Ageing and mesenchymal stem cells derived exosomes: Molecular insight and challenges

Ahmadi, Mahdi; Rezaie, Jafar

doi:10.1002/cbf.3602

Cited by 73 publications

(55 citation statements)

References 83 publications

(97 reference statements)

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“…Rezaie et al reported MSCs and their exosomes kinetic are affected by aging and other aged exosomes. Exosomes from aged MSCs lose their regeneration potential, accelerating biological development and negatively impacting the function of recipient cells ( 69 ). Choosing an appropriate pathway for exosomes to access target sites is another issue that needs to be addressed.…”

Section: Discussionmentioning

confidence: 99%

A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021

Guan

Song

et al. 2021

Front. Cardiovasc. Med.

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Background: Exosomes in cardiovascular diseases (CVDs) have become an active research field with substantial value and potential. Nevertheless, there are few bibliometric studies in this field. We aimed to visualize the research hotspots and trends of exosomes in CVDs using a bibliometric analysis to help understand the future development of basic and clinical research.Methods: The articles and reviews regarding exosomes in the CVDs were culled from the Web of Science Core Collection, and knowledge maps were generated using CiteSpace and VOSviewer software.Results: A total of 1,039 articles were included. The number of exosome articles in the CVDs increased yearly. These publications came from 60 countries/regions, led by the US and China. The primary research institutions were Shanghai Jiao Tong University and Nanjing Medical University. Circulation Research was the journal and co-cited journal with the most studies. We identified 473 authors among which Lucio Barile had the most significant number of articles and Thery C was co-cited most often. After analysis, the most common keywords are myocardium infarction, microRNA and mesenchymal stem cells. Ischemic heart disease, pathogenesis, regeneration, stem cells, targeted therapy, biomarkers, cardiac protection, and others are current and developing areas of study.Conclusion: We identified the research hotspots and trends of exosomes in CVDs using bibliometric and visual methods. Research on exosomes is flourishing in the cardiovascular medicine. Regenerative medicine, exosome engineering, delivery vehicles, and biomarkers will likely become the focus of future research.

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Section: Discussionmentioning

confidence: 99%

A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021

Guan

Song

et al. 2021

Front. Cardiovasc. Med.

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“…Due to MSCs lack the expression of membrane bound molecules involved in immune rejection which enable their allogenic transplantation, the clinical applications of MSCbased therapy have witnessed an outstanding achievement (Ahmadi and Rezaie, 2021). Nevertheless, in the long-term follow up, safety issues regarding MSCs-based therapy are still a matter of debate.…”

Section: Evs-based Covid-19 Therapy Msc and Msc-evsmentioning

confidence: 99%

The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge

Yan

Zhou

Wang

et al. 2021

Front. Mol. Biosci.

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SARS-CoV-2 infection has become an urgent public health concern worldwide, severely affecting our society and economy due to the long incubation time and high prevalence. People spare no effort on the rapid development of vaccine and treatment all over the world. Amongst the numerous ways of tackling this pandemic, some approaches using extracellular vesicles (EVs) are emerging. In this review, we summarize current prevalence and pathogenesis of COVID-19, involving the combination of SARS-CoV-2 and virus receptor ACE2, endothelial dysfunction and micro thrombosis, together with cytokine storm. We also discuss the ongoing EVs-based strategies for the treatment of COVID-19, including mesenchymal stem cell (MSC)-EVs, drug-EVs, vaccine-EVs, platelet-EVs, and others. This manuscript provides the foundation for the development of targeted drugs and vaccines for SARS-CoV-2 infections.

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“…Exosomes serve as a new therapeutic target and could act as a biomarker for various disorders including cardiac disease ( 190 ). Mesenchymal stem cell derived exosomes (MSC-exo) used for various aging related diseases ( 192 ).…”

Section: Stem Cellsmentioning

confidence: 99%

Stem Cell-Derived Exosomes Potential Therapeutic Roles in Cardiovascular Diseases

Jayaraman

Gnanasampanthapandian

Rajasingh

et al. 2021

Front. Cardiovasc. Med.

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Owing to myocardial abnormalities, cardiac ailments are considered to be the major cause of morbidity and mortality worldwide. According to a recent study, membranous vesicles that are produced naturally, termed as “exosomes”, have emerged as the potential candidate in the field of cardiac regenerative medicine. A wide spectrum of stem cells has also been investigated in the treatment of cardiovascular diseases (CVD). Exosomes obtained from the stem cells are found to be cardioprotective and offer great hope in the treatment of CVD. The basic nature of exosomes is to deal with the intracellular delivery of both proteins and nucleic acids. This activity of exosomes helps us to rely on them as the attractive pharmaceutical delivery agents. Most importantly, exosomes derived from microRNAs (miRNAs) hold great promise in assessing the risk of CVD, as they serve as notable biomarkers of the disease. Exosomes are small, less immunogenic, and lack toxicity. These nanovesicles harbor immense potential as a therapeutic entity and would provide fruitful benefits if consequential research were focused on their upbringing and development as a useful diagnostic and therapeutic tool in the field of medicine.

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Ageing and mesenchymal stem cells derived exosomes: Molecular insight and challenges

Cited by 73 publications

References 83 publications

A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021

A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021

The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge

Stem Cell-Derived Exosomes Potential Therapeutic Roles in Cardiovascular Diseases

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