major constituent of the senile plaques in the brains of patients with Alzheimer's disease. We have demonstrated previously that memory impairment, dysfunction of the cholinergic and dopaminergic neuronal system and morphological degeneration are produced after the continuous infusion of Abeta into the cerebral ventricle in 8-week-old rat. In the present study, we investigated the toxicity of Abeta in infant (10 days old), adult (8 weeks old) and aged (20 months old) rats in relation to nerve growth factor (NGF) content in various regions of the brain. After a 2-week-infusion, choline acetyltransferase (ChAT) activity was significantly decreased in the hippocampus of adult, but not infant or aged rats. NGF levels in the hippocampus were increased only in adult rats. These results suggest that Abeta is toxic only in the matured adult brain, and that the mechanism of toxicity is related to NGF synthesis.

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Aged-Related Changes in Learning and Memory, Choline Acetyltransferase Activity and Number of Neuronal Cells in Rats.

Cited by 23 publications

References 12 publications

Changes in NMDA receptor/ nitric oxide signaling pathway in the brain with aging

Changes in NMDA receptor/ nitric oxide signaling pathway in the brain with aging

Oral Administration of NGF Synthesis Stimulators Recovers Reduced Brain NGF Content in Aged Rats and Cognitive Dysfunction in Basal – Forebrain – Lesioned Rats

Difference in toxicity of β-amyloid peptide with aging in relation to nerve growth factor content in rat brain

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